Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

Erectile function is regulated by complex mechanisms centered on vascular- and nerve-related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED), which causes mental distress and decreases the quality of life of patients and their partners. At the molecular level, many...

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Autores principales:	Yasuyoshi Miyata, Tomohiro Matsuo, Yuichiro Nakamura, Kensuke Mitsunari, Kojiro Ohba, Hideki Sakai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	erectile dysfunction Peyronie’s disease phosphodiesterase type 5 inhibitor macrophage Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8abed85090a545428921c4f10656c94a
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spelling	oai:doaj.org-article:8abed85090a545428921c4f10656c94a2021-11-25T16:50:22ZPathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease10.3390/biomedicines91116582227-9059https://doaj.org/article/8abed85090a545428921c4f10656c94a2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1658https://doaj.org/toc/2227-9059Erectile function is regulated by complex mechanisms centered on vascular- and nerve-related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED), which causes mental distress and decreases the quality of life of patients and their partners. At the molecular level, many factors, such as fibrosis, lipid metabolism abnormalities, the immune system, and stem cells, play crucial roles in the etiology and development of ED. Although phosphodiesterase type 5 (PDE5) inhibitors are currently the standard treatment agents for patients with ED, they are effective only in a subgroup of patients. Therefore, further insight into the pathological mechanism underlying ED is needed to discuss ED treatment strategies. In this review, we focused on the biological and pathological significance of macrophages in ED because the interaction of macrophages with ED-related mechanisms have not been well explored, despite their important roles in vasculogenic and neurogenic diseases. Furthermore, we examined the pathological significance of macrophages in Peyronie’s disease (PD), a cause of ED characterized by penile deformation (visible curvature) during erection and pain. Although microinjury and the subsequent abnormal healing process of the tunica albuginea are known to be important processes in this disease, the detailed etiology and pathophysiology of PD are not fully understood. This is the first review on the pathological role of macrophages in PD.Yasuyoshi MiyataTomohiro MatsuoYuichiro NakamuraKensuke MitsunariKojiro OhbaHideki SakaiMDPI AGarticleerectile dysfunctionPeyronie’s diseasephosphodiesterase type 5 inhibitormacrophageBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1658, p 1658 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	erectile dysfunction Peyronie’s disease phosphodiesterase type 5 inhibitor macrophage Biology (General) QH301-705.5
spellingShingle	erectile dysfunction Peyronie’s disease phosphodiesterase type 5 inhibitor macrophage Biology (General) QH301-705.5 Yasuyoshi Miyata Tomohiro Matsuo Yuichiro Nakamura Kensuke Mitsunari Kojiro Ohba Hideki Sakai Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease
description	Erectile function is regulated by complex mechanisms centered on vascular- and nerve-related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED), which causes mental distress and decreases the quality of life of patients and their partners. At the molecular level, many factors, such as fibrosis, lipid metabolism abnormalities, the immune system, and stem cells, play crucial roles in the etiology and development of ED. Although phosphodiesterase type 5 (PDE5) inhibitors are currently the standard treatment agents for patients with ED, they are effective only in a subgroup of patients. Therefore, further insight into the pathological mechanism underlying ED is needed to discuss ED treatment strategies. In this review, we focused on the biological and pathological significance of macrophages in ED because the interaction of macrophages with ED-related mechanisms have not been well explored, despite their important roles in vasculogenic and neurogenic diseases. Furthermore, we examined the pathological significance of macrophages in Peyronie’s disease (PD), a cause of ED characterized by penile deformation (visible curvature) during erection and pain. Although microinjury and the subsequent abnormal healing process of the tunica albuginea are known to be important processes in this disease, the detailed etiology and pathophysiology of PD are not fully understood. This is the first review on the pathological role of macrophages in PD.
format	article
author	Yasuyoshi Miyata Tomohiro Matsuo Yuichiro Nakamura Kensuke Mitsunari Kojiro Ohba Hideki Sakai
author_facet	Yasuyoshi Miyata Tomohiro Matsuo Yuichiro Nakamura Kensuke Mitsunari Kojiro Ohba Hideki Sakai
author_sort	Yasuyoshi Miyata
title	Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease
title_short	Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease
title_full	Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease
title_fullStr	Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease
title_full_unstemmed	Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease
title_sort	pathological significance of macrophages in erectile dysfunction including peyronie’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8abed85090a545428921c4f10656c94a
work_keys_str_mv	AT yasuyoshimiyata pathologicalsignificanceofmacrophagesinerectiledysfunctionincludingpeyroniesdisease AT tomohiromatsuo pathologicalsignificanceofmacrophagesinerectiledysfunctionincludingpeyroniesdisease AT yuichironakamura pathologicalsignificanceofmacrophagesinerectiledysfunctionincludingpeyroniesdisease AT kensukemitsunari pathologicalsignificanceofmacrophagesinerectiledysfunctionincludingpeyroniesdisease AT kojiroohba pathologicalsignificanceofmacrophagesinerectiledysfunctionincludingpeyroniesdisease AT hidekisakai pathologicalsignificanceofmacrophagesinerectiledysfunctionincludingpeyroniesdisease
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Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

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