Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.

<h4>Background & aims</h4>Nasal obstruction caused by nasal septal deviation is very bothersome and, therefore, can affect the patient's emotional state. However, little is known about the effect of nasal septal deviation (NSD) on the neuropsychiatric aspects of patients. Theref...

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Autores principales:	Ki-Il Lee, Seung Min In, Jong-Yeup Kim, Jee-Young Hong, Kyung-Do Han, Jung-Soo Kim, Yong Gi Jung
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8aca1ed128c14425924e834a530bac76
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spelling	oai:doaj.org-article:8aca1ed128c14425924e834a530bac762021-12-02T20:04:19ZAssociation of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.1932-620310.1371/journal.pone.0259468https://doaj.org/article/8aca1ed128c14425924e834a530bac762021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259468https://doaj.org/toc/1932-6203<h4>Background & aims</h4>Nasal obstruction caused by nasal septal deviation is very bothersome and, therefore, can affect the patient's emotional state. However, little is known about the effect of nasal septal deviation (NSD) on the neuropsychiatric aspects of patients. Therefore, this study aims to verify the higher incidence of anxiety, depression, and migraine in patients diagnosed with NSD compared to general populations using big data.<h4>Methods</h4>This retrospective cohort study collected subjects from the Korean National Health Insurance Service (NHIS) database. Adjustments were made to minimize the confounding of variables for age, sex, residence type, income levels, hypertension, diabetes, dyslipidemia, rhinitis, and chronic rhinosinusitis between the two groups. The primary endpoint of this study was newly diagnosed anxiety, depression, and migraine between January 2009 and December 2018. Kaplan-Meier survival curves, logarithmic rank test, and Cox proportional regression test were used for statistical analysis.<h4>Results</h4>Among a total of 135,769 subjects in the NHIS database, 48,495 patients with NSD (NSD group) and 54,475 control subjects (control group) were selected. Patients with NSD had an increased risk of anxiety, depression, and migraine compared to the control group. In the NSD group, the adjusted hazard ratios (HR) were 1.236 (95% CI, 1.198-1.276) for anxiety, 1.289 (95% CI, 1.238-1.343) for depression, and 1.251 (95% CI, 1.214-1.290) for migraine.<h4>Conclusion</h4>NSD is associated with a higher incidence of anxiety, depression, and migraine. Therefore, it is suggested that physicians carefully consider psychoneurological distress and employ therapeutic strategies to minimize these conditions.Ki-Il LeeSeung Min InJong-Yeup KimJee-Young HongKyung-Do HanJung-Soo KimYong Gi JungPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259468 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ki-Il Lee Seung Min In Jong-Yeup Kim Jee-Young Hong Kyung-Do Han Jung-Soo Kim Yong Gi Jung Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.
description	<h4>Background & aims</h4>Nasal obstruction caused by nasal septal deviation is very bothersome and, therefore, can affect the patient's emotional state. However, little is known about the effect of nasal septal deviation (NSD) on the neuropsychiatric aspects of patients. Therefore, this study aims to verify the higher incidence of anxiety, depression, and migraine in patients diagnosed with NSD compared to general populations using big data.<h4>Methods</h4>This retrospective cohort study collected subjects from the Korean National Health Insurance Service (NHIS) database. Adjustments were made to minimize the confounding of variables for age, sex, residence type, income levels, hypertension, diabetes, dyslipidemia, rhinitis, and chronic rhinosinusitis between the two groups. The primary endpoint of this study was newly diagnosed anxiety, depression, and migraine between January 2009 and December 2018. Kaplan-Meier survival curves, logarithmic rank test, and Cox proportional regression test were used for statistical analysis.<h4>Results</h4>Among a total of 135,769 subjects in the NHIS database, 48,495 patients with NSD (NSD group) and 54,475 control subjects (control group) were selected. Patients with NSD had an increased risk of anxiety, depression, and migraine compared to the control group. In the NSD group, the adjusted hazard ratios (HR) were 1.236 (95% CI, 1.198-1.276) for anxiety, 1.289 (95% CI, 1.238-1.343) for depression, and 1.251 (95% CI, 1.214-1.290) for migraine.<h4>Conclusion</h4>NSD is associated with a higher incidence of anxiety, depression, and migraine. Therefore, it is suggested that physicians carefully consider psychoneurological distress and employ therapeutic strategies to minimize these conditions.
format	article
author	Ki-Il Lee Seung Min In Jong-Yeup Kim Jee-Young Hong Kyung-Do Han Jung-Soo Kim Yong Gi Jung
author_facet	Ki-Il Lee Seung Min In Jong-Yeup Kim Jee-Young Hong Kyung-Do Han Jung-Soo Kim Yong Gi Jung
author_sort	Ki-Il Lee
title	Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.
title_short	Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.
title_full	Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.
title_fullStr	Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.
title_full_unstemmed	Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.
title_sort	association of nasal septal deviation with the incidence of anxiety, depression, and migraine: a national population-based study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8aca1ed128c14425924e834a530bac76
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Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study.

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