The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients

Introduction: Accumulating evidence had demonstrated that females had a higher risk of deep vein thrombosis (DVT) than males, but the mechanism was still unknown. Vitamin D was found to play an essential role in DVT, and gender may influence the serum vitamin D levels. This study aimed to explore wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiejie Tao, Feiling Lou, Yuntao Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	stroke deep venous thrombosis gender vitamin D seniors Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/8ab339da989043e49f065506a91cebb6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8ab339da989043e49f065506a91cebb6
record_format	dspace
spelling	oai:doaj.org-article:8ab339da989043e49f065506a91cebb62021-12-02T10:14:21ZThe Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients2296-861X10.3389/fnut.2021.755883https://doaj.org/article/8ab339da989043e49f065506a91cebb62021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.755883/fullhttps://doaj.org/toc/2296-861XIntroduction: Accumulating evidence had demonstrated that females had a higher risk of deep vein thrombosis (DVT) than males, but the mechanism was still unknown. Vitamin D was found to play an essential role in DVT, and gender may influence the serum vitamin D levels. This study aimed to explore whether vitamin D played a role in the gender difference in DVT.Materials and Methods: A total of 444 patients with acute stroke were recruited, which were divided into the DVT group (n = 222) and the non-DVT group (n = 222). Serum vitamin D levels were measured after admission and were split into three categories, including deficiency (<50 nmol/L), insufficiency (52.5–72.5 nmol/L), and sufficiency (more than 75 nmol/L). Hierarchical regression analysis was adopted to analyze the relationship between gender and DVT, controlling the confounding factors.Results: Females showed a higher proportion of DVT than males (60.7 vs. 42.5%, p < 0.001), and lower serum vitamin D levels than males (53.44 ± 16.45 vs. 69.43 ± 23.14, p < 0.001). Moreover, serum vitamin D levels were lower in the DVT group than in the non-DVT group (59.44 ± 19.61 vs. 66.24 ± 23.86, p < 0.001). Besides, the DVT group showed a lower proportion of vitamin D sufficiency than the non-DVT group (21.2 vs. 32.9%, p < 0.05). Hierarchical regression analysis showed that females had 2.083-fold (p < 0.001, unadjusted model) and 1.413-fold (p = 0.155, adjusted model) risk to develop DVT. In addition, the sufficiency status of vitamin D showed an independent protective effect on DVT (unadjusted model OR, 0.504, p = 0.004; adjusted model OR, 0.686, p = 0.011).Conclusion: Females had a higher risk of DVT than males, and vitamin D may play an essential role in this relationship. Further studies are needed to explore whether vitamin D supplementation could reduce DVT risk in stroke patients, especially females.Jiejie TaoFeiling LouYuntao LiuFrontiers Media S.A.articlestrokedeep venous thrombosisgendervitamin DseniorsNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke deep venous thrombosis gender vitamin D seniors Nutrition. Foods and food supply TX341-641
spellingShingle	stroke deep venous thrombosis gender vitamin D seniors Nutrition. Foods and food supply TX341-641 Jiejie Tao Feiling Lou Yuntao Liu The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients
description	Introduction: Accumulating evidence had demonstrated that females had a higher risk of deep vein thrombosis (DVT) than males, but the mechanism was still unknown. Vitamin D was found to play an essential role in DVT, and gender may influence the serum vitamin D levels. This study aimed to explore whether vitamin D played a role in the gender difference in DVT.Materials and Methods: A total of 444 patients with acute stroke were recruited, which were divided into the DVT group (n = 222) and the non-DVT group (n = 222). Serum vitamin D levels were measured after admission and were split into three categories, including deficiency (<50 nmol/L), insufficiency (52.5–72.5 nmol/L), and sufficiency (more than 75 nmol/L). Hierarchical regression analysis was adopted to analyze the relationship between gender and DVT, controlling the confounding factors.Results: Females showed a higher proportion of DVT than males (60.7 vs. 42.5%, p < 0.001), and lower serum vitamin D levels than males (53.44 ± 16.45 vs. 69.43 ± 23.14, p < 0.001). Moreover, serum vitamin D levels were lower in the DVT group than in the non-DVT group (59.44 ± 19.61 vs. 66.24 ± 23.86, p < 0.001). Besides, the DVT group showed a lower proportion of vitamin D sufficiency than the non-DVT group (21.2 vs. 32.9%, p < 0.05). Hierarchical regression analysis showed that females had 2.083-fold (p < 0.001, unadjusted model) and 1.413-fold (p = 0.155, adjusted model) risk to develop DVT. In addition, the sufficiency status of vitamin D showed an independent protective effect on DVT (unadjusted model OR, 0.504, p = 0.004; adjusted model OR, 0.686, p = 0.011).Conclusion: Females had a higher risk of DVT than males, and vitamin D may play an essential role in this relationship. Further studies are needed to explore whether vitamin D supplementation could reduce DVT risk in stroke patients, especially females.
format	article
author	Jiejie Tao Feiling Lou Yuntao Liu
author_facet	Jiejie Tao Feiling Lou Yuntao Liu
author_sort	Jiejie Tao
title	The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients
title_short	The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients
title_full	The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients
title_fullStr	The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients
title_full_unstemmed	The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients
title_sort	role of vitamin d in the relationship between gender and deep vein thrombosis among stroke patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8ab339da989043e49f065506a91cebb6
work_keys_str_mv	AT jiejietao theroleofvitamindintherelationshipbetweengenderanddeepveinthrombosisamongstrokepatients AT feilinglou theroleofvitamindintherelationshipbetweengenderanddeepveinthrombosisamongstrokepatients AT yuntaoliu theroleofvitamindintherelationshipbetweengenderanddeepveinthrombosisamongstrokepatients AT jiejietao roleofvitamindintherelationshipbetweengenderanddeepveinthrombosisamongstrokepatients AT feilinglou roleofvitamindintherelationshipbetweengenderanddeepveinthrombosisamongstrokepatients AT yuntaoliu roleofvitamindintherelationshipbetweengenderanddeepveinthrombosisamongstrokepatients
_version_	1718397464971575296

The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients

Ejemplares similares