Topical tacrolimus for the treatment of secondary lymphedema
Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.
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Nature Portfolio
2017
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oai:doaj.org-article:8ae0ff4c3d0e4e30a638ec12178b9f932021-12-02T16:51:47ZTopical tacrolimus for the treatment of secondary lymphedema10.1038/ncomms143452041-1723https://doaj.org/article/8ae0ff4c3d0e4e30a638ec12178b9f932017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14345https://doaj.org/toc/2041-1723Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.Jason C. GardenierRaghu P. KataruGeoffrey E. HespeIra L. SavetskyJeremy S. TorrisiGabriela D. García NoresDawit K. JowharMatthew D. NittiRyan C. SchofieldDean C. CarlowBabak J. MehraraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
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DOAJ |
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DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Jason C. Gardenier Raghu P. Kataru Geoffrey E. Hespe Ira L. Savetsky Jeremy S. Torrisi Gabriela D. García Nores Dawit K. Jowhar Matthew D. Nitti Ryan C. Schofield Dean C. Carlow Babak J. Mehrara Topical tacrolimus for the treatment of secondary lymphedema |
description |
Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients. |
format |
article |
author |
Jason C. Gardenier Raghu P. Kataru Geoffrey E. Hespe Ira L. Savetsky Jeremy S. Torrisi Gabriela D. García Nores Dawit K. Jowhar Matthew D. Nitti Ryan C. Schofield Dean C. Carlow Babak J. Mehrara |
author_facet |
Jason C. Gardenier Raghu P. Kataru Geoffrey E. Hespe Ira L. Savetsky Jeremy S. Torrisi Gabriela D. García Nores Dawit K. Jowhar Matthew D. Nitti Ryan C. Schofield Dean C. Carlow Babak J. Mehrara |
author_sort |
Jason C. Gardenier |
title |
Topical tacrolimus for the treatment of secondary lymphedema |
title_short |
Topical tacrolimus for the treatment of secondary lymphedema |
title_full |
Topical tacrolimus for the treatment of secondary lymphedema |
title_fullStr |
Topical tacrolimus for the treatment of secondary lymphedema |
title_full_unstemmed |
Topical tacrolimus for the treatment of secondary lymphedema |
title_sort |
topical tacrolimus for the treatment of secondary lymphedema |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/8ae0ff4c3d0e4e30a638ec12178b9f93 |
work_keys_str_mv |
AT jasoncgardenier topicaltacrolimusforthetreatmentofsecondarylymphedema AT raghupkataru topicaltacrolimusforthetreatmentofsecondarylymphedema AT geoffreyehespe topicaltacrolimusforthetreatmentofsecondarylymphedema AT iralsavetsky topicaltacrolimusforthetreatmentofsecondarylymphedema AT jeremystorrisi topicaltacrolimusforthetreatmentofsecondarylymphedema AT gabrieladgarcianores topicaltacrolimusforthetreatmentofsecondarylymphedema AT dawitkjowhar topicaltacrolimusforthetreatmentofsecondarylymphedema AT matthewdnitti topicaltacrolimusforthetreatmentofsecondarylymphedema AT ryancschofield topicaltacrolimusforthetreatmentofsecondarylymphedema AT deanccarlow topicaltacrolimusforthetreatmentofsecondarylymphedema AT babakjmehrara topicaltacrolimusforthetreatmentofsecondarylymphedema |
_version_ |
1718382931804684288 |