MafB is a critical regulator of complement component C1q

Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.

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Autores principales:	Mai Thi Nhu Tran, Michito Hamada, Hyojung Jeon, Risako Shiraishi, Keigo Asano, Motochika Hattori, Megumi Nakamura, Yuki Imamura, Yuki Tsunakawa, Risa Fujii, Toshiaki Usui, Kaushalya Kulathunga, Christina-Sylvia Andrea, Ryusuke Koshida, Risa Kamei, Yurina Matsunaga, Makoto Kobayashi, Hisashi Oishi, Takashi Kudo, Satoru Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ad6548fe15640be8a3fcc672a1b03f2
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spelling	oai:doaj.org-article:8ad6548fe15640be8a3fcc672a1b03f22021-12-02T15:38:46ZMafB is a critical regulator of complement component C1q10.1038/s41467-017-01711-02041-1723https://doaj.org/article/8ad6548fe15640be8a3fcc672a1b03f22017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01711-0https://doaj.org/toc/2041-1723Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.Mai Thi Nhu TranMichito HamadaHyojung JeonRisako ShiraishiKeigo AsanoMotochika HattoriMegumi NakamuraYuki ImamuraYuki TsunakawaRisa FujiiToshiaki UsuiKaushalya KulathungaChristina-Sylvia AndreaRyusuke KoshidaRisa KameiYurina MatsunagaMakoto KobayashiHisashi OishiTakashi KudoSatoru TakahashiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mai Thi Nhu Tran Michito Hamada Hyojung Jeon Risako Shiraishi Keigo Asano Motochika Hattori Megumi Nakamura Yuki Imamura Yuki Tsunakawa Risa Fujii Toshiaki Usui Kaushalya Kulathunga Christina-Sylvia Andrea Ryusuke Koshida Risa Kamei Yurina Matsunaga Makoto Kobayashi Hisashi Oishi Takashi Kudo Satoru Takahashi MafB is a critical regulator of complement component C1q
description	Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.
format	article
author	Mai Thi Nhu Tran Michito Hamada Hyojung Jeon Risako Shiraishi Keigo Asano Motochika Hattori Megumi Nakamura Yuki Imamura Yuki Tsunakawa Risa Fujii Toshiaki Usui Kaushalya Kulathunga Christina-Sylvia Andrea Ryusuke Koshida Risa Kamei Yurina Matsunaga Makoto Kobayashi Hisashi Oishi Takashi Kudo Satoru Takahashi
author_facet	Mai Thi Nhu Tran Michito Hamada Hyojung Jeon Risako Shiraishi Keigo Asano Motochika Hattori Megumi Nakamura Yuki Imamura Yuki Tsunakawa Risa Fujii Toshiaki Usui Kaushalya Kulathunga Christina-Sylvia Andrea Ryusuke Koshida Risa Kamei Yurina Matsunaga Makoto Kobayashi Hisashi Oishi Takashi Kudo Satoru Takahashi
author_sort	Mai Thi Nhu Tran
title	MafB is a critical regulator of complement component C1q
title_short	MafB is a critical regulator of complement component C1q
title_full	MafB is a critical regulator of complement component C1q
title_fullStr	MafB is a critical regulator of complement component C1q
title_full_unstemmed	MafB is a critical regulator of complement component C1q
title_sort	mafb is a critical regulator of complement component c1q
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8ad6548fe15640be8a3fcc672a1b03f2
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MafB is a critical regulator of complement component C1q

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