Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts

Abstract Background Theobroma cacao Linn. husks are considered agricultural wastes, but studies show that they exhibit natural compounds that may be used in alternative medicine. Hence, this study was conducted to determine the antidiabetic, anti-inflammatory, and cytotoxic potential of T. cacao hus...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julius Kevin Cura, Antonio Basilio, Ma. Cristina De Las Llagas
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Diabetes Inflammation Cytotoxicity Theobroma cacao Linn. Husks Alternative medicine Medicine R Homeopathy RX1-681
Acceso en línea:	https://doaj.org/article/8ab0130d89ce4f75a348b36c3dc89633
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8ab0130d89ce4f75a348b36c3dc89633
record_format	dspace
spelling	oai:doaj.org-article:8ab0130d89ce4f75a348b36c3dc896332021-12-05T12:17:37ZAntidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts10.1186/s40816-021-00320-12199-1197https://doaj.org/article/8ab0130d89ce4f75a348b36c3dc896332021-12-01T00:00:00Zhttps://doi.org/10.1186/s40816-021-00320-1https://doaj.org/toc/2199-1197Abstract Background Theobroma cacao Linn. husks are considered agricultural wastes, but studies show that they exhibit natural compounds that may be used in alternative medicine. Hence, this study was conducted to determine the antidiabetic, anti-inflammatory, and cytotoxic potential of T. cacao husk aqueous extracts (TCE). Results A significantly higher glucose dialysis retardation index (GDRI) was shown by 10% TCE than the rest of the concentrations (1%, 3%, 5%, 7%) (P<0.05), and its activity is comparable with 5% Metformin (positive control) after 30 min, 60 min, 120 min and 180 min of incubation. The 7% TCE also showed significantly higher GDRI than the 5%, 3%, and 1% concentrations (P<0.05), and its activity is comparable with 5% Metformin after 60 min and 180 min of incubation. Moreover, 10% TCE exhibited a significantly higher glucose uptake percentage than the rest of the samples (P<0.05) and has activity comparable with 5% Metformin. The anti-inflammatory assay showed a significantly higher inhibition rate of 10% TCE than the rest of the concentrations (P<0.05), and its activity is comparable with 5% Diclofenac (positive control). The cytotoxicity assay showed that the percentage mortality of brine shrimps after 24 h of exposure to the different TCE samples is less than 50%. Conclusion This study concludes that T. cacao husk aqueous extract has potential antidiabetic and anti-inflammatory properties without being toxic to cells.Julius Kevin CuraAntonio BasilioMa. Cristina De Las LlagasSpringerOpenarticleDiabetesInflammationCytotoxicityTheobroma cacao Linn. HusksAlternative medicineMedicineRHomeopathyRX1-681ENClinical Phytoscience, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetes Inflammation Cytotoxicity Theobroma cacao Linn. Husks Alternative medicine Medicine R Homeopathy RX1-681
spellingShingle	Diabetes Inflammation Cytotoxicity Theobroma cacao Linn. Husks Alternative medicine Medicine R Homeopathy RX1-681 Julius Kevin Cura Antonio Basilio Ma. Cristina De Las Llagas Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts
description	Abstract Background Theobroma cacao Linn. husks are considered agricultural wastes, but studies show that they exhibit natural compounds that may be used in alternative medicine. Hence, this study was conducted to determine the antidiabetic, anti-inflammatory, and cytotoxic potential of T. cacao husk aqueous extracts (TCE). Results A significantly higher glucose dialysis retardation index (GDRI) was shown by 10% TCE than the rest of the concentrations (1%, 3%, 5%, 7%) (P<0.05), and its activity is comparable with 5% Metformin (positive control) after 30 min, 60 min, 120 min and 180 min of incubation. The 7% TCE also showed significantly higher GDRI than the 5%, 3%, and 1% concentrations (P<0.05), and its activity is comparable with 5% Metformin after 60 min and 180 min of incubation. Moreover, 10% TCE exhibited a significantly higher glucose uptake percentage than the rest of the samples (P<0.05) and has activity comparable with 5% Metformin. The anti-inflammatory assay showed a significantly higher inhibition rate of 10% TCE than the rest of the concentrations (P<0.05), and its activity is comparable with 5% Diclofenac (positive control). The cytotoxicity assay showed that the percentage mortality of brine shrimps after 24 h of exposure to the different TCE samples is less than 50%. Conclusion This study concludes that T. cacao husk aqueous extract has potential antidiabetic and anti-inflammatory properties without being toxic to cells.
format	article
author	Julius Kevin Cura Antonio Basilio Ma. Cristina De Las Llagas
author_facet	Julius Kevin Cura Antonio Basilio Ma. Cristina De Las Llagas
author_sort	Julius Kevin Cura
title	Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts
title_short	Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts
title_full	Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts
title_fullStr	Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts
title_full_unstemmed	Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts
title_sort	antidiabetic, anti-inflammatory and cytotoxic potential of theobroma cacao linn. husk aqueous extracts
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/8ab0130d89ce4f75a348b36c3dc89633
work_keys_str_mv	AT juliuskevincura antidiabeticantiinflammatoryandcytotoxicpotentialoftheobromacacaolinnhuskaqueousextracts AT antoniobasilio antidiabeticantiinflammatoryandcytotoxicpotentialoftheobromacacaolinnhuskaqueousextracts AT macristinadelasllagas antidiabeticantiinflammatoryandcytotoxicpotentialoftheobromacacaolinnhuskaqueousextracts
_version_	1718372086263578624

Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts

Ejemplares similares