Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease
Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible bi...
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2020
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oai:doaj.org-article:8ab912eda75443699d2e15309d47801d2021-12-02T14:40:40ZAnalysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease10.1038/s41467-020-15065-72041-1723https://doaj.org/article/8ab912eda75443699d2e15309d47801d2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15065-7https://doaj.org/toc/2041-1723Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible biological target.Costanza L. VallergaFutao ZhangJaved FowdarAllan F. McRaeTing QiMarta F. NabaisQian ZhangIrfahan KassamAnjali K. HendersLeanne WallaceGrant MontgomeryYu-Hsuan ChuangSteve HorvathBeate RitzGlenda HallidayIan HickieJohn B. KwokJohn PearsonToni PitcherMartin KennedySteven R. BentleyPeter A. SilburnJian YangNaomi R. WraySimon J. G. LewisTim AndersonJohn Dalrymple-AlfordGeorge D. MellickPeter M. VisscherJacob GrattenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
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Science Q Costanza L. Vallerga Futao Zhang Javed Fowdar Allan F. McRae Ting Qi Marta F. Nabais Qian Zhang Irfahan Kassam Anjali K. Henders Leanne Wallace Grant Montgomery Yu-Hsuan Chuang Steve Horvath Beate Ritz Glenda Halliday Ian Hickie John B. Kwok John Pearson Toni Pitcher Martin Kennedy Steven R. Bentley Peter A. Silburn Jian Yang Naomi R. Wray Simon J. G. Lewis Tim Anderson John Dalrymple-Alford George D. Mellick Peter M. Visscher Jacob Gratten Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| description |
Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible biological target. |
| format |
article |
| author |
Costanza L. Vallerga Futao Zhang Javed Fowdar Allan F. McRae Ting Qi Marta F. Nabais Qian Zhang Irfahan Kassam Anjali K. Henders Leanne Wallace Grant Montgomery Yu-Hsuan Chuang Steve Horvath Beate Ritz Glenda Halliday Ian Hickie John B. Kwok John Pearson Toni Pitcher Martin Kennedy Steven R. Bentley Peter A. Silburn Jian Yang Naomi R. Wray Simon J. G. Lewis Tim Anderson John Dalrymple-Alford George D. Mellick Peter M. Visscher Jacob Gratten |
| author_facet |
Costanza L. Vallerga Futao Zhang Javed Fowdar Allan F. McRae Ting Qi Marta F. Nabais Qian Zhang Irfahan Kassam Anjali K. Henders Leanne Wallace Grant Montgomery Yu-Hsuan Chuang Steve Horvath Beate Ritz Glenda Halliday Ian Hickie John B. Kwok John Pearson Toni Pitcher Martin Kennedy Steven R. Bentley Peter A. Silburn Jian Yang Naomi R. Wray Simon J. G. Lewis Tim Anderson John Dalrymple-Alford George D. Mellick Peter M. Visscher Jacob Gratten |
| author_sort |
Costanza L. Vallerga |
| title |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_short |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_full |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_fullStr |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_full_unstemmed |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_sort |
analysis of dna methylation associates the cystine–glutamate antiporter slc7a11 with risk of parkinson’s disease |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8ab912eda75443699d2e15309d47801d |
| work_keys_str_mv |
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