Radiation inducible MafB gene is required for thymic regeneration

Abstract The thymus facilitates mature T cell production by providing a suitable stromal microenvironment. This microenvironment is impaired by radiation and aging which lead to immune system disturbances known as thymic involution. Young adult thymus shows thymic recovery after such involution. Alt...

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Autores principales:	Daiki Hashimoto, Jose Gabriel R. Colet, Aki Murashima, Kota Fujimoto, Yuko Ueda, Kentaro Suzuki, Taiju Hyuga, Hiroaki Hemmi, Tsuneyasu Kaisho, Satoru Takahashi, Yousuke Takahama, Gen Yamada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8af00c56932d4c45b9aec80fe2653355
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spelling	oai:doaj.org-article:8af00c56932d4c45b9aec80fe26533552021-12-02T14:58:45ZRadiation inducible MafB gene is required for thymic regeneration10.1038/s41598-021-89836-72045-2322https://doaj.org/article/8af00c56932d4c45b9aec80fe26533552021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89836-7https://doaj.org/toc/2045-2322Abstract The thymus facilitates mature T cell production by providing a suitable stromal microenvironment. This microenvironment is impaired by radiation and aging which lead to immune system disturbances known as thymic involution. Young adult thymus shows thymic recovery after such involution. Although various genes have been reported for thymocytes and thymic epithelial cells in such processes, the roles of stromal transcription factors in these remain incompletely understood. MafB (v-maf musculoaponeurotic fibrosarcoma oncogene homolog B) is a transcription factor expressed in thymic stroma and its expression was induced a day after radiation exposure. Hence, the roles of mesenchymal MafB in the process of thymic regeneration offers an intriguing research topic also for radiation biology. The current study investigated whether MafB plays roles in the adult thymus. MafB/green fluorescent protein knock-in mutant (MafB +/GFP) mice showed impaired thymic regeneration after the sublethal irradiation, judged by reduced thymus size, total thymocyte number and medullary complexity. Furthermore, IL4 was induced after irradiation and such induction was reduced in mutant mice. The mutants also displayed signs of accelerated age-related thymic involution. Altogether, these results suggest possible functions of MafB in the processes of thymic recovery after irradiation, and maintenance during aging.Daiki HashimotoJose Gabriel R. ColetAki MurashimaKota FujimotoYuko UedaKentaro SuzukiTaiju HyugaHiroaki HemmiTsuneyasu KaishoSatoru TakahashiYousuke TakahamaGen YamadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daiki Hashimoto Jose Gabriel R. Colet Aki Murashima Kota Fujimoto Yuko Ueda Kentaro Suzuki Taiju Hyuga Hiroaki Hemmi Tsuneyasu Kaisho Satoru Takahashi Yousuke Takahama Gen Yamada Radiation inducible MafB gene is required for thymic regeneration
description	Abstract The thymus facilitates mature T cell production by providing a suitable stromal microenvironment. This microenvironment is impaired by radiation and aging which lead to immune system disturbances known as thymic involution. Young adult thymus shows thymic recovery after such involution. Although various genes have been reported for thymocytes and thymic epithelial cells in such processes, the roles of stromal transcription factors in these remain incompletely understood. MafB (v-maf musculoaponeurotic fibrosarcoma oncogene homolog B) is a transcription factor expressed in thymic stroma and its expression was induced a day after radiation exposure. Hence, the roles of mesenchymal MafB in the process of thymic regeneration offers an intriguing research topic also for radiation biology. The current study investigated whether MafB plays roles in the adult thymus. MafB/green fluorescent protein knock-in mutant (MafB +/GFP) mice showed impaired thymic regeneration after the sublethal irradiation, judged by reduced thymus size, total thymocyte number and medullary complexity. Furthermore, IL4 was induced after irradiation and such induction was reduced in mutant mice. The mutants also displayed signs of accelerated age-related thymic involution. Altogether, these results suggest possible functions of MafB in the processes of thymic recovery after irradiation, and maintenance during aging.
format	article
author	Daiki Hashimoto Jose Gabriel R. Colet Aki Murashima Kota Fujimoto Yuko Ueda Kentaro Suzuki Taiju Hyuga Hiroaki Hemmi Tsuneyasu Kaisho Satoru Takahashi Yousuke Takahama Gen Yamada
author_facet	Daiki Hashimoto Jose Gabriel R. Colet Aki Murashima Kota Fujimoto Yuko Ueda Kentaro Suzuki Taiju Hyuga Hiroaki Hemmi Tsuneyasu Kaisho Satoru Takahashi Yousuke Takahama Gen Yamada
author_sort	Daiki Hashimoto
title	Radiation inducible MafB gene is required for thymic regeneration
title_short	Radiation inducible MafB gene is required for thymic regeneration
title_full	Radiation inducible MafB gene is required for thymic regeneration
title_fullStr	Radiation inducible MafB gene is required for thymic regeneration
title_full_unstemmed	Radiation inducible MafB gene is required for thymic regeneration
title_sort	radiation inducible mafb gene is required for thymic regeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8af00c56932d4c45b9aec80fe2653355
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Radiation inducible MafB gene is required for thymic regeneration

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