Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

The iron-sulfur cluster (ISC) assembly complex is activated by frataxin (FXN) and Friedreich’s ataxia is caused by FXN deficiency. Here the authors present the 3.2 Å resolution cryo-EM structure of the human frataxin bound ISC complex and discuss how FXN activates enzymatic activity.

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Autores principales:	Nicholas G. Fox, Xiaodi Yu, Xidong Feng, Henry J. Bailey, Alain Martelli, Joseph F. Nabhan, Claire Strain-Damerell, Christine Bulawa, Wyatt W. Yue, Seungil Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8abcf6459af9457bb7545657bbc6ed8d
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spelling	oai:doaj.org-article:8abcf6459af9457bb7545657bbc6ed8d2021-12-02T14:38:39ZStructure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism10.1038/s41467-019-09989-y2041-1723https://doaj.org/article/8abcf6459af9457bb7545657bbc6ed8d2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09989-yhttps://doaj.org/toc/2041-1723The iron-sulfur cluster (ISC) assembly complex is activated by frataxin (FXN) and Friedreich’s ataxia is caused by FXN deficiency. Here the authors present the 3.2 Å resolution cryo-EM structure of the human frataxin bound ISC complex and discuss how FXN activates enzymatic activity.Nicholas G. FoxXiaodi YuXidong FengHenry J. BaileyAlain MartelliJoseph F. NabhanClaire Strain-DamerellChristine BulawaWyatt W. YueSeungil HanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas G. Fox Xiaodi Yu Xidong Feng Henry J. Bailey Alain Martelli Joseph F. Nabhan Claire Strain-Damerell Christine Bulawa Wyatt W. Yue Seungil Han Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
description	The iron-sulfur cluster (ISC) assembly complex is activated by frataxin (FXN) and Friedreich’s ataxia is caused by FXN deficiency. Here the authors present the 3.2 Å resolution cryo-EM structure of the human frataxin bound ISC complex and discuss how FXN activates enzymatic activity.
format	article
author	Nicholas G. Fox Xiaodi Yu Xidong Feng Henry J. Bailey Alain Martelli Joseph F. Nabhan Claire Strain-Damerell Christine Bulawa Wyatt W. Yue Seungil Han
author_facet	Nicholas G. Fox Xiaodi Yu Xidong Feng Henry J. Bailey Alain Martelli Joseph F. Nabhan Claire Strain-Damerell Christine Bulawa Wyatt W. Yue Seungil Han
author_sort	Nicholas G. Fox
title	Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
title_short	Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
title_full	Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
title_fullStr	Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
title_full_unstemmed	Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
title_sort	structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8abcf6459af9457bb7545657bbc6ed8d
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Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

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