Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks

Biodegradable triblock copolymers based on poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) were synthesized via ring-opening polymerization of L-lactide followed by reversible addition–fragmentation chain-transfer (RAFT) polymerization of poly(methyl vinyl ketone) (PMVK) as a photodegradable...

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Autores principales: Taeyoon Kim, Sorim Lee, Soo-Yong Park, Ildoo Chung
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:8adeaa3ce76b4b64a5821f57acc676a42021-11-25T18:48:49ZBiodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks10.3390/polym132239642073-4360https://doaj.org/article/8adeaa3ce76b4b64a5821f57acc676a42021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3964https://doaj.org/toc/2073-4360Biodegradable triblock copolymers based on poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) were synthesized via ring-opening polymerization of L-lactide followed by reversible addition–fragmentation chain-transfer (RAFT) polymerization of poly(methyl vinyl ketone) (PMVK) as a photodegradable block, and characterized by FT-IR and <sup>1</sup>H NMR spectroscopy for structural analyses, and by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) for their thermal properties. Porous, biodegradable PCL-b-PLA microspheres were fabricated via the oil/water (O/W) emulsion evaporation method, followed by photodegradation of PMVK blocks by UV irradiation. The macro-chain transfer agent (CTA) synthesized by reacting a carboxylic-acid-terminated CTA—S-1-dodecyl-S′-(a,a′-dimethyl-a′′-acetic acid)trithiocarbonate (DDMAT)—with a hydroxyl-terminated PCL-b-PLA block copolymer was used to synthesize well-defined triblock copolymers with methyl vinyl ketone via RAFT polymerization with controlled molecular weights and narrow polydispersity. Gel permeation chromatography traces indicated that the molecular weight of the triblock copolymer decreased with UV irradiation time because of the photodegradation of the PMVK blocks. The morphology of the microspheres before and after UV irradiation was investigated using SEM and videos of three-dimensional confocal laser microscopy, showing a change in their surface texture from smooth to rough, with high porosity owing to the photodegradation of the PMVK blocks to become porous templates.Taeyoon KimSorim LeeSoo-Yong ParkIldoo ChungMDPI AGarticlephotodegradationblock copolymerRAFTMVKporous polymerOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3964, p 3964 (2021)
institution DOAJ
collection DOAJ
language EN
topic photodegradation
block copolymer
RAFT
MVK
porous polymer
Organic chemistry
QD241-441
spellingShingle photodegradation
block copolymer
RAFT
MVK
porous polymer
Organic chemistry
QD241-441
Taeyoon Kim
Sorim Lee
Soo-Yong Park
Ildoo Chung
Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks
description Biodegradable triblock copolymers based on poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) were synthesized via ring-opening polymerization of L-lactide followed by reversible addition–fragmentation chain-transfer (RAFT) polymerization of poly(methyl vinyl ketone) (PMVK) as a photodegradable block, and characterized by FT-IR and <sup>1</sup>H NMR spectroscopy for structural analyses, and by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) for their thermal properties. Porous, biodegradable PCL-b-PLA microspheres were fabricated via the oil/water (O/W) emulsion evaporation method, followed by photodegradation of PMVK blocks by UV irradiation. The macro-chain transfer agent (CTA) synthesized by reacting a carboxylic-acid-terminated CTA—S-1-dodecyl-S′-(a,a′-dimethyl-a′′-acetic acid)trithiocarbonate (DDMAT)—with a hydroxyl-terminated PCL-b-PLA block copolymer was used to synthesize well-defined triblock copolymers with methyl vinyl ketone via RAFT polymerization with controlled molecular weights and narrow polydispersity. Gel permeation chromatography traces indicated that the molecular weight of the triblock copolymer decreased with UV irradiation time because of the photodegradation of the PMVK blocks. The morphology of the microspheres before and after UV irradiation was investigated using SEM and videos of three-dimensional confocal laser microscopy, showing a change in their surface texture from smooth to rough, with high porosity owing to the photodegradation of the PMVK blocks to become porous templates.
format article
author Taeyoon Kim
Sorim Lee
Soo-Yong Park
Ildoo Chung
author_facet Taeyoon Kim
Sorim Lee
Soo-Yong Park
Ildoo Chung
author_sort Taeyoon Kim
title Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks
title_short Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks
title_full Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks
title_fullStr Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks
title_full_unstemmed Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks
title_sort biodegradable pcl-b-pla microspheres with nanopores prepared via raft polymerization and uv photodegradation of poly(methyl vinyl ketone) blocks
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/8adeaa3ce76b4b64a5821f57acc676a4
work_keys_str_mv AT taeyoonkim biodegradablepclbplamicrosphereswithnanoporespreparedviaraftpolymerizationanduvphotodegradationofpolymethylvinylketoneblocks
AT sorimlee biodegradablepclbplamicrosphereswithnanoporespreparedviaraftpolymerizationanduvphotodegradationofpolymethylvinylketoneblocks
AT sooyongpark biodegradablepclbplamicrosphereswithnanoporespreparedviaraftpolymerizationanduvphotodegradationofpolymethylvinylketoneblocks
AT ildoochung biodegradablepclbplamicrosphereswithnanoporespreparedviaraftpolymerizationanduvphotodegradationofpolymethylvinylketoneblocks
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