Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.

<h4>Background</h4>Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development.<h4>Objective</h4>Our objective was to exam...

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Autores principales:	Mandy Goldberg, Anna J Ciesielski Jones, John A McGrath, Christie Barker-Cummings, Deborah S Cousins, Lauren M Kipling, Juliana W Meadows, James S Kesner, Michele Marcus, Carolyn Monteilh, Dale P Sandler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ac1f4067c0341b88be4f7c0a08751aa
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spelling	oai:doaj.org-article:8ac1f4067c0341b88be4f7c0a08751aa2021-12-02T20:04:03ZUrinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.1932-620310.1371/journal.pone.0251598https://doaj.org/article/8ac1f4067c0341b88be4f7c0a08751aa2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251598https://doaj.org/toc/1932-6203<h4>Background</h4>Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development.<h4>Objective</h4>Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage.<h4>Methods</h4>Thirty-five girls and 42 boys aged 7 to 15 years were enrolled in the Growth and Puberty (GAP) study, a longitudinal pilot study conducted from 2007-2009 involving children of women enrolled in the Agricultural Health Study (AHS) in Iowa. We collected saliva and urine samples and assessed pubertal development by self-rated Tanner staging (pubic hair, breast development (girls), genital development (boys)) at three visits over six months. We measured dehydroepiandrosterone (DHEA) in saliva and creatinine-adjusted luteinizing hormone (LH), testosterone, follicle stimulating hormone (FSH), estrone 3-glucuronide (E13G) and pregnanediol 3-glucuronide (Pd3G) concentrations in first morning urine. We evaluated the relationships over time between Tanner stage and each biomarker using repeated measures analysis.<h4>Results</h4>Among girls still reporting Tanner breast stage 1 at the final visit, FSH levels increased over the 6-month follow-up period and were no longer lower than higher stage girls at the end of follow-up. We observed a similar pattern for testosterone in boys. By visit 3, boys still reporting Tanner genital stage 1 or pubic hair stage 1 had attained DHEA levels that were comparable to those among boys reporting Tanner stages 2 or 3.<h4>Conclusions</h4>Increasing concentrations of FSH in girls and DHEA and testosterone in boys over a 6-month period revealed the start of the pubertal process prior to changes in self-rated Tanner stage. Repeated, non-invasive endocrine measures may complement the more subjective assessment of physical markers in studies determining pubertal onset.Mandy GoldbergAnna J Ciesielski JonesJohn A McGrathChristie Barker-CummingsDeborah S CousinsLauren M KiplingJuliana W MeadowsJames S KesnerMichele MarcusCarolyn MonteilhDale P SandlerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251598 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mandy Goldberg Anna J Ciesielski Jones John A McGrath Christie Barker-Cummings Deborah S Cousins Lauren M Kipling Juliana W Meadows James S Kesner Michele Marcus Carolyn Monteilh Dale P Sandler Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.
description	<h4>Background</h4>Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development.<h4>Objective</h4>Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage.<h4>Methods</h4>Thirty-five girls and 42 boys aged 7 to 15 years were enrolled in the Growth and Puberty (GAP) study, a longitudinal pilot study conducted from 2007-2009 involving children of women enrolled in the Agricultural Health Study (AHS) in Iowa. We collected saliva and urine samples and assessed pubertal development by self-rated Tanner staging (pubic hair, breast development (girls), genital development (boys)) at three visits over six months. We measured dehydroepiandrosterone (DHEA) in saliva and creatinine-adjusted luteinizing hormone (LH), testosterone, follicle stimulating hormone (FSH), estrone 3-glucuronide (E13G) and pregnanediol 3-glucuronide (Pd3G) concentrations in first morning urine. We evaluated the relationships over time between Tanner stage and each biomarker using repeated measures analysis.<h4>Results</h4>Among girls still reporting Tanner breast stage 1 at the final visit, FSH levels increased over the 6-month follow-up period and were no longer lower than higher stage girls at the end of follow-up. We observed a similar pattern for testosterone in boys. By visit 3, boys still reporting Tanner genital stage 1 or pubic hair stage 1 had attained DHEA levels that were comparable to those among boys reporting Tanner stages 2 or 3.<h4>Conclusions</h4>Increasing concentrations of FSH in girls and DHEA and testosterone in boys over a 6-month period revealed the start of the pubertal process prior to changes in self-rated Tanner stage. Repeated, non-invasive endocrine measures may complement the more subjective assessment of physical markers in studies determining pubertal onset.
format	article
author	Mandy Goldberg Anna J Ciesielski Jones John A McGrath Christie Barker-Cummings Deborah S Cousins Lauren M Kipling Juliana W Meadows James S Kesner Michele Marcus Carolyn Monteilh Dale P Sandler
author_facet	Mandy Goldberg Anna J Ciesielski Jones John A McGrath Christie Barker-Cummings Deborah S Cousins Lauren M Kipling Juliana W Meadows James S Kesner Michele Marcus Carolyn Monteilh Dale P Sandler
author_sort	Mandy Goldberg
title	Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.
title_short	Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.
title_full	Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.
title_fullStr	Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.
title_full_unstemmed	Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.
title_sort	urinary and salivary endocrine measurements to complement tanner staging in studies of pubertal development.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8ac1f4067c0341b88be4f7c0a08751aa
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Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.

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