Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro

Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro

The use of genetically modified (GM) mesenchymal stromal cells (MSCs) and preconditioned MSCs (pMSCs) may provide further opportunities to improve the outcome of core decompression (CD) for the treatment of early-stage osteonecrosis of the femoral head (ONFH). GM interleukin-4 (IL4) over-expressing...

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Auteurs principaux: Masanori Tsubosaka, Masahiro Maruyama, Elijah Ejun Huang, Ning Zhang, Takeshi Utsunomiya, Qi Gao, Huaishuang Shen, Xueping Li, Junichi Kushioka, Hirohito Hirata, Zhenyu Yao, Yunzhi Peter Yang, Stuart B. Goodman
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
mesenchymal stromal cells
genetically modified
preconditioning
osteonecrosis
core decompression
Technology
T
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/8acc8113415f4067b5fcfc36b60d7aa4
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https://doaj.org/article/8acc8113415f4067b5fcfc36b60d7aa4

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