Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia

Xuan Liu,1,2 Junjian Zhang,1 Dong Sun,1 Yuanteng Fan,1 Hongbin Zhou,2 Binfang Fu21Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 2Department of Neurology, Xiangyang Central Hospital, Medical College, Hubei University of Arts and Science, Xiangyang, Hubei, People’s Rep...

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Autores principales:	Liu X, Zhang JJ, Sun D, Fan YT, Zhou HB, Fu BF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Brain-derived neurotrophic factor cognition fluoxetine improvement neuroplasticity vascular dementia. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/8ab50e58b20c4fa5ba3c3bde8a267f53
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spelling	oai:doaj.org-article:8ab50e58b20c4fa5ba3c3bde8a267f532021-12-02T10:10:12ZEffects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia1178-1998https://doaj.org/article/8ab50e58b20c4fa5ba3c3bde8a267f532014-03-01T00:00:00Zhttps://www.dovepress.com/effects-of-fluoxetine-on-brain-derived-neurotrophic-factor-serum-conce-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xuan Liu,1,2 Junjian Zhang,1 Dong Sun,1 Yuanteng Fan,1 Hongbin Zhou,2 Binfang Fu21Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 2Department of Neurology, Xiangyang Central Hospital, Medical College, Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of ChinaBackground: Selective serotonin reuptake inhibitors improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of selective serotonin reuptake inhibitors on cognition and serum BDNF levels in patients with vascular dementia are largely unknown. We performed an open-label study to investigate the effects of fluoxetine, a selective serotonin reuptake inhibitor, on cognition and serum BDNF levels in patients with vascular dementia.Methods: Fifty patients with vascular dementia were randomly allocated to receive fluoxetine (20 mg/day; n=25) or no fluoxetine (control group; n=25) for 12 weeks. Both groups received secondary prevention of stroke. Serum BDNF level, Mini-Mental State Examination (MMSE) score, Ten-Point Clock Drawing score, and Digit Span Test and Verbal Fluency Test scores were measured at baseline and at week 12 in the both groups.Results: The baseline serum BDNF level correlated significantly with the MMSE score. MMSE score, Ten-Point Clock Drawing score, and serum BDNF level increased significantly in the fluoxetine group but not in the control group. The increase in serum BDNF level correlated with the increase in MMSE score in the fluoxetine group.Conclusion: Fluoxetine may potentially improve cognition in patients with vascular dementia and requires further investigation. BDNF may play an important role in cognitive recovery.Keywords: brain-derived neurotrophic factor, cognition, fluoxetine, improvement, neuroplasticity, vascular dementiaLiu XZhang JJSun DFan YTZhou HBFu BFDove Medical PressarticleBrain-derived neurotrophic factorcognitionfluoxetineimprovementneuroplasticityvascular dementia.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 411-419 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brain-derived neurotrophic factor cognition fluoxetine improvement neuroplasticity vascular dementia. Geriatrics RC952-954.6
spellingShingle	Brain-derived neurotrophic factor cognition fluoxetine improvement neuroplasticity vascular dementia. Geriatrics RC952-954.6 Liu X Zhang JJ Sun D Fan YT Zhou HB Fu BF Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia
description	Xuan Liu,1,2 Junjian Zhang,1 Dong Sun,1 Yuanteng Fan,1 Hongbin Zhou,2 Binfang Fu21Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 2Department of Neurology, Xiangyang Central Hospital, Medical College, Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of ChinaBackground: Selective serotonin reuptake inhibitors improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of selective serotonin reuptake inhibitors on cognition and serum BDNF levels in patients with vascular dementia are largely unknown. We performed an open-label study to investigate the effects of fluoxetine, a selective serotonin reuptake inhibitor, on cognition and serum BDNF levels in patients with vascular dementia.Methods: Fifty patients with vascular dementia were randomly allocated to receive fluoxetine (20 mg/day; n=25) or no fluoxetine (control group; n=25) for 12 weeks. Both groups received secondary prevention of stroke. Serum BDNF level, Mini-Mental State Examination (MMSE) score, Ten-Point Clock Drawing score, and Digit Span Test and Verbal Fluency Test scores were measured at baseline and at week 12 in the both groups.Results: The baseline serum BDNF level correlated significantly with the MMSE score. MMSE score, Ten-Point Clock Drawing score, and serum BDNF level increased significantly in the fluoxetine group but not in the control group. The increase in serum BDNF level correlated with the increase in MMSE score in the fluoxetine group.Conclusion: Fluoxetine may potentially improve cognition in patients with vascular dementia and requires further investigation. BDNF may play an important role in cognitive recovery.Keywords: brain-derived neurotrophic factor, cognition, fluoxetine, improvement, neuroplasticity, vascular dementia
format	article
author	Liu X Zhang JJ Sun D Fan YT Zhou HB Fu BF
author_facet	Liu X Zhang JJ Sun D Fan YT Zhou HB Fu BF
author_sort	Liu X
title	Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia
title_short	Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia
title_full	Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia
title_fullStr	Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia
title_full_unstemmed	Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia
title_sort	effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/8ab50e58b20c4fa5ba3c3bde8a267f53
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Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia

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