Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation

Introduction: The oxidative process in severe clinically ill patient with mechanical ventilation, base the possible association of serum uric acid with mortality and morbidity. Objectives: To identify the possible association of serum uric acid with the mortality and morbidity of severe clinically i...

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Autores principales:	Wilfredo Hernández Pedroso, José Luis Pérez Alejo, Aliusha Rittoles Navarro, Leticia del Rosario Cruz, Efraín Felipe Chibás Ponce
Formato:	article
Lenguaje:	ES
Publicado:	ECIMED 2021
Materias:	ácido úrico ventilación mecánica invasiva cuidados intensivos. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8ada9bb981254b6c9d446c7a56d694c6
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spelling	oai:doaj.org-article:8ada9bb981254b6c9d446c7a56d694c62021-11-30T13:31:08ZRelationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation1561-3046https://doaj.org/article/8ada9bb981254b6c9d446c7a56d694c62021-10-01T00:00:00Zhttp://www.revmedmilitar.sld.cu/index.php/mil/article/view/1172https://doaj.org/toc/1561-3046Introduction: The oxidative process in severe clinically ill patient with mechanical ventilation, base the possible association of serum uric acid with mortality and morbidity. Objectives: To identify the possible association of serum uric acid with the mortality and morbidity of severe clinically ill patients with invasive mechanical ventilation. Methods: A longitudinal and prospective observational study was carried out in 89 patients with invasive mechanical ventilation, admitted to the intensive care unit of the Hospital "Dr. Luís Díaz Soto", from January 2000 to August 2007. On admission and for three consecutive days, the serum uric acid was determined with a Hitachi 902 microprocessor. The mean value was contrasted with mortality, morbidity, and mechanical ventilation time. Quantitative variables were expressed as mean and standard deviation; the comparison of means was made with Student's t test. Qualitative variables were expressed with absolute frequencies and percentages; the association was evaluated with the chi square. Results: Male sex predominated (58,4 %) and mean age of 51,2 ± 14,9 years. The most frequent diagnosis on admission was sepsis (47,1 %). The mortality was 59,6 % and 66,3% in the hospital. The higher value of uric acid was associated to hospital mortality, the multiple organ damage syndrome (316,8 ± 165 mmol/l p=0,04) and the longer mechanical ventilation time (307,3 ± 157 mmol/l p=0,016). Conclusions: The association of mortality and morbidity, with serum uric acid on admission, was evident in severe clinical patients with mechanical ventilation.Wilfredo Hernández PedrosoJosé Luis Pérez AlejoAliusha Rittoles NavarroLeticia del Rosario CruzEfraín Felipe Chibás PonceECIMEDarticleácido úricoventilación mecánica invasivacuidados intensivos.MedicineRMedicine (General)R5-920ESRevista Cubana de Medicina Militar, Vol 50, Iss 4, Pp e02101172-e02101172 (2021)
institution	DOAJ
collection	DOAJ
language	ES
topic	ácido úrico ventilación mecánica invasiva cuidados intensivos. Medicine R Medicine (General) R5-920
spellingShingle	ácido úrico ventilación mecánica invasiva cuidados intensivos. Medicine R Medicine (General) R5-920 Wilfredo Hernández Pedroso José Luis Pérez Alejo Aliusha Rittoles Navarro Leticia del Rosario Cruz Efraín Felipe Chibás Ponce Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation
description	Introduction: The oxidative process in severe clinically ill patient with mechanical ventilation, base the possible association of serum uric acid with mortality and morbidity. Objectives: To identify the possible association of serum uric acid with the mortality and morbidity of severe clinically ill patients with invasive mechanical ventilation. Methods: A longitudinal and prospective observational study was carried out in 89 patients with invasive mechanical ventilation, admitted to the intensive care unit of the Hospital "Dr. Luís Díaz Soto", from January 2000 to August 2007. On admission and for three consecutive days, the serum uric acid was determined with a Hitachi 902 microprocessor. The mean value was contrasted with mortality, morbidity, and mechanical ventilation time. Quantitative variables were expressed as mean and standard deviation; the comparison of means was made with Student's t test. Qualitative variables were expressed with absolute frequencies and percentages; the association was evaluated with the chi square. Results: Male sex predominated (58,4 %) and mean age of 51,2 ± 14,9 years. The most frequent diagnosis on admission was sepsis (47,1 %). The mortality was 59,6 % and 66,3% in the hospital. The higher value of uric acid was associated to hospital mortality, the multiple organ damage syndrome (316,8 ± 165 mmol/l p=0,04) and the longer mechanical ventilation time (307,3 ± 157 mmol/l p=0,016). Conclusions: The association of mortality and morbidity, with serum uric acid on admission, was evident in severe clinical patients with mechanical ventilation.
format	article
author	Wilfredo Hernández Pedroso José Luis Pérez Alejo Aliusha Rittoles Navarro Leticia del Rosario Cruz Efraín Felipe Chibás Ponce
author_facet	Wilfredo Hernández Pedroso José Luis Pérez Alejo Aliusha Rittoles Navarro Leticia del Rosario Cruz Efraín Felipe Chibás Ponce
author_sort	Wilfredo Hernández Pedroso
title	Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation
title_short	Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation
title_full	Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation
title_fullStr	Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation
title_full_unstemmed	Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation
title_sort	relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation
publisher	ECIMED
publishDate	2021
url	https://doaj.org/article/8ada9bb981254b6c9d446c7a56d694c6
work_keys_str_mv	AT wilfredohernandezpedroso relationshipofserumuricacidlevelswithmortalityandmorbidityincriticallyillpatientswithmechanicalventilation AT joseluisperezalejo relationshipofserumuricacidlevelswithmortalityandmorbidityincriticallyillpatientswithmechanicalventilation AT aliusharittolesnavarro relationshipofserumuricacidlevelswithmortalityandmorbidityincriticallyillpatientswithmechanicalventilation AT leticiadelrosariocruz relationshipofserumuricacidlevelswithmortalityandmorbidityincriticallyillpatientswithmechanicalventilation AT efrainfelipechibasponce relationshipofserumuricacidlevelswithmortalityandmorbidityincriticallyillpatientswithmechanicalventilation
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Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation

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