Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflamm...

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Autores principales:	Claudia M. Wunderlich, P. Justus Ackermann, Anna Lena Ostermann, Petra Adams-Quack, Merly C. Vogt, My-Ly Tran, Alexei Nikolajev, Ari Waisman, Christoph Garbers, Sebastian Theurich, Jan Mauer, Nadine Hövelmeyer, F. Thomas Wunderlich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8aa769939cda447285b994dfedfa8895
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spelling	oai:doaj.org-article:8aa769939cda447285b994dfedfa88952021-12-02T16:49:35ZObesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment10.1038/s41467-018-03773-02041-1723https://doaj.org/article/8aa769939cda447285b994dfedfa88952018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03773-0https://doaj.org/toc/2041-1723Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflammation and CAC progression.Claudia M. WunderlichP. Justus AckermannAnna Lena OstermannPetra Adams-QuackMerly C. VogtMy-Ly TranAlexei NikolajevAri WaismanChristoph GarbersSebastian TheurichJan MauerNadine HövelmeyerF. Thomas WunderlichNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudia M. Wunderlich P. Justus Ackermann Anna Lena Ostermann Petra Adams-Quack Merly C. Vogt My-Ly Tran Alexei Nikolajev Ari Waisman Christoph Garbers Sebastian Theurich Jan Mauer Nadine Hövelmeyer F. Thomas Wunderlich Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
description	Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflammation and CAC progression.
format	article
author	Claudia M. Wunderlich P. Justus Ackermann Anna Lena Ostermann Petra Adams-Quack Merly C. Vogt My-Ly Tran Alexei Nikolajev Ari Waisman Christoph Garbers Sebastian Theurich Jan Mauer Nadine Hövelmeyer F. Thomas Wunderlich
author_facet	Claudia M. Wunderlich P. Justus Ackermann Anna Lena Ostermann Petra Adams-Quack Merly C. Vogt My-Ly Tran Alexei Nikolajev Ari Waisman Christoph Garbers Sebastian Theurich Jan Mauer Nadine Hövelmeyer F. Thomas Wunderlich
author_sort	Claudia M. Wunderlich
title	Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_short	Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_full	Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_fullStr	Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_full_unstemmed	Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_sort	obesity exacerbates colitis-associated cancer via il-6-regulated macrophage polarisation and ccl-20/ccr-6-mediated lymphocyte recruitment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8aa769939cda447285b994dfedfa8895
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Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

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