N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4

Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cells

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Autores principales:	Zihan Li, Yanxi Peng, Jiexin Li, Zhuojia Chen, Feng Chen, Jian Tu, Shuibin Lin, Hongsheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ad24c716e8548f1a29032ce576d9050
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spelling	oai:doaj.org-article:8ad24c716e8548f1a29032ce576d90502021-12-02T16:51:34ZN 6 -methyladenosine regulates glycolysis of cancer cells through PDK410.1038/s41467-020-16306-52041-1723https://doaj.org/article/8ad24c716e8548f1a29032ce576d90502020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16306-5https://doaj.org/toc/2041-1723Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cellsZihan LiYanxi PengJiexin LiZhuojia ChenFeng ChenJian TuShuibin LinHongsheng WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zihan Li Yanxi Peng Jiexin Li Zhuojia Chen Feng Chen Jian Tu Shuibin Lin Hongsheng Wang N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
description	Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cells
format	article
author	Zihan Li Yanxi Peng Jiexin Li Zhuojia Chen Feng Chen Jian Tu Shuibin Lin Hongsheng Wang
author_facet	Zihan Li Yanxi Peng Jiexin Li Zhuojia Chen Feng Chen Jian Tu Shuibin Lin Hongsheng Wang
author_sort	Zihan Li
title	N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
title_short	N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
title_full	N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
title_fullStr	N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
title_full_unstemmed	N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
title_sort	n 6 -methyladenosine regulates glycolysis of cancer cells through pdk4
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8ad24c716e8548f1a29032ce576d9050
work_keys_str_mv	AT zihanli n6methyladenosineregulatesglycolysisofcancercellsthroughpdk4 AT yanxipeng n6methyladenosineregulatesglycolysisofcancercellsthroughpdk4 AT jiexinli n6methyladenosineregulatesglycolysisofcancercellsthroughpdk4 AT zhuojiachen n6methyladenosineregulatesglycolysisofcancercellsthroughpdk4 AT fengchen n6methyladenosineregulatesglycolysisofcancercellsthroughpdk4 AT jiantu n6methyladenosineregulatesglycolysisofcancercellsthroughpdk4 AT shuibinlin n6methyladenosineregulatesglycolysisofcancercellsthroughpdk4 AT hongshengwang n6methyladenosineregulatesglycolysisofcancercellsthroughpdk4
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N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4

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