Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction

Abstract The aim of the present study is to systematically evaluate the impact of RDN on cardiac structure and function in patients with resistant hypertension (RH) or diastolic dysfunction. We retrieved Pubmed, Embase and Cocharane Library databases, from inception to April 1st, 2016. Studies repor...

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Autores principales:	Shiying Wang, Suxia Yang, Xinxin Zhao, Jun Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8abb375ab6dc49ceaffd07f6048cae98
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spelling	oai:doaj.org-article:8abb375ab6dc49ceaffd07f6048cae982021-12-02T15:07:47ZEffects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction10.1038/s41598-017-18671-62045-2322https://doaj.org/article/8abb375ab6dc49ceaffd07f6048cae982018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-18671-6https://doaj.org/toc/2045-2322Abstract The aim of the present study is to systematically evaluate the impact of RDN on cardiac structure and function in patients with resistant hypertension (RH) or diastolic dysfunction. We retrieved Pubmed, Embase and Cocharane Library databases, from inception to April 1st, 2016. Studies reporting left ventricular mass (LVMI) or left ventricular (LV) diastolic function (reflected by the ratio of mitral inflow velocity to annular relaxation velocity [E/e’]) responses to RDN were included. Two randomized controlled trials (RCTs), 3 controlled studies and 11 uncontrolled studies were finally identified. In observational studies, there was a reduction in LVMI, E/e’ and N-terminal pro B-type natriuretic peptide (BNP) at 6 months, compared with pre-RDN values. LV ejection fraction (LVEF) elevated at 6 months following RDN. In RCTs, however, no significant change in LVMI, E/e’, BNP, left atrial volume index or LVEF was observed at 12 months, compared with pharmaceutical therapy. In summary, both LV hypertrophy and cardiac function improved at 6 months after RDN. Nonetheless, current evidence failed to show that RDN was superior to intensive (optimal) drug therapy in improving cardiac remodeling and function.Shiying WangSuxia YangXinxin ZhaoJun ShiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shiying Wang Suxia Yang Xinxin Zhao Jun Shi Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction
description	Abstract The aim of the present study is to systematically evaluate the impact of RDN on cardiac structure and function in patients with resistant hypertension (RH) or diastolic dysfunction. We retrieved Pubmed, Embase and Cocharane Library databases, from inception to April 1st, 2016. Studies reporting left ventricular mass (LVMI) or left ventricular (LV) diastolic function (reflected by the ratio of mitral inflow velocity to annular relaxation velocity [E/e’]) responses to RDN were included. Two randomized controlled trials (RCTs), 3 controlled studies and 11 uncontrolled studies were finally identified. In observational studies, there was a reduction in LVMI, E/e’ and N-terminal pro B-type natriuretic peptide (BNP) at 6 months, compared with pre-RDN values. LV ejection fraction (LVEF) elevated at 6 months following RDN. In RCTs, however, no significant change in LVMI, E/e’, BNP, left atrial volume index or LVEF was observed at 12 months, compared with pharmaceutical therapy. In summary, both LV hypertrophy and cardiac function improved at 6 months after RDN. Nonetheless, current evidence failed to show that RDN was superior to intensive (optimal) drug therapy in improving cardiac remodeling and function.
format	article
author	Shiying Wang Suxia Yang Xinxin Zhao Jun Shi
author_facet	Shiying Wang Suxia Yang Xinxin Zhao Jun Shi
author_sort	Shiying Wang
title	Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction
title_short	Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction
title_full	Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction
title_fullStr	Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction
title_full_unstemmed	Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction
title_sort	effects of renal denervation on cardiac structural and functional abnormalities in patients with resistant hypertension or diastolic dysfunction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8abb375ab6dc49ceaffd07f6048cae98
work_keys_str_mv	AT shiyingwang effectsofrenaldenervationoncardiacstructuralandfunctionalabnormalitiesinpatientswithresistanthypertensionordiastolicdysfunction AT suxiayang effectsofrenaldenervationoncardiacstructuralandfunctionalabnormalitiesinpatientswithresistanthypertensionordiastolicdysfunction AT xinxinzhao effectsofrenaldenervationoncardiacstructuralandfunctionalabnormalitiesinpatientswithresistanthypertensionordiastolicdysfunction AT junshi effectsofrenaldenervationoncardiacstructuralandfunctionalabnormalitiesinpatientswithresistanthypertensionordiastolicdysfunction
_version_	1718388401452875776

Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction

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