Expanding the binding specificity for RNA recognition by a PUF domain

The PUF RNAbinding domain has an eight-repeat structure with the ability to bind an eight-base RNA sequence. Here the authors generate a comprehensive library of variants of a PUF domain to find an RNA binding code and design PUF domains that recognize an arbitrary RNA sequence.

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Autores principales:	Wei Zhou, Daniel Melamed, Gabor Banyai, Cindy Meyer, Thomas Tuschl, Marvin Wickens, Junyue Cao, Stanley Fields
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8abbe09d95d44802b66fcda81e99f8ca
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spelling	oai:doaj.org-article:8abbe09d95d44802b66fcda81e99f8ca2021-12-02T15:09:09ZExpanding the binding specificity for RNA recognition by a PUF domain10.1038/s41467-021-25433-62041-1723https://doaj.org/article/8abbe09d95d44802b66fcda81e99f8ca2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25433-6https://doaj.org/toc/2041-1723The PUF RNAbinding domain has an eight-repeat structure with the ability to bind an eight-base RNA sequence. Here the authors generate a comprehensive library of variants of a PUF domain to find an RNA binding code and design PUF domains that recognize an arbitrary RNA sequence.Wei ZhouDaniel MelamedGabor BanyaiCindy MeyerThomas TuschlMarvin WickensJunyue CaoStanley FieldsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Zhou Daniel Melamed Gabor Banyai Cindy Meyer Thomas Tuschl Marvin Wickens Junyue Cao Stanley Fields Expanding the binding specificity for RNA recognition by a PUF domain
description	The PUF RNAbinding domain has an eight-repeat structure with the ability to bind an eight-base RNA sequence. Here the authors generate a comprehensive library of variants of a PUF domain to find an RNA binding code and design PUF domains that recognize an arbitrary RNA sequence.
format	article
author	Wei Zhou Daniel Melamed Gabor Banyai Cindy Meyer Thomas Tuschl Marvin Wickens Junyue Cao Stanley Fields
author_facet	Wei Zhou Daniel Melamed Gabor Banyai Cindy Meyer Thomas Tuschl Marvin Wickens Junyue Cao Stanley Fields
author_sort	Wei Zhou
title	Expanding the binding specificity for RNA recognition by a PUF domain
title_short	Expanding the binding specificity for RNA recognition by a PUF domain
title_full	Expanding the binding specificity for RNA recognition by a PUF domain
title_fullStr	Expanding the binding specificity for RNA recognition by a PUF domain
title_full_unstemmed	Expanding the binding specificity for RNA recognition by a PUF domain
title_sort	expanding the binding specificity for rna recognition by a puf domain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8abbe09d95d44802b66fcda81e99f8ca
work_keys_str_mv	AT weizhou expandingthebindingspecificityforrnarecognitionbyapufdomain AT danielmelamed expandingthebindingspecificityforrnarecognitionbyapufdomain AT gaborbanyai expandingthebindingspecificityforrnarecognitionbyapufdomain AT cindymeyer expandingthebindingspecificityforrnarecognitionbyapufdomain AT thomastuschl expandingthebindingspecificityforrnarecognitionbyapufdomain AT marvinwickens expandingthebindingspecificityforrnarecognitionbyapufdomain AT junyuecao expandingthebindingspecificityforrnarecognitionbyapufdomain AT stanleyfields expandingthebindingspecificityforrnarecognitionbyapufdomain
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Expanding the binding specificity for RNA recognition by a PUF domain

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