Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis

Breast cancer metastatic progression to critical secondary sites is the second leading cause of cancer-related mortality in women. While existing therapies are highly effective in combating primary tumors, metastatic disease is generally deemed incurable with a median survival of only 2, 3 years. Ex...

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Autores principales:	Dara Brena, Ming-Bo Huang, Vincent Bond
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Metastatic breast cancer Extracellular vesicle Tumor microenvironment Pre-metastatic niche Precision medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8af156e49ea04ffb8c31f27bca39bbac
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spelling	oai:doaj.org-article:8af156e49ea04ffb8c31f27bca39bbac2021-11-28T04:29:53ZExtracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis1936-523310.1016/j.tranon.2021.101286https://doaj.org/article/8af156e49ea04ffb8c31f27bca39bbac2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1936523321002771https://doaj.org/toc/1936-5233Breast cancer metastatic progression to critical secondary sites is the second leading cause of cancer-related mortality in women. While existing therapies are highly effective in combating primary tumors, metastatic disease is generally deemed incurable with a median survival of only 2, 3 years. Extensive efforts have focused on identifying metastatic contributory targets for therapeutic antagonism and prevention to improve patient survivability. Excessive breast cancer release of extracellular vesicles (EVs), whose contents stimulate a metastatic phenotype, represents a promising target. Complex breast cancer intercellular communication networks are based on EV transport and transference of molecular information is in bulk resulting in complete reprogramming events within recipient cells. Other breast cancer cells can acquire aggressive phenotypes, endothelial cells can be induced to undergo tubule formation, and immune cells can be neutralized. Recent advancements continue to implicate the critical role EVs play in cultivating a tumor microenvironment tailored to cancer proliferation, metastasis, immune evasion, and conference of drug resistance. This literature review serves to frame the role of EV transport in breast cancer progression and metastasis. The following five sections will be addressed: (1) Intercellular communication in developing a tumor microenvironment & pre-metastatic niche. (2) Induction of the epithelial-to-mesenchymal transition (EMT). (3). Immune suppression & evasion. (4) Transmission of drug resistance mechanisms. (5) Precision medicine: clinical applications of EVs.Dara BrenaMing-Bo HuangVincent BondElsevierarticleMetastatic breast cancerExtracellular vesicleTumor microenvironmentPre-metastatic nichePrecision medicineNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTranslational Oncology, Vol 15, Iss 1, Pp 101286- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metastatic breast cancer Extracellular vesicle Tumor microenvironment Pre-metastatic niche Precision medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Metastatic breast cancer Extracellular vesicle Tumor microenvironment Pre-metastatic niche Precision medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Dara Brena Ming-Bo Huang Vincent Bond Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis
description	Breast cancer metastatic progression to critical secondary sites is the second leading cause of cancer-related mortality in women. While existing therapies are highly effective in combating primary tumors, metastatic disease is generally deemed incurable with a median survival of only 2, 3 years. Extensive efforts have focused on identifying metastatic contributory targets for therapeutic antagonism and prevention to improve patient survivability. Excessive breast cancer release of extracellular vesicles (EVs), whose contents stimulate a metastatic phenotype, represents a promising target. Complex breast cancer intercellular communication networks are based on EV transport and transference of molecular information is in bulk resulting in complete reprogramming events within recipient cells. Other breast cancer cells can acquire aggressive phenotypes, endothelial cells can be induced to undergo tubule formation, and immune cells can be neutralized. Recent advancements continue to implicate the critical role EVs play in cultivating a tumor microenvironment tailored to cancer proliferation, metastasis, immune evasion, and conference of drug resistance. This literature review serves to frame the role of EV transport in breast cancer progression and metastasis. The following five sections will be addressed: (1) Intercellular communication in developing a tumor microenvironment & pre-metastatic niche. (2) Induction of the epithelial-to-mesenchymal transition (EMT). (3). Immune suppression & evasion. (4) Transmission of drug resistance mechanisms. (5) Precision medicine: clinical applications of EVs.
format	article
author	Dara Brena Ming-Bo Huang Vincent Bond
author_facet	Dara Brena Ming-Bo Huang Vincent Bond
author_sort	Dara Brena
title	Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis
title_short	Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis
title_full	Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis
title_fullStr	Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis
title_full_unstemmed	Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis
title_sort	extracellular vesicle-mediated transport: reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/8af156e49ea04ffb8c31f27bca39bbac
work_keys_str_mv	AT darabrena extracellularvesiclemediatedtransportreprogrammingatumormicroenvironmentconducivewithbreastcancerprogressionandmetastasis AT mingbohuang extracellularvesiclemediatedtransportreprogrammingatumormicroenvironmentconducivewithbreastcancerprogressionandmetastasis AT vincentbond extracellularvesiclemediatedtransportreprogrammingatumormicroenvironmentconducivewithbreastcancerprogressionandmetastasis
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Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis

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