A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations
Introduction Many experimental and clinical trials have suggested that flaxseed might be a potent antihypertensive, but the evidence concerning the effects of flaxseed supplements on plasma C-reactive protein (CRP) concentrations has not been fully conclusive. We assessed the impact of the effects o...
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2018
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oai:doaj.org-article:8aafe19bdc8340d082914ecfde579cfd2021-12-02T18:33:21ZA systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations1734-19221896-915110.5114/aoms.2018.81034https://doaj.org/article/8aafe19bdc8340d082914ecfde579cfd2018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/A-systematic-review-and-meta-analysis-of-clinical-trials-investigating-the-effects,74141,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Many experimental and clinical trials have suggested that flaxseed might be a potent antihypertensive, but the evidence concerning the effects of flaxseed supplements on plasma C-reactive protein (CRP) concentrations has not been fully conclusive. We assessed the impact of the effects of flaxseed supplementation on plasma CRP concentrations through a systematic review of literature and meta-analysis of available randomised controlled trials (RCTs). Material and methods The literature search included EMBASE, ProQuest, CINAHL, and PUBMED databases up to 1st February 2016 to identify RCTs investigating the effect of flaxseed supplements on plasma CRP concentrations. Meta-analysis was performed using a random-effects model, and effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI). Results Meta-analysis of 17 selected RCTs with 1256 individuals did not suggest a significant change in plasma CRP concentrations following supplementation with flaxseed-containing products (WMD: –0.25 mg/l, 95% CI: –0.53, 0.02, p = 0.074). The effect size was robust in the leave-one-out sensitivity analysis. Subgroup analysis did not suggest any significant difference in terms of changing plasma CRP concentrations among different types of flaxseed supplements used in the included studies, i.e. flaxseed oil (WMD: –0.67 mg/l, 95% CI: –2.00, 0.65, p = 0.320), lignan extract (WMD: –0.32 mg/l, 95% CI: –0.71, 0.06, p = 0.103) and ground powder (WMD: –0.18 mg/l, 95% CI: –0.42, 0.06, p = 0.142). Conclusions The meta-analysis of RCTs did not show a significant change in plasma CRP concentrations following supplementation with various flaxseed products. Large, well-designed studies should be still performed to validate the current results.Sorin UrsoniuAmirhossein SahebkarMaria-Corina SerbanIulia PinzaruCristina DeheleanLavinia NoveanuJacek RyszMaciej BanachLipid and Blood Pressure Meta-analysis Collaboration (LBPMC) GroupTermedia Publishing Housearticleflaxseedlinseedlinum usitatissimumc-reactive proteinmeta-analysissystematic reviewMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 12-22 (2018) |
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EN |
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flaxseed linseed linum usitatissimum c-reactive protein meta-analysis systematic review Medicine R |
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flaxseed linseed linum usitatissimum c-reactive protein meta-analysis systematic review Medicine R Sorin Ursoniu Amirhossein Sahebkar Maria-Corina Serban Iulia Pinzaru Cristina Dehelean Lavinia Noveanu Jacek Rysz Maciej Banach Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations |
| description |
Introduction
Many experimental and clinical trials have suggested that flaxseed might be a potent antihypertensive, but the evidence concerning the effects of flaxseed supplements on plasma C-reactive protein (CRP) concentrations has not been fully conclusive. We assessed the impact of the effects of flaxseed supplementation on plasma CRP concentrations through a systematic review of literature and meta-analysis of available randomised controlled trials (RCTs).
Material and methods
The literature search included EMBASE, ProQuest, CINAHL, and PUBMED databases up to 1st February 2016 to identify RCTs investigating the effect of flaxseed supplements on plasma CRP concentrations. Meta-analysis was performed using a random-effects model, and effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI).
Results
Meta-analysis of 17 selected RCTs with 1256 individuals did not suggest a significant change in plasma CRP concentrations following supplementation with flaxseed-containing products (WMD: –0.25 mg/l, 95% CI: –0.53, 0.02, p = 0.074). The effect size was robust in the leave-one-out sensitivity analysis. Subgroup analysis did not suggest any significant difference in terms of changing plasma CRP concentrations among different types of flaxseed supplements used in the included studies, i.e. flaxseed oil (WMD: –0.67 mg/l, 95% CI: –2.00, 0.65, p = 0.320), lignan extract (WMD: –0.32 mg/l, 95% CI: –0.71, 0.06, p = 0.103) and ground powder (WMD: –0.18 mg/l, 95% CI: –0.42, 0.06, p = 0.142).
Conclusions
The meta-analysis of RCTs did not show a significant change in plasma CRP concentrations following supplementation with various flaxseed products. Large, well-designed studies should be still performed to validate the current results. |
| format |
article |
| author |
Sorin Ursoniu Amirhossein Sahebkar Maria-Corina Serban Iulia Pinzaru Cristina Dehelean Lavinia Noveanu Jacek Rysz Maciej Banach Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group |
| author_facet |
Sorin Ursoniu Amirhossein Sahebkar Maria-Corina Serban Iulia Pinzaru Cristina Dehelean Lavinia Noveanu Jacek Rysz Maciej Banach Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group |
| author_sort |
Sorin Ursoniu |
| title |
A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations |
| title_short |
A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations |
| title_full |
A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations |
| title_fullStr |
A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations |
| title_full_unstemmed |
A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations |
| title_sort |
systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma c-reactive protein concentrations |
| publisher |
Termedia Publishing House |
| publishDate |
2018 |
| url |
https://doaj.org/article/8aafe19bdc8340d082914ecfde579cfd |
| work_keys_str_mv |
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