Topical tacrolimus for the treatment of secondary lymphedema

Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.

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Autores principales: Jason C. Gardenier, Raghu P. Kataru, Geoffrey E. Hespe, Ira L. Savetsky, Jeremy S. Torrisi, Gabriela D. García Nores, Dawit K. Jowhar, Matthew D. Nitti, Ryan C. Schofield, Dean C. Carlow, Babak J. Mehrara
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8ae0ff4c3d0e4e30a638ec12178b9f93
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spelling oai:doaj.org-article:8ae0ff4c3d0e4e30a638ec12178b9f932021-12-02T16:51:47ZTopical tacrolimus for the treatment of secondary lymphedema10.1038/ncomms143452041-1723https://doaj.org/article/8ae0ff4c3d0e4e30a638ec12178b9f932017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14345https://doaj.org/toc/2041-1723Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.Jason C. GardenierRaghu P. KataruGeoffrey E. HespeIra L. SavetskyJeremy S. TorrisiGabriela D. García NoresDawit K. JowharMatthew D. NittiRyan C. SchofieldDean C. CarlowBabak J. MehraraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jason C. Gardenier
Raghu P. Kataru
Geoffrey E. Hespe
Ira L. Savetsky
Jeremy S. Torrisi
Gabriela D. García Nores
Dawit K. Jowhar
Matthew D. Nitti
Ryan C. Schofield
Dean C. Carlow
Babak J. Mehrara
Topical tacrolimus for the treatment of secondary lymphedema
description Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.
format article
author Jason C. Gardenier
Raghu P. Kataru
Geoffrey E. Hespe
Ira L. Savetsky
Jeremy S. Torrisi
Gabriela D. García Nores
Dawit K. Jowhar
Matthew D. Nitti
Ryan C. Schofield
Dean C. Carlow
Babak J. Mehrara
author_facet Jason C. Gardenier
Raghu P. Kataru
Geoffrey E. Hespe
Ira L. Savetsky
Jeremy S. Torrisi
Gabriela D. García Nores
Dawit K. Jowhar
Matthew D. Nitti
Ryan C. Schofield
Dean C. Carlow
Babak J. Mehrara
author_sort Jason C. Gardenier
title Topical tacrolimus for the treatment of secondary lymphedema
title_short Topical tacrolimus for the treatment of secondary lymphedema
title_full Topical tacrolimus for the treatment of secondary lymphedema
title_fullStr Topical tacrolimus for the treatment of secondary lymphedema
title_full_unstemmed Topical tacrolimus for the treatment of secondary lymphedema
title_sort topical tacrolimus for the treatment of secondary lymphedema
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8ae0ff4c3d0e4e30a638ec12178b9f93
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