Leiomyosarcoma of the upper respiratory tract: A case report and review of literature

Introduction. Leiomyosarcoma is a malignant smooth muscle tumor that is most often found in the gastrointestinal tract, uterus, and retroperitoneum. It is uncommon in the upper respiratory tract. Case report. A 53-year-old woman sought treatment for a 3-month history of nasal obstruction and facial...

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Autores principales:	Milić-Perović Marija, Šolajić Nenad, Rakić Nebojša, Vučković-Hardi Lidija
Formato:	article
Lenguaje:	EN SR
Publicado:	Military Health Department, Ministry of Defance, Serbia 2021
Materias:	diagnosis, differential leiomyosarcoma histological techniques otorhinolaryngologic surgical procedures pharyngeal neoplasms respiratory system survival Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8ad71db6d3f84139ace436ed39adafaf
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spelling	oai:doaj.org-article:8ad71db6d3f84139ace436ed39adafaf2021-12-01T13:00:25ZLeiomyosarcoma of the upper respiratory tract: A case report and review of literature0042-84502406-072010.2298/VSP190826057Mhttps://doaj.org/article/8ad71db6d3f84139ace436ed39adafaf2021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000057M.pdfhttps://doaj.org/toc/0042-8450https://doaj.org/toc/2406-0720Introduction. Leiomyosarcoma is a malignant smooth muscle tumor that is most often found in the gastrointestinal tract, uterus, and retroperitoneum. It is uncommon in the upper respiratory tract. Case report. A 53-year-old woman sought treatment for a 3-month history of nasal obstruction and facial pain. An endoscopic examination revealed a polypoid mass involving the right nasal cavity. The patient was operated on. During surgery, a bulky tumor mass was found, which involved the posterior part of the right inferior concha projecting into the lumen of the epipharynx and upper part of the oropharynx. The lesion was completely excised with adequate margins of uninvolved tissue. Histologic slides stained with hematoxylin and eosin showed interlacing fascicles of atypical spindle-shaped cells. Mitotic figures and bizarre giant cells were frequently observed. Immunohistochemical staining revealed that the tumor was positive for smooth muscle actin and h-caldesmon and negative for S-100. Histological and immunohistochemical features were consistent with leiomyosarcoma. The follow-up was regularly performed by nasal endoscopy and computed tomography, and the disease-free period has been 53 months so far. Conclusion. To the best of our knowledge, this is the longest disease-free period in a patient with leiomyosarcoma of the upper respiratory tract since 1996. This tumor has obscure clinical behavior and prognosis, thus we believe it is necessary to have more published data to determine the best combination of existing therapies, as well as potential new therapies, and enable a longer survival period.Milić-Perović MarijaŠolajić NenadRakić NebojšaVučković-Hardi LidijaMilitary Health Department, Ministry of Defance, Serbiaarticlediagnosis, differentialleiomyosarcomahistological techniquesotorhinolaryngologic surgical procedurespharyngeal neoplasmsrespiratory systemsurvivalMedicine (General)R5-920ENSRVojnosanitetski Pregled, Vol 78, Iss 11, Pp 1234-1237 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	diagnosis, differential leiomyosarcoma histological techniques otorhinolaryngologic surgical procedures pharyngeal neoplasms respiratory system survival Medicine (General) R5-920
spellingShingle	diagnosis, differential leiomyosarcoma histological techniques otorhinolaryngologic surgical procedures pharyngeal neoplasms respiratory system survival Medicine (General) R5-920 Milić-Perović Marija Šolajić Nenad Rakić Nebojša Vučković-Hardi Lidija Leiomyosarcoma of the upper respiratory tract: A case report and review of literature
description	Introduction. Leiomyosarcoma is a malignant smooth muscle tumor that is most often found in the gastrointestinal tract, uterus, and retroperitoneum. It is uncommon in the upper respiratory tract. Case report. A 53-year-old woman sought treatment for a 3-month history of nasal obstruction and facial pain. An endoscopic examination revealed a polypoid mass involving the right nasal cavity. The patient was operated on. During surgery, a bulky tumor mass was found, which involved the posterior part of the right inferior concha projecting into the lumen of the epipharynx and upper part of the oropharynx. The lesion was completely excised with adequate margins of uninvolved tissue. Histologic slides stained with hematoxylin and eosin showed interlacing fascicles of atypical spindle-shaped cells. Mitotic figures and bizarre giant cells were frequently observed. Immunohistochemical staining revealed that the tumor was positive for smooth muscle actin and h-caldesmon and negative for S-100. Histological and immunohistochemical features were consistent with leiomyosarcoma. The follow-up was regularly performed by nasal endoscopy and computed tomography, and the disease-free period has been 53 months so far. Conclusion. To the best of our knowledge, this is the longest disease-free period in a patient with leiomyosarcoma of the upper respiratory tract since 1996. This tumor has obscure clinical behavior and prognosis, thus we believe it is necessary to have more published data to determine the best combination of existing therapies, as well as potential new therapies, and enable a longer survival period.
format	article
author	Milić-Perović Marija Šolajić Nenad Rakić Nebojša Vučković-Hardi Lidija
author_facet	Milić-Perović Marija Šolajić Nenad Rakić Nebojša Vučković-Hardi Lidija
author_sort	Milić-Perović Marija
title	Leiomyosarcoma of the upper respiratory tract: A case report and review of literature
title_short	Leiomyosarcoma of the upper respiratory tract: A case report and review of literature
title_full	Leiomyosarcoma of the upper respiratory tract: A case report and review of literature
title_fullStr	Leiomyosarcoma of the upper respiratory tract: A case report and review of literature
title_full_unstemmed	Leiomyosarcoma of the upper respiratory tract: A case report and review of literature
title_sort	leiomyosarcoma of the upper respiratory tract: a case report and review of literature
publisher	Military Health Department, Ministry of Defance, Serbia
publishDate	2021
url	https://doaj.org/article/8ad71db6d3f84139ace436ed39adafaf
work_keys_str_mv	AT milicperovicmarija leiomyosarcomaoftheupperrespiratorytractacasereportandreviewofliterature AT solajicnenad leiomyosarcomaoftheupperrespiratorytractacasereportandreviewofliterature AT rakicnebojsa leiomyosarcomaoftheupperrespiratorytractacasereportandreviewofliterature AT vuckovichardilidija leiomyosarcomaoftheupperrespiratorytractacasereportandreviewofliterature
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Leiomyosarcoma of the upper respiratory tract: A case report and review of literature

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