A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes

Helitron elements are proposed rolling-circle transposons in eukaryotic genomes, but experimental evidence for their transposition has been lacking. Here, Grabundzija et al. reconstruct an active Helitron from bats which they name Helraiser, and characterize its mechanism of transposition in cell-fr...

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Autores principales: Ivana Grabundzija, Simon A. Messing, Jainy Thomas, Rachel L. Cosby, Ilija Bilic, Csaba Miskey, Andreas Gogol-Döring, Vladimir Kapitonov, Tanja Diem, Anna Dalda, Jerzy Jurka, Ellen J. Pritham, Fred Dyda, Zsuzsanna Izsvák, Zoltán Ivics
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/8ad4073178cd4d31a1a49f1829a017bc
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spelling oai:doaj.org-article:8ad4073178cd4d31a1a49f1829a017bc2021-12-02T17:31:34ZA Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes10.1038/ncomms107162041-1723https://doaj.org/article/8ad4073178cd4d31a1a49f1829a017bc2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10716https://doaj.org/toc/2041-1723Helitron elements are proposed rolling-circle transposons in eukaryotic genomes, but experimental evidence for their transposition has been lacking. Here, Grabundzija et al. reconstruct an active Helitron from bats which they name Helraiser, and characterize its mechanism of transposition in cell-free reactions and in human cell cultures in vitro.Ivana GrabundzijaSimon A. MessingJainy ThomasRachel L. CosbyIlija BilicCsaba MiskeyAndreas Gogol-DöringVladimir KapitonovTanja DiemAnna DaldaJerzy JurkaEllen J. PrithamFred DydaZsuzsanna IzsvákZoltán IvicsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ivana Grabundzija
Simon A. Messing
Jainy Thomas
Rachel L. Cosby
Ilija Bilic
Csaba Miskey
Andreas Gogol-Döring
Vladimir Kapitonov
Tanja Diem
Anna Dalda
Jerzy Jurka
Ellen J. Pritham
Fred Dyda
Zsuzsanna Izsvák
Zoltán Ivics
A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
description Helitron elements are proposed rolling-circle transposons in eukaryotic genomes, but experimental evidence for their transposition has been lacking. Here, Grabundzija et al. reconstruct an active Helitron from bats which they name Helraiser, and characterize its mechanism of transposition in cell-free reactions and in human cell cultures in vitro.
format article
author Ivana Grabundzija
Simon A. Messing
Jainy Thomas
Rachel L. Cosby
Ilija Bilic
Csaba Miskey
Andreas Gogol-Döring
Vladimir Kapitonov
Tanja Diem
Anna Dalda
Jerzy Jurka
Ellen J. Pritham
Fred Dyda
Zsuzsanna Izsvák
Zoltán Ivics
author_facet Ivana Grabundzija
Simon A. Messing
Jainy Thomas
Rachel L. Cosby
Ilija Bilic
Csaba Miskey
Andreas Gogol-Döring
Vladimir Kapitonov
Tanja Diem
Anna Dalda
Jerzy Jurka
Ellen J. Pritham
Fred Dyda
Zsuzsanna Izsvák
Zoltán Ivics
author_sort Ivana Grabundzija
title A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
title_short A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
title_full A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
title_fullStr A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
title_full_unstemmed A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
title_sort helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/8ad4073178cd4d31a1a49f1829a017bc
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