Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion

Abstract Intrauterine adhesion (IUA) is a common gynaecological disease that develops from infection or trauma. IUA disease may seriously affect the physical and mental health of women of childbearing age, which may lead to symptoms such as hypomenorrhea or infertility. Presently, hysteroscopic tran...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Junyan Ma, Hong Zhan, Wen Li, Liqi Zhang, Feng Yun, Ruijin Wu, Jun Lin, Yangyang Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Intrauterine adhesion Biomaterial Stem cell therapy 3D printing Electrospinning Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/8aea88516b3c488186a3460a0544142a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8aea88516b3c488186a3460a0544142a
record_format	dspace
spelling	oai:doaj.org-article:8aea88516b3c488186a3460a0544142a2021-11-28T12:06:12ZRecent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion10.1186/s40824-021-00242-62055-7124https://doaj.org/article/8aea88516b3c488186a3460a0544142a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40824-021-00242-6https://doaj.org/toc/2055-7124Abstract Intrauterine adhesion (IUA) is a common gynaecological disease that develops from infection or trauma. IUA disease may seriously affect the physical and mental health of women of childbearing age, which may lead to symptoms such as hypomenorrhea or infertility. Presently, hysteroscopic transcervical resection of adhesion (TCRA) is the principal therapy for IUAs, although its function in preventing the recurrence of adhesion and preserving fertility is limited. Pharmaceuticals such as hormones and vasoactive agents and the placement of nondegradable stents are the most common postoperative adjuvant therapy methods. However, the repair of injured endometrium is relatively restricted due to the different anatomical structures of the endometrium. Recently, the treatment outcome of IUAs has improved with the advancement of hysteroscopic techniques. In particular, the application of bioactive scaffolds combined with tissue engineering technology has proven to have high therapeutic potential or endometrial repair in IUA treatment. Herein, this review has summarized past therapeutic strategies, including postoperative adjuvant therapy, cell or therapeutic molecular delivery therapy methods and bioactive scaffold-based tissue engineering methods. Therefore, this review presented the recent therapeutic strategies for repairing endometrium treatment and pointed out the issues of clinical concern to provide alternative methods for the management of IUAs.Junyan MaHong ZhanWen LiLiqi ZhangFeng YunRuijin WuJun LinYangyang LiBMCarticleIntrauterine adhesionBiomaterialStem cell therapy3D printingElectrospinningMedical technologyR855-855.5ENBiomaterials Research, Vol 25, Iss 1, Pp 1-25 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intrauterine adhesion Biomaterial Stem cell therapy 3D printing Electrospinning Medical technology R855-855.5
spellingShingle	Intrauterine adhesion Biomaterial Stem cell therapy 3D printing Electrospinning Medical technology R855-855.5 Junyan Ma Hong Zhan Wen Li Liqi Zhang Feng Yun Ruijin Wu Jun Lin Yangyang Li Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion
description	Abstract Intrauterine adhesion (IUA) is a common gynaecological disease that develops from infection or trauma. IUA disease may seriously affect the physical and mental health of women of childbearing age, which may lead to symptoms such as hypomenorrhea or infertility. Presently, hysteroscopic transcervical resection of adhesion (TCRA) is the principal therapy for IUAs, although its function in preventing the recurrence of adhesion and preserving fertility is limited. Pharmaceuticals such as hormones and vasoactive agents and the placement of nondegradable stents are the most common postoperative adjuvant therapy methods. However, the repair of injured endometrium is relatively restricted due to the different anatomical structures of the endometrium. Recently, the treatment outcome of IUAs has improved with the advancement of hysteroscopic techniques. In particular, the application of bioactive scaffolds combined with tissue engineering technology has proven to have high therapeutic potential or endometrial repair in IUA treatment. Herein, this review has summarized past therapeutic strategies, including postoperative adjuvant therapy, cell or therapeutic molecular delivery therapy methods and bioactive scaffold-based tissue engineering methods. Therefore, this review presented the recent therapeutic strategies for repairing endometrium treatment and pointed out the issues of clinical concern to provide alternative methods for the management of IUAs.
format	article
author	Junyan Ma Hong Zhan Wen Li Liqi Zhang Feng Yun Ruijin Wu Jun Lin Yangyang Li
author_facet	Junyan Ma Hong Zhan Wen Li Liqi Zhang Feng Yun Ruijin Wu Jun Lin Yangyang Li
author_sort	Junyan Ma
title	Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion
title_short	Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion
title_full	Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion
title_fullStr	Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion
title_full_unstemmed	Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion
title_sort	recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8aea88516b3c488186a3460a0544142a
work_keys_str_mv	AT junyanma recenttrendsintherapeuticstrategiesforrepairingendometrialtissueinintrauterineadhesion AT hongzhan recenttrendsintherapeuticstrategiesforrepairingendometrialtissueinintrauterineadhesion AT wenli recenttrendsintherapeuticstrategiesforrepairingendometrialtissueinintrauterineadhesion AT liqizhang recenttrendsintherapeuticstrategiesforrepairingendometrialtissueinintrauterineadhesion AT fengyun recenttrendsintherapeuticstrategiesforrepairingendometrialtissueinintrauterineadhesion AT ruijinwu recenttrendsintherapeuticstrategiesforrepairingendometrialtissueinintrauterineadhesion AT junlin recenttrendsintherapeuticstrategiesforrepairingendometrialtissueinintrauterineadhesion AT yangyangli recenttrendsintherapeuticstrategiesforrepairingendometrialtissueinintrauterineadhesion
_version_	1718408210322292736

Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion

Ejemplares similares