Topical tacrolimus for the treatment of secondary lymphedema

Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.

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Auteurs principaux:	Jason C. Gardenier, Raghu P. Kataru, Geoffrey E. Hespe, Ira L. Savetsky, Jeremy S. Torrisi, Gabriela D. García Nores, Dawit K. Jowhar, Matthew D. Nitti, Ryan C. Schofield, Dean C. Carlow, Babak J. Mehrara
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/8ae0ff4c3d0e4e30a638ec12178b9f93
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spelling	oai:doaj.org-article:8ae0ff4c3d0e4e30a638ec12178b9f932021-12-02T16:51:47ZTopical tacrolimus for the treatment of secondary lymphedema10.1038/ncomms143452041-1723https://doaj.org/article/8ae0ff4c3d0e4e30a638ec12178b9f932017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14345https://doaj.org/toc/2041-1723Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.Jason C. GardenierRaghu P. KataruGeoffrey E. HespeIra L. SavetskyJeremy S. TorrisiGabriela D. García NoresDawit K. JowharMatthew D. NittiRyan C. SchofieldDean C. CarlowBabak J. MehraraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason C. Gardenier Raghu P. Kataru Geoffrey E. Hespe Ira L. Savetsky Jeremy S. Torrisi Gabriela D. García Nores Dawit K. Jowhar Matthew D. Nitti Ryan C. Schofield Dean C. Carlow Babak J. Mehrara Topical tacrolimus for the treatment of secondary lymphedema
description	Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.
format	article
author	Jason C. Gardenier Raghu P. Kataru Geoffrey E. Hespe Ira L. Savetsky Jeremy S. Torrisi Gabriela D. García Nores Dawit K. Jowhar Matthew D. Nitti Ryan C. Schofield Dean C. Carlow Babak J. Mehrara
author_facet	Jason C. Gardenier Raghu P. Kataru Geoffrey E. Hespe Ira L. Savetsky Jeremy S. Torrisi Gabriela D. García Nores Dawit K. Jowhar Matthew D. Nitti Ryan C. Schofield Dean C. Carlow Babak J. Mehrara
author_sort	Jason C. Gardenier
title	Topical tacrolimus for the treatment of secondary lymphedema
title_short	Topical tacrolimus for the treatment of secondary lymphedema
title_full	Topical tacrolimus for the treatment of secondary lymphedema
title_fullStr	Topical tacrolimus for the treatment of secondary lymphedema
title_full_unstemmed	Topical tacrolimus for the treatment of secondary lymphedema
title_sort	topical tacrolimus for the treatment of secondary lymphedema
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8ae0ff4c3d0e4e30a638ec12178b9f93
work_keys_str_mv	AT jasoncgardenier topicaltacrolimusforthetreatmentofsecondarylymphedema AT raghupkataru topicaltacrolimusforthetreatmentofsecondarylymphedema AT geoffreyehespe topicaltacrolimusforthetreatmentofsecondarylymphedema AT iralsavetsky topicaltacrolimusforthetreatmentofsecondarylymphedema AT jeremystorrisi topicaltacrolimusforthetreatmentofsecondarylymphedema AT gabrieladgarcianores topicaltacrolimusforthetreatmentofsecondarylymphedema AT dawitkjowhar topicaltacrolimusforthetreatmentofsecondarylymphedema AT matthewdnitti topicaltacrolimusforthetreatmentofsecondarylymphedema AT ryancschofield topicaltacrolimusforthetreatmentofsecondarylymphedema AT deanccarlow topicaltacrolimusforthetreatmentofsecondarylymphedema AT babakjmehrara topicaltacrolimusforthetreatmentofsecondarylymphedema
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Topical tacrolimus for the treatment of secondary lymphedema

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