Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease

Abstract Plasma levels of fatty acid binding protein 3 (pFABP3) are elevated in patients with peripheral artery disease (PAD). Since the kidney filters FABP3 from circulation, we investigated whether urinary fatty acid binding protein 3 (uFABP3) is associated with PAD, and also explored its potentia...

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Autores principales:	Abdelrahman Zamzam, Muzammil H. Syed, John Harlock, John Eikelboom, Krishna K. Singh, Rawand Abdin, Mohammad Qadura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ae211f7b4094becb723ab7f42cf61d3
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spelling	oai:doaj.org-article:8ae211f7b4094becb723ab7f42cf61d32021-12-02T14:49:18ZUrinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease10.1038/s41598-021-90395-02045-2322https://doaj.org/article/8ae211f7b4094becb723ab7f42cf61d32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90395-0https://doaj.org/toc/2045-2322Abstract Plasma levels of fatty acid binding protein 3 (pFABP3) are elevated in patients with peripheral artery disease (PAD). Since the kidney filters FABP3 from circulation, we investigated whether urinary fatty acid binding protein 3 (uFABP3) is associated with PAD, and also explored its potential as a diagnostic biomarker for this disease state. A total of 130 patients were recruited from outpatient clinics at St. Michael’s Hospital, comprising of 65 patients with PAD and 65 patients without PAD (non-PAD). Levels of uFABP3 normalized for urine creatinine (uFABP3/uCr) were 1.7-folds higher in patients with PAD [median (IQR) 4.41 (2.79–8.08)] compared with non-PAD controls [median (IQR) 2.49 (1.78–3.12), p-value = 0.001]. Subgroup analysis demonstrated no significant effect of cardiovascular risk factors (age, sex, hypertension, hypercholesteremia, diabetes and smoking) on uFABP3/uCr in both PAD and non-PAD patients. Spearmen correlation studies demonstrated a significant negative correlation between uFABP3/uCr and ABI (ρ = − 0.436; p-value = 0.001). Regression analysis demonstrated that uFABP3/Cr levels were associated with PAD independently of age, sex, hypercholesterolemia, smoking, prior history of coronary arterial disease and Estimated Glomerular Filtration rate (eGFR) [odds ratio: 2.34 (95% confidence interval: 1.47–3.75) p-value < 0.001]. Lastly, receiver operator curve (ROC) analysis demonstrated unadjusted area under the curve (AUC) for uFABP3/Cr of 0.79, which improved to 0.86 after adjusting for eGFR, age, hypercholesteremia, smoking and diabetes. In conclusion, our results demonstrate a strong association between uFABP3/Cr and PAD and suggest the potential of uFABP3/Cr in identifying patients with PAD.Abdelrahman ZamzamMuzammil H. SyedJohn HarlockJohn EikelboomKrishna K. SinghRawand AbdinMohammad QaduraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abdelrahman Zamzam Muzammil H. Syed John Harlock John Eikelboom Krishna K. Singh Rawand Abdin Mohammad Qadura Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease
description	Abstract Plasma levels of fatty acid binding protein 3 (pFABP3) are elevated in patients with peripheral artery disease (PAD). Since the kidney filters FABP3 from circulation, we investigated whether urinary fatty acid binding protein 3 (uFABP3) is associated with PAD, and also explored its potential as a diagnostic biomarker for this disease state. A total of 130 patients were recruited from outpatient clinics at St. Michael’s Hospital, comprising of 65 patients with PAD and 65 patients without PAD (non-PAD). Levels of uFABP3 normalized for urine creatinine (uFABP3/uCr) were 1.7-folds higher in patients with PAD [median (IQR) 4.41 (2.79–8.08)] compared with non-PAD controls [median (IQR) 2.49 (1.78–3.12), p-value = 0.001]. Subgroup analysis demonstrated no significant effect of cardiovascular risk factors (age, sex, hypertension, hypercholesteremia, diabetes and smoking) on uFABP3/uCr in both PAD and non-PAD patients. Spearmen correlation studies demonstrated a significant negative correlation between uFABP3/uCr and ABI (ρ = − 0.436; p-value = 0.001). Regression analysis demonstrated that uFABP3/Cr levels were associated with PAD independently of age, sex, hypercholesterolemia, smoking, prior history of coronary arterial disease and Estimated Glomerular Filtration rate (eGFR) [odds ratio: 2.34 (95% confidence interval: 1.47–3.75) p-value < 0.001]. Lastly, receiver operator curve (ROC) analysis demonstrated unadjusted area under the curve (AUC) for uFABP3/Cr of 0.79, which improved to 0.86 after adjusting for eGFR, age, hypercholesteremia, smoking and diabetes. In conclusion, our results demonstrate a strong association between uFABP3/Cr and PAD and suggest the potential of uFABP3/Cr in identifying patients with PAD.
format	article
author	Abdelrahman Zamzam Muzammil H. Syed John Harlock John Eikelboom Krishna K. Singh Rawand Abdin Mohammad Qadura
author_facet	Abdelrahman Zamzam Muzammil H. Syed John Harlock John Eikelboom Krishna K. Singh Rawand Abdin Mohammad Qadura
author_sort	Abdelrahman Zamzam
title	Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease
title_short	Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease
title_full	Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease
title_fullStr	Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease
title_full_unstemmed	Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease
title_sort	urinary fatty acid binding protein 3 (ufabp3) is a potential biomarker for peripheral arterial disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ae211f7b4094becb723ab7f42cf61d3
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Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease

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