Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy

Peiqi Zhao, Lihua Qiu, Shiyong Zhou, Lanfang Li, Zhengzi Qian, Huilai Zhang Department of Lymphoma, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhao P, Qiu L, Zhou S, Li L, Qian Z, Zhang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	anti-pd-1 cancer cell membrane cancer immunotherapy melanoma mesoporous silica nanoparticle Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8af0459f15b74e4e896d63ecec09a3ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8af0459f15b74e4e896d63ecec09a3ab
record_format	dspace
spelling	oai:doaj.org-article:8af0459f15b74e4e896d63ecec09a3ab2021-12-02T13:28:23ZCancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy1178-2013https://doaj.org/article/8af0459f15b74e4e896d63ecec09a3ab2021-03-01T00:00:00Zhttps://www.dovepress.com/cancer-cell-membrane-camouflaged-mesoporous-silica-nanoparticles-combi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Peiqi Zhao, Lihua Qiu, Shiyong Zhou, Lanfang Li, Zhengzi Qian, Huilai Zhang Department of Lymphoma, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, 300060, People’s Republic of ChinaCorrespondence: Huilai ZhangDepartment of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, 24 Huanhu West Road, Hexi District, Tianjin, 300060, People’s Republic of ChinaTel +86-22-23340123Email zhlwgq@126.comPurpose: Although anti-programmed cell death protein 1 antibody (aPD1) immunotherapy and chemotherapy has made much progress in the treatment of melanoma, the efficacy still needs to be further improved.Methods: Cancer treatment has been greatly enhanced by the use of nanotechnology. Cancer cell membrane (CCM)-camouflaged nanoparticles have shown promising potential in tumor therapy due to their excellent homologous-targeting ability, long blood circulation and immune escape. This work presents a biocompatible and tumor acidic environmental responsive CCM-camouflaged mesoporous silica nanoparticle (CMSN) that is loaded with dacarbazine (DTIC) and combined with aPD1 to achieve better antitumor efficacy.Results: In vitro cell experiments demonstrated that DTIC@CMSN exhibits a better anti-tumor killing efficiency and a stronger ability to promote the apoptosis of tumor cells than free DTIC. In vivo antitumor results demonstrated that combination therapy of DTIC@CMSN chemotherapy and aPD1 immunotherapy remarkably suppress the melanoma growth and prolong survival time due to highly selective tumor killing, activation of tumor-specific T cells, and regulation of the immunosuppressive tumor microenvironment. In addition, safety evaluation studies of DTIC@CMSN also demonstrate their increased tumor accumulation and decreased systemic toxicity.Conclusion: This study provides a promising nano-platform for the combination of chemotherapy with immunotherapy, which is potentially useful for the treatment of melanoma.Keywords: anti-PD-1, cancer cell membrane, cancer immunotherapy, melanoma, mesoporous silica nanoparticleZhao PQiu LZhou SLi LQian ZZhang HDove Medical Pressarticleanti-pd-1cancer cell membranecancer immunotherapymelanomamesoporous silica nanoparticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2107-2121 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-pd-1 cancer cell membrane cancer immunotherapy melanoma mesoporous silica nanoparticle Medicine (General) R5-920
spellingShingle	anti-pd-1 cancer cell membrane cancer immunotherapy melanoma mesoporous silica nanoparticle Medicine (General) R5-920 Zhao P Qiu L Zhou S Li L Qian Z Zhang H Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy
description	Peiqi Zhao, Lihua Qiu, Shiyong Zhou, Lanfang Li, Zhengzi Qian, Huilai Zhang Department of Lymphoma, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, 300060, People’s Republic of ChinaCorrespondence: Huilai ZhangDepartment of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, 24 Huanhu West Road, Hexi District, Tianjin, 300060, People’s Republic of ChinaTel +86-22-23340123Email zhlwgq@126.comPurpose: Although anti-programmed cell death protein 1 antibody (aPD1) immunotherapy and chemotherapy has made much progress in the treatment of melanoma, the efficacy still needs to be further improved.Methods: Cancer treatment has been greatly enhanced by the use of nanotechnology. Cancer cell membrane (CCM)-camouflaged nanoparticles have shown promising potential in tumor therapy due to their excellent homologous-targeting ability, long blood circulation and immune escape. This work presents a biocompatible and tumor acidic environmental responsive CCM-camouflaged mesoporous silica nanoparticle (CMSN) that is loaded with dacarbazine (DTIC) and combined with aPD1 to achieve better antitumor efficacy.Results: In vitro cell experiments demonstrated that DTIC@CMSN exhibits a better anti-tumor killing efficiency and a stronger ability to promote the apoptosis of tumor cells than free DTIC. In vivo antitumor results demonstrated that combination therapy of DTIC@CMSN chemotherapy and aPD1 immunotherapy remarkably suppress the melanoma growth and prolong survival time due to highly selective tumor killing, activation of tumor-specific T cells, and regulation of the immunosuppressive tumor microenvironment. In addition, safety evaluation studies of DTIC@CMSN also demonstrate their increased tumor accumulation and decreased systemic toxicity.Conclusion: This study provides a promising nano-platform for the combination of chemotherapy with immunotherapy, which is potentially useful for the treatment of melanoma.Keywords: anti-PD-1, cancer cell membrane, cancer immunotherapy, melanoma, mesoporous silica nanoparticle
format	article
author	Zhao P Qiu L Zhou S Li L Qian Z Zhang H
author_facet	Zhao P Qiu L Zhou S Li L Qian Z Zhang H
author_sort	Zhao P
title	Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy
title_short	Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy
title_full	Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy
title_fullStr	Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy
title_full_unstemmed	Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy
title_sort	cancer cell membrane camouflaged mesoporous silica nanoparticles combined with immune checkpoint blockade for regulating tumor microenvironment and enhancing antitumor therapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8af0459f15b74e4e896d63ecec09a3ab
work_keys_str_mv	AT zhaop cancercellmembranecamouflagedmesoporoussilicananoparticlescombinedwithimmunecheckpointblockadeforregulatingtumormicroenvironmentandenhancingantitumortherapy AT qiul cancercellmembranecamouflagedmesoporoussilicananoparticlescombinedwithimmunecheckpointblockadeforregulatingtumormicroenvironmentandenhancingantitumortherapy AT zhous cancercellmembranecamouflagedmesoporoussilicananoparticlescombinedwithimmunecheckpointblockadeforregulatingtumormicroenvironmentandenhancingantitumortherapy AT lil cancercellmembranecamouflagedmesoporoussilicananoparticlescombinedwithimmunecheckpointblockadeforregulatingtumormicroenvironmentandenhancingantitumortherapy AT qianz cancercellmembranecamouflagedmesoporoussilicananoparticlescombinedwithimmunecheckpointblockadeforregulatingtumormicroenvironmentandenhancingantitumortherapy AT zhangh cancercellmembranecamouflagedmesoporoussilicananoparticlescombinedwithimmunecheckpointblockadeforregulatingtumormicroenvironmentandenhancingantitumortherapy
_version_	1718392987250065408

Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy

Ejemplares similares