Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma

Abstract Backgroud To evaluate the changes in retinal microvasculature and retrobulbar blood flow, using optical coherence tomography angiography (OCTA) and Color Doppler imaging (CDI) after intravenous chemotherapy (IVC) in patients with retinoblastoma (RB). Methods This was a retrospective compara...

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Autores principales:	Xiuqian Yi, Jie Sun, Jiang Qian, Jie Guo, Kang Xue
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Retinoblastoma Retrobulbar ocular blood flow Optical coherence tomography angiography Intravenous chemotherapy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8abf1cd85dc04cd898166f0f7a8df86d
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spelling	oai:doaj.org-article:8abf1cd85dc04cd898166f0f7a8df86d2021-11-28T12:42:21ZQuantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma10.1186/s12886-021-02170-41471-2415https://doaj.org/article/8abf1cd85dc04cd898166f0f7a8df86d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12886-021-02170-4https://doaj.org/toc/1471-2415Abstract Backgroud To evaluate the changes in retinal microvasculature and retrobulbar blood flow, using optical coherence tomography angiography (OCTA) and Color Doppler imaging (CDI) after intravenous chemotherapy (IVC) in patients with retinoblastoma (RB). Methods This was a retrospective comparative case control series involving 30 patients. Ten bilateral RB patients that had a preserved eye with extramacular tumours (group I), 10 unilateral RB treated with IVC that had a normal fellow study eye (group II), and 10 age-matched healthy controls. The macular retinal thickness, foveal avascular zone (FAZ) area, and the macular and peripapillary retinal vessel densities (RVD) were measured. The peak systolic and end diastolic velocities of the ophthalmic, central retinal and posterior ciliary arteries were determined. A comparison among the three groups was conducted. Results Between the three cohorts, OCTA revealed no significant difference in FAZ area, superficial foveal and parafoveal RVD, deep parafoveal RVD and peripapillary RVD, (P > 0.05). By contrast, the mean deep foveal RVD, the full, inner and outer foveal and the parafoveal retinal thickness were significantly lower in group I compared with the controls, (P = 0.0329, 0.0153, 0.0311 0.0352, 0.0215). No significant difference in the blood flow velocities occurred in the retrobulbar circulation (P > 0.05). Conclusions In patients with retinoblastoma, OCTA did not detect significant changes of retinal thickness and vessel density in the eyes treated with IVC, but a slight reduction in retinal thickness and the deep foveal RVD seemed to occur in bilateral RB eyes. The retrobulbar blood flow parameters showed no measurable changes.Xiuqian YiJie SunJiang QianJie GuoKang XueBMCarticleRetinoblastomaRetrobulbar ocular blood flowOptical coherence tomography angiographyIntravenous chemotherapyOphthalmologyRE1-994ENBMC Ophthalmology, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Retinoblastoma Retrobulbar ocular blood flow Optical coherence tomography angiography Intravenous chemotherapy Ophthalmology RE1-994
spellingShingle	Retinoblastoma Retrobulbar ocular blood flow Optical coherence tomography angiography Intravenous chemotherapy Ophthalmology RE1-994 Xiuqian Yi Jie Sun Jiang Qian Jie Guo Kang Xue Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma
description	Abstract Backgroud To evaluate the changes in retinal microvasculature and retrobulbar blood flow, using optical coherence tomography angiography (OCTA) and Color Doppler imaging (CDI) after intravenous chemotherapy (IVC) in patients with retinoblastoma (RB). Methods This was a retrospective comparative case control series involving 30 patients. Ten bilateral RB patients that had a preserved eye with extramacular tumours (group I), 10 unilateral RB treated with IVC that had a normal fellow study eye (group II), and 10 age-matched healthy controls. The macular retinal thickness, foveal avascular zone (FAZ) area, and the macular and peripapillary retinal vessel densities (RVD) were measured. The peak systolic and end diastolic velocities of the ophthalmic, central retinal and posterior ciliary arteries were determined. A comparison among the three groups was conducted. Results Between the three cohorts, OCTA revealed no significant difference in FAZ area, superficial foveal and parafoveal RVD, deep parafoveal RVD and peripapillary RVD, (P > 0.05). By contrast, the mean deep foveal RVD, the full, inner and outer foveal and the parafoveal retinal thickness were significantly lower in group I compared with the controls, (P = 0.0329, 0.0153, 0.0311 0.0352, 0.0215). No significant difference in the blood flow velocities occurred in the retrobulbar circulation (P > 0.05). Conclusions In patients with retinoblastoma, OCTA did not detect significant changes of retinal thickness and vessel density in the eyes treated with IVC, but a slight reduction in retinal thickness and the deep foveal RVD seemed to occur in bilateral RB eyes. The retrobulbar blood flow parameters showed no measurable changes.
format	article
author	Xiuqian Yi Jie Sun Jiang Qian Jie Guo Kang Xue
author_facet	Xiuqian Yi Jie Sun Jiang Qian Jie Guo Kang Xue
author_sort	Xiuqian Yi
title	Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma
title_short	Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma
title_full	Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma
title_fullStr	Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma
title_full_unstemmed	Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma
title_sort	quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8abf1cd85dc04cd898166f0f7a8df86d
work_keys_str_mv	AT xiuqianyi quantitativeevaluationofretinalmicrovasculatureandretrobulbarvesselsafterintravenouschemotherapyforretinoblastoma AT jiesun quantitativeevaluationofretinalmicrovasculatureandretrobulbarvesselsafterintravenouschemotherapyforretinoblastoma AT jiangqian quantitativeevaluationofretinalmicrovasculatureandretrobulbarvesselsafterintravenouschemotherapyforretinoblastoma AT jieguo quantitativeevaluationofretinalmicrovasculatureandretrobulbarvesselsafterintravenouschemotherapyforretinoblastoma AT kangxue quantitativeevaluationofretinalmicrovasculatureandretrobulbarvesselsafterintravenouschemotherapyforretinoblastoma
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Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma

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