VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

Macrophage differentiation and inflammatory function are controlled by cell metabolism. Here, the authors use a viral hepatitis model and a high-fat diet model of insulin resistance to show how VSIG4 inhibits inflammatory macrophage activation by modulating mitochondrial pyruvate metabolism.

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Autores principales:	Jialin Li, Bo Diao, Sheng Guo, Xiaoyong Huang, Chengying Yang, Zeqing Feng, Weiming Yan, Qin Ning, Lixin Zheng, Yongwen Chen, Yuzhang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ada1b0bc7f44e859e5f7bb532df5761
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:8ada1b0bc7f44e859e5f7bb532df57612021-12-02T15:37:06ZVSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism10.1038/s41467-017-01327-42041-1723https://doaj.org/article/8ada1b0bc7f44e859e5f7bb532df57612017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01327-4https://doaj.org/toc/2041-1723Macrophage differentiation and inflammatory function are controlled by cell metabolism. Here, the authors use a viral hepatitis model and a high-fat diet model of insulin resistance to show how VSIG4 inhibits inflammatory macrophage activation by modulating mitochondrial pyruvate metabolism.Jialin LiBo DiaoSheng GuoXiaoyong HuangChengying YangZeqing FengWeiming YanQin NingLixin ZhengYongwen ChenYuzhang WuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jialin Li Bo Diao Sheng Guo Xiaoyong Huang Chengying Yang Zeqing Feng Weiming Yan Qin Ning Lixin Zheng Yongwen Chen Yuzhang Wu VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
description	Macrophage differentiation and inflammatory function are controlled by cell metabolism. Here, the authors use a viral hepatitis model and a high-fat diet model of insulin resistance to show how VSIG4 inhibits inflammatory macrophage activation by modulating mitochondrial pyruvate metabolism.
format	article
author	Jialin Li Bo Diao Sheng Guo Xiaoyong Huang Chengying Yang Zeqing Feng Weiming Yan Qin Ning Lixin Zheng Yongwen Chen Yuzhang Wu
author_facet	Jialin Li Bo Diao Sheng Guo Xiaoyong Huang Chengying Yang Zeqing Feng Weiming Yan Qin Ning Lixin Zheng Yongwen Chen Yuzhang Wu
author_sort	Jialin Li
title	VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
title_short	VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
title_full	VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
title_fullStr	VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
title_full_unstemmed	VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
title_sort	vsig4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8ada1b0bc7f44e859e5f7bb532df5761
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VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

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