Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lip...

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Autores principales:	Vahid Kheirollahi, Roxana M. Wasnick, Valentina Biasin, Ana Ivonne Vazquez-Armendariz, Xuran Chu, Alena Moiseenko, Astrid Weiss, Jochen Wilhelm, Jin-San Zhang, Grazyna Kwapiszewska, Susanne Herold, Ralph T. Schermuly, Bernard Mari, Xiaokun Li, Werner Seeger, Andreas Günther, Saverio Bellusci, Elie El Agha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8abd0f7510244108a605662c2e07b3a9
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spelling	oai:doaj.org-article:8abd0f7510244108a605662c2e07b3a92021-12-02T16:57:21ZMetformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis10.1038/s41467-019-10839-02041-1723https://doaj.org/article/8abd0f7510244108a605662c2e07b3a92019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10839-0https://doaj.org/toc/2041-1723Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lipogenic transdifferentiation of myofibroblasts.Vahid KheirollahiRoxana M. WasnickValentina BiasinAna Ivonne Vazquez-ArmendarizXuran ChuAlena MoiseenkoAstrid WeissJochen WilhelmJin-San ZhangGrazyna KwapiszewskaSusanne HeroldRalph T. SchermulyBernard MariXiaokun LiWerner SeegerAndreas GüntherSaverio BellusciElie El AghaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vahid Kheirollahi Roxana M. Wasnick Valentina Biasin Ana Ivonne Vazquez-Armendariz Xuran Chu Alena Moiseenko Astrid Weiss Jochen Wilhelm Jin-San Zhang Grazyna Kwapiszewska Susanne Herold Ralph T. Schermuly Bernard Mari Xiaokun Li Werner Seeger Andreas Günther Saverio Bellusci Elie El Agha Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
description	Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lipogenic transdifferentiation of myofibroblasts.
format	article
author	Vahid Kheirollahi Roxana M. Wasnick Valentina Biasin Ana Ivonne Vazquez-Armendariz Xuran Chu Alena Moiseenko Astrid Weiss Jochen Wilhelm Jin-San Zhang Grazyna Kwapiszewska Susanne Herold Ralph T. Schermuly Bernard Mari Xiaokun Li Werner Seeger Andreas Günther Saverio Bellusci Elie El Agha
author_facet	Vahid Kheirollahi Roxana M. Wasnick Valentina Biasin Ana Ivonne Vazquez-Armendariz Xuran Chu Alena Moiseenko Astrid Weiss Jochen Wilhelm Jin-San Zhang Grazyna Kwapiszewska Susanne Herold Ralph T. Schermuly Bernard Mari Xiaokun Li Werner Seeger Andreas Günther Saverio Bellusci Elie El Agha
author_sort	Vahid Kheirollahi
title	Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
title_short	Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
title_full	Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
title_fullStr	Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
title_full_unstemmed	Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
title_sort	metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8abd0f7510244108a605662c2e07b3a9
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Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

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