A scalable fabrication process of polymer microneedles

Sixing Yang, Yan Feng, Lijun Zhang, Nixiang Chen, Weien Yuan, Tuo JinSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, People&#39;s Republic of ChinaAbstract: While polymer microneedles may easily be fabricated by casting a solution in a mold, either centrifugation or vacuumizing...

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Autores principales:	Yang S, Feng Y, Zhang L, Chen N, Yuan W, Jin T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8abb528e1485465488a985f3e81e25d8
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spelling	oai:doaj.org-article:8abb528e1485465488a985f3e81e25d82021-12-02T02:49:07ZA scalable fabrication process of polymer microneedles1176-91141178-2013https://doaj.org/article/8abb528e1485465488a985f3e81e25d82012-03-01T00:00:00Zhttp://www.dovepress.com/a-scalable-fabrication-process-of-polymer-microneedles-a9454https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sixing Yang, Yan Feng, Lijun Zhang, Nixiang Chen, Weien Yuan, Tuo JinSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, People&#39;s Republic of ChinaAbstract: While polymer microneedles may easily be fabricated by casting a solution in a mold, either centrifugation or vacuumizing is needed to pull the viscous polymer solution into the microholes of the mold. We report a novel process to fabricate polymer microneedles with a one-sided vacuum using a ceramic mold that is breathable but water impermeable. A polymer solution containing polyvinyl alcohol and polysaccharide was cast in a ceramic mold and then pulled into the microholes by a vacuum applied to the opposite side of the mold. After cross-linking and solidification through freeze-thawing, the microneedle patch was detached from the mold and transferred with a specially designed instrument for the drying process, during which the patch shrank evenly to form an array of regular and uniform needles without deformation. Moreover, the shrinkage of the patches helped to reduce the needles&#39; size to ease microfabrication of the male mold. The dried microneedle patches were finally punched to the desired sizes to achieve various properties, including sufficient strength to penetrate skin, microneedles-absorbed water-swelling ratios, and drug-release kinetics. The results showed that the microneedles were strong enough to penetrate pigskin and that their performance was satisfactory in terms of swelling and drug release.Keywords: polymer microneedles, ceramic mold, polyvinyl alcohol, swellingYang SFeng YZhang LChen NYuan WJin TDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1415-1422 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yang S Feng Y Zhang L Chen N Yuan W Jin T A scalable fabrication process of polymer microneedles
description	Sixing Yang, Yan Feng, Lijun Zhang, Nixiang Chen, Weien Yuan, Tuo JinSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, People&#39;s Republic of ChinaAbstract: While polymer microneedles may easily be fabricated by casting a solution in a mold, either centrifugation or vacuumizing is needed to pull the viscous polymer solution into the microholes of the mold. We report a novel process to fabricate polymer microneedles with a one-sided vacuum using a ceramic mold that is breathable but water impermeable. A polymer solution containing polyvinyl alcohol and polysaccharide was cast in a ceramic mold and then pulled into the microholes by a vacuum applied to the opposite side of the mold. After cross-linking and solidification through freeze-thawing, the microneedle patch was detached from the mold and transferred with a specially designed instrument for the drying process, during which the patch shrank evenly to form an array of regular and uniform needles without deformation. Moreover, the shrinkage of the patches helped to reduce the needles&#39; size to ease microfabrication of the male mold. The dried microneedle patches were finally punched to the desired sizes to achieve various properties, including sufficient strength to penetrate skin, microneedles-absorbed water-swelling ratios, and drug-release kinetics. The results showed that the microneedles were strong enough to penetrate pigskin and that their performance was satisfactory in terms of swelling and drug release.Keywords: polymer microneedles, ceramic mold, polyvinyl alcohol, swelling
format	article
author	Yang S Feng Y Zhang L Chen N Yuan W Jin T
author_facet	Yang S Feng Y Zhang L Chen N Yuan W Jin T
author_sort	Yang S
title	A scalable fabrication process of polymer microneedles
title_short	A scalable fabrication process of polymer microneedles
title_full	A scalable fabrication process of polymer microneedles
title_fullStr	A scalable fabrication process of polymer microneedles
title_full_unstemmed	A scalable fabrication process of polymer microneedles
title_sort	scalable fabrication process of polymer microneedles
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/8abb528e1485465488a985f3e81e25d8
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_version_	1718402112007700480

A scalable fabrication process of polymer microneedles

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