Quantifying the contribution of Neanderthal introgression to the heritability of complex traits

We lack a comprehensive understanding of how Neanderthal ancestry influences human traits. This study finds that regions with Neanderthal ancestry are broadly depleted of trait-associated variation; yet, introgressed variants likely contributed to human adaptation in a few traits, like skin color an...

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Autores principales:	Evonne McArthur, David C. Rinker, John A. Capra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8acc0daaafc348918762f887dd73867e
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spelling	oai:doaj.org-article:8acc0daaafc348918762f887dd73867e2021-12-02T16:43:31ZQuantifying the contribution of Neanderthal introgression to the heritability of complex traits10.1038/s41467-021-24582-y2041-1723https://doaj.org/article/8acc0daaafc348918762f887dd73867e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24582-yhttps://doaj.org/toc/2041-1723We lack a comprehensive understanding of how Neanderthal ancestry influences human traits. This study finds that regions with Neanderthal ancestry are broadly depleted of trait-associated variation; yet, introgressed variants likely contributed to human adaptation in a few traits, like skin color and immune response modulation.Evonne McArthurDavid C. RinkerJohn A. CapraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evonne McArthur David C. Rinker John A. Capra Quantifying the contribution of Neanderthal introgression to the heritability of complex traits
description	We lack a comprehensive understanding of how Neanderthal ancestry influences human traits. This study finds that regions with Neanderthal ancestry are broadly depleted of trait-associated variation; yet, introgressed variants likely contributed to human adaptation in a few traits, like skin color and immune response modulation.
format	article
author	Evonne McArthur David C. Rinker John A. Capra
author_facet	Evonne McArthur David C. Rinker John A. Capra
author_sort	Evonne McArthur
title	Quantifying the contribution of Neanderthal introgression to the heritability of complex traits
title_short	Quantifying the contribution of Neanderthal introgression to the heritability of complex traits
title_full	Quantifying the contribution of Neanderthal introgression to the heritability of complex traits
title_fullStr	Quantifying the contribution of Neanderthal introgression to the heritability of complex traits
title_full_unstemmed	Quantifying the contribution of Neanderthal introgression to the heritability of complex traits
title_sort	quantifying the contribution of neanderthal introgression to the heritability of complex traits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8acc0daaafc348918762f887dd73867e
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Quantifying the contribution of Neanderthal introgression to the heritability of complex traits

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