Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.

<h4>Background</h4>Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) is useful to diagnose peripheral lung lesions. The data of tumor cell...

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Autores principales:	Naoko Katsurada, Motoko Tachihara, Naoe Jimbo, Masatsugu Yamamoto, Junya Yoshioka, Chihiro Mimura, Hiroki Satoh, Koichi Furukawa, Takehiro Otoshi, Tatsunori Kiriu, Yuichiro Yasuda, Tomonori Tanaka, Tatsuya Nagano, Yoshihiro Nishimura
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8af1634a100f4b40a5ede7f4623c3e1d
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spelling	oai:doaj.org-article:8af1634a100f4b40a5ede7f4623c3e1d2021-12-02T20:13:19ZYield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.1932-620310.1371/journal.pone.0259236https://doaj.org/article/8af1634a100f4b40a5ede7f4623c3e1d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259236https://doaj.org/toc/1932-6203<h4>Background</h4>Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) is useful to diagnose peripheral lung lesions. The data of tumor cell numbers obtained by two different sizes of GSs is limited. We conducted this study to investigate the utility of a large GS kit to obtain many tumor cells in patients with NSCLC.<h4>Methods</h4>Patients with a peripheral lung lesion and suspected of NSCLC were prospectively enrolled. They underwent TBB with a 5.9-mm diameter bronchoscope with a large GS. When the lesion was invisible in EBUS, we changed to a thinner bronchoscope and TBB was performed with a small GS. We compared the tumor cell number prospectively obtained with a large GS (prospective large GS group) and those previously obtained with a small GS (small GS cohort). The primary endpoint was the tumor cell number per sample, and we assessed characteristics of lesions that could be obtained by TBB with large GS.<h4>Results</h4>Biopsy with large GS was performed in 55 of 87 patients (63.2%), and 37 were diagnosed with NSCLC based on histological samples. The number of tumor cells per sample was not different between two groups (658±553 vs. 532±526, estimated difference between two groups with 95% confidence interval (CI); 125 (-125-376), p = 0.32). The sample size of the large GS group was significantly larger than that of the small GS cohort (1.75 mm2 vs. 0.83 mm2, estimated difference with 95% CI; 0.92 (0.60-1.23) mm2, p = 0.00000019). The lesion involving a third or less bronchus generation was predictive factors using large GS.<h4>Conclusions</h4>The sample size obtained with large GS was significantly larger compared to that obtained with small GS, but there was no significant difference in tumor cell number. The 5.9-mm diameter bronchoscope with large GS can be used for lesions involving a third or less bronchus generation.Naoko KatsuradaMotoko TachiharaNaoe JimboMasatsugu YamamotoJunya YoshiokaChihiro MimuraHiroki SatohKoichi FurukawaTakehiro OtoshiTatsunori KiriuYuichiro YasudaTomonori TanakaTatsuya NaganoYoshihiro NishimuraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0259236 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naoko Katsurada Motoko Tachihara Naoe Jimbo Masatsugu Yamamoto Junya Yoshioka Chihiro Mimura Hiroki Satoh Koichi Furukawa Takehiro Otoshi Tatsunori Kiriu Yuichiro Yasuda Tomonori Tanaka Tatsuya Nagano Yoshihiro Nishimura Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.
description	<h4>Background</h4>Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) is useful to diagnose peripheral lung lesions. The data of tumor cell numbers obtained by two different sizes of GSs is limited. We conducted this study to investigate the utility of a large GS kit to obtain many tumor cells in patients with NSCLC.<h4>Methods</h4>Patients with a peripheral lung lesion and suspected of NSCLC were prospectively enrolled. They underwent TBB with a 5.9-mm diameter bronchoscope with a large GS. When the lesion was invisible in EBUS, we changed to a thinner bronchoscope and TBB was performed with a small GS. We compared the tumor cell number prospectively obtained with a large GS (prospective large GS group) and those previously obtained with a small GS (small GS cohort). The primary endpoint was the tumor cell number per sample, and we assessed characteristics of lesions that could be obtained by TBB with large GS.<h4>Results</h4>Biopsy with large GS was performed in 55 of 87 patients (63.2%), and 37 were diagnosed with NSCLC based on histological samples. The number of tumor cells per sample was not different between two groups (658±553 vs. 532±526, estimated difference between two groups with 95% confidence interval (CI); 125 (-125-376), p = 0.32). The sample size of the large GS group was significantly larger than that of the small GS cohort (1.75 mm2 vs. 0.83 mm2, estimated difference with 95% CI; 0.92 (0.60-1.23) mm2, p = 0.00000019). The lesion involving a third or less bronchus generation was predictive factors using large GS.<h4>Conclusions</h4>The sample size obtained with large GS was significantly larger compared to that obtained with small GS, but there was no significant difference in tumor cell number. The 5.9-mm diameter bronchoscope with large GS can be used for lesions involving a third or less bronchus generation.
format	article
author	Naoko Katsurada Motoko Tachihara Naoe Jimbo Masatsugu Yamamoto Junya Yoshioka Chihiro Mimura Hiroki Satoh Koichi Furukawa Takehiro Otoshi Tatsunori Kiriu Yuichiro Yasuda Tomonori Tanaka Tatsuya Nagano Yoshihiro Nishimura
author_facet	Naoko Katsurada Motoko Tachihara Naoe Jimbo Masatsugu Yamamoto Junya Yoshioka Chihiro Mimura Hiroki Satoh Koichi Furukawa Takehiro Otoshi Tatsunori Kiriu Yuichiro Yasuda Tomonori Tanaka Tatsuya Nagano Yoshihiro Nishimura
author_sort	Naoko Katsurada
title	Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.
title_short	Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.
title_full	Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.
title_fullStr	Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.
title_full_unstemmed	Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.
title_sort	yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: a prospective study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8af1634a100f4b40a5ede7f4623c3e1d
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Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study.

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