Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer

Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer

Abstract We studied the incidence of HPV genotypes in mostly Black women with cervical carcinoma and correlated histopathologic tumor characteristics, immune markers and clinical data with survival. Disease-free survival (DFS) and overall survival (OS) were recorded for 60 months post-diagnosis. Fif...

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Autores principales: Rachelle P. Mendoza, Tahmineh Haidary, Elmer Gabutan, Ying Yin Zhou, Zaheer Bukhari, Courtney Connelly, Wen-Ching Lee, Yi-Chun Lee, Raj Wadgaonkar, Raag Agrawal, M. A. Haseeb, Raavi Gupta
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/8ab96b152efb45fb933267759e17be5a
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spelling oai:doaj.org-article:8ab96b152efb45fb933267759e17be5a2021-12-02T15:39:59ZMixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer10.1038/s41598-021-93485-12045-2322https://doaj.org/article/8ab96b152efb45fb933267759e17be5a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93485-1https://doaj.org/toc/2045-2322Abstract We studied the incidence of HPV genotypes in mostly Black women with cervical carcinoma and correlated histopathologic tumor characteristics, immune markers and clinical data with survival. Disease-free survival (DFS) and overall survival (OS) were recorded for 60 months post-diagnosis. Fifty four of the 60 (90%) patients were Black and 36 (60%) were < 55 years of age. Of the 40 patients with typeable HPV genotypes, 10 (25%) had 16/18 HPV genotypes, 30 (75%) had one of the non-16/18 HPV genotypes, and 20 (50%) had one of the 7 genotypes (35, 39, 51, 53, 56, 59 and 68) that are not included in the nonavalent vaccine. Mixed HPV infections (≥ 2 types) were found in 11/40 (27.5%) patients. Patients infected with non-16/18 genotypes, including the most common genotype, HPV 35, had significantly shorter DFS and OS. PD-L1 (p = 0.003), MMR expression (p = 0.01), clinical stage (p = 0.048), histologic grade (p = 0.015) and mixed HPV infection (p = 0.026) were independent predictors of DFS. A remarkably high proportion of cervical cancer cells in our patients expressed PD-L1 which opens the possibility of the use of immune checkpoint inhibitors to treat these cancers. Exclusion of the common HPV genotypes from the vaccine exacerbates mortality from cervical cancer in underserved Black patients.Rachelle P. MendozaTahmineh HaidaryElmer GabutanYing Yin ZhouZaheer BukhariCourtney ConnellyWen-Ching LeeYi-Chun LeeRaj WadgaonkarRaag AgrawalM. A. HaseebRaavi GuptaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Rachelle P. Mendoza
Tahmineh Haidary
Elmer Gabutan
Ying Yin Zhou
Zaheer Bukhari
Courtney Connelly
Wen-Ching Lee
Yi-Chun Lee
Raj Wadgaonkar
Raag Agrawal
M. A. Haseeb
Raavi Gupta
Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
description Abstract We studied the incidence of HPV genotypes in mostly Black women with cervical carcinoma and correlated histopathologic tumor characteristics, immune markers and clinical data with survival. Disease-free survival (DFS) and overall survival (OS) were recorded for 60 months post-diagnosis. Fifty four of the 60 (90%) patients were Black and 36 (60%) were < 55 years of age. Of the 40 patients with typeable HPV genotypes, 10 (25%) had 16/18 HPV genotypes, 30 (75%) had one of the non-16/18 HPV genotypes, and 20 (50%) had one of the 7 genotypes (35, 39, 51, 53, 56, 59 and 68) that are not included in the nonavalent vaccine. Mixed HPV infections (≥ 2 types) were found in 11/40 (27.5%) patients. Patients infected with non-16/18 genotypes, including the most common genotype, HPV 35, had significantly shorter DFS and OS. PD-L1 (p = 0.003), MMR expression (p = 0.01), clinical stage (p = 0.048), histologic grade (p = 0.015) and mixed HPV infection (p = 0.026) were independent predictors of DFS. A remarkably high proportion of cervical cancer cells in our patients expressed PD-L1 which opens the possibility of the use of immune checkpoint inhibitors to treat these cancers. Exclusion of the common HPV genotypes from the vaccine exacerbates mortality from cervical cancer in underserved Black patients.
format article
author Rachelle P. Mendoza
Tahmineh Haidary
Elmer Gabutan
Ying Yin Zhou
Zaheer Bukhari
Courtney Connelly
Wen-Ching Lee
Yi-Chun Lee
Raj Wadgaonkar
Raag Agrawal
M. A. Haseeb
Raavi Gupta
author_facet Rachelle P. Mendoza
Tahmineh Haidary
Elmer Gabutan
Ying Yin Zhou
Zaheer Bukhari
Courtney Connelly
Wen-Ching Lee
Yi-Chun Lee
Raj Wadgaonkar
Raag Agrawal
M. A. Haseeb
Raavi Gupta
author_sort Rachelle P. Mendoza
title Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
title_short Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
title_full Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
title_fullStr Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
title_full_unstemmed Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
title_sort mixed and nonvaccine high risk hpv types are associated with higher mortality in black women with cervical cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/8ab96b152efb45fb933267759e17be5a
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