Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.

<h4>Background</h4>Kaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is a natural polyphenol contained in plant-based foods. Recent studies have demonstrated that kaempferol protects against cardiovascular disease and cancer. Based on th...

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Autores principales:	Chiao-Wen Lin, Pei-Ni Chen, Mu-Kuan Chen, Wei-En Yang, Chih-Hsin Tang, Shun-Fa Yang, Yih-Shou Hsieh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8aca4accfdbc4fd999b1a55305befa3d
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spelling	oai:doaj.org-article:8aca4accfdbc4fd999b1a55305befa3d2021-11-18T08:45:25ZKaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.1932-620310.1371/journal.pone.0080883https://doaj.org/article/8aca4accfdbc4fd999b1a55305befa3d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278338/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Kaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is a natural polyphenol contained in plant-based foods. Recent studies have demonstrated that kaempferol protects against cardiovascular disease and cancer. Based on this finding, we investigated the mechanisms by which kaempferol produces the anti-metastatic effect in human tongue squamous cell carcinoma SCC4 cells.<h4>Methodology/principal findings</h4>In this study, we provided molecular evidence associated with the anti-metastatic effect of kaempferol by demonstrating a substantial suppression of SCC4 cell migration and invasion. This effect was associated with reduced expressions of MMP-2 and TIMP-2 mRNA and protein levels. Analysis of the transcriptional regulation indicated that kaempferol inhibited MMP-2 transcription by suppressing c-Jun activity. Kaempferol also produced an inhibitory effect on the phosphorylation of ERK1/2.<h4>Conclusions</h4>These findings provide new insights into the molecular mechanisms involved in the anti-metastatic effect of kaempferol, and are valuable in the prevention of oral cancer metastasis.Chiao-Wen LinPei-Ni ChenMu-Kuan ChenWei-En YangChih-Hsin TangShun-Fa YangYih-Shou HsiehPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80883 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chiao-Wen Lin Pei-Ni Chen Mu-Kuan Chen Wei-En Yang Chih-Hsin Tang Shun-Fa Yang Yih-Shou Hsieh Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.
description	<h4>Background</h4>Kaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is a natural polyphenol contained in plant-based foods. Recent studies have demonstrated that kaempferol protects against cardiovascular disease and cancer. Based on this finding, we investigated the mechanisms by which kaempferol produces the anti-metastatic effect in human tongue squamous cell carcinoma SCC4 cells.<h4>Methodology/principal findings</h4>In this study, we provided molecular evidence associated with the anti-metastatic effect of kaempferol by demonstrating a substantial suppression of SCC4 cell migration and invasion. This effect was associated with reduced expressions of MMP-2 and TIMP-2 mRNA and protein levels. Analysis of the transcriptional regulation indicated that kaempferol inhibited MMP-2 transcription by suppressing c-Jun activity. Kaempferol also produced an inhibitory effect on the phosphorylation of ERK1/2.<h4>Conclusions</h4>These findings provide new insights into the molecular mechanisms involved in the anti-metastatic effect of kaempferol, and are valuable in the prevention of oral cancer metastasis.
format	article
author	Chiao-Wen Lin Pei-Ni Chen Mu-Kuan Chen Wei-En Yang Chih-Hsin Tang Shun-Fa Yang Yih-Shou Hsieh
author_facet	Chiao-Wen Lin Pei-Ni Chen Mu-Kuan Chen Wei-En Yang Chih-Hsin Tang Shun-Fa Yang Yih-Shou Hsieh
author_sort	Chiao-Wen Lin
title	Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.
title_short	Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.
title_full	Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.
title_fullStr	Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.
title_full_unstemmed	Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.
title_sort	kaempferol reduces matrix metalloproteinase-2 expression by down-regulating erk1/2 and the activator protein-1 signaling pathways in oral cancer cells.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8aca4accfdbc4fd999b1a55305befa3d
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Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.

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