Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture

Chun-Jui Weng,1,2 Demei Lee,2 Jui Ho,2 Shih-Jung Liu1,2 1Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan; 2Department of Mechanical Engineering, Chang Gung University, Taoyuan, TaiwanCorrespondence: Shih-Jung LiuBiomaterials Lab...

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Autores principales:	Weng CJ, Lee D, Ho J, Liu SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	doxycycline tendon nanofibrous membrane Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8af1bd25a05a42a1967a0f37c80bd755
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spelling	oai:doaj.org-article:8af1bd25a05a42a1967a0f37c80bd7552021-12-02T04:41:28ZDoxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture1178-2013https://doaj.org/article/8af1bd25a05a42a1967a0f37c80bd7552020-01-01T00:00:00Zhttps://www.dovepress.com/doxycycline-embedded-nanofibrous-membranes-help-promote-healing-of-ten-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chun-Jui Weng,1,2 Demei Lee,2 Jui Ho,2 Shih-Jung Liu1,2 1Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan; 2Department of Mechanical Engineering, Chang Gung University, Taoyuan, TaiwanCorrespondence: Shih-Jung LiuBiomaterials Lab, Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, TaiwanTel +886-3-2118166Fax +886-3-2118558Email profsjliu5347@gmail.comBackground: Despite recent advancements in surgical techniques, the repair of tendon rupture remains a challenge for surgeons. The purpose of this study was to develop novel doxycycline-loaded biodegradable nanofibrous membranes and evaluate their efficacy for the repair of Achilles tendon rupture in a rat model.Materials and Methods: The drug-loaded nanofibers were prepared using the electrospinning process and drug release from the prepared membranes was investigated both in vitro and in vivo. Furthermore, the safety and efficacy of the drug-loaded nanofibrous membranes were evaluated in rats that underwent tendon surgeries. An animal behavior cage was employed to monitor the post-surgery activity of the animals.Results: The experimental results demonstrated that poly(D,L-lactide-co-glycolide) (PLGA) nanofibers released effective concentrations of doxycycline for more than 40 days post-surgery, and the systemic plasma drug concentration was low. Rats receiving implantation of doxycycline-loaded nanofibers also showed greater activities and stronger tendons post-operation.Conclusion: Nanofibers loaded with doxycycline may have great potential in the repair of Achilles tendon rupture.Keywords: doxycycline, tendon, nanofibrous membraneWeng CJLee DHo JLiu SJDove Medical Pressarticledoxycyclinetendonnanofibrous membraneMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 125-136 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	doxycycline tendon nanofibrous membrane Medicine (General) R5-920
spellingShingle	doxycycline tendon nanofibrous membrane Medicine (General) R5-920 Weng CJ Lee D Ho J Liu SJ Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture
description	Chun-Jui Weng,1,2 Demei Lee,2 Jui Ho,2 Shih-Jung Liu1,2 1Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan; 2Department of Mechanical Engineering, Chang Gung University, Taoyuan, TaiwanCorrespondence: Shih-Jung LiuBiomaterials Lab, Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, TaiwanTel +886-3-2118166Fax +886-3-2118558Email profsjliu5347@gmail.comBackground: Despite recent advancements in surgical techniques, the repair of tendon rupture remains a challenge for surgeons. The purpose of this study was to develop novel doxycycline-loaded biodegradable nanofibrous membranes and evaluate their efficacy for the repair of Achilles tendon rupture in a rat model.Materials and Methods: The drug-loaded nanofibers were prepared using the electrospinning process and drug release from the prepared membranes was investigated both in vitro and in vivo. Furthermore, the safety and efficacy of the drug-loaded nanofibrous membranes were evaluated in rats that underwent tendon surgeries. An animal behavior cage was employed to monitor the post-surgery activity of the animals.Results: The experimental results demonstrated that poly(D,L-lactide-co-glycolide) (PLGA) nanofibers released effective concentrations of doxycycline for more than 40 days post-surgery, and the systemic plasma drug concentration was low. Rats receiving implantation of doxycycline-loaded nanofibers also showed greater activities and stronger tendons post-operation.Conclusion: Nanofibers loaded with doxycycline may have great potential in the repair of Achilles tendon rupture.Keywords: doxycycline, tendon, nanofibrous membrane
format	article
author	Weng CJ Lee D Ho J Liu SJ
author_facet	Weng CJ Lee D Ho J Liu SJ
author_sort	Weng CJ
title	Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture
title_short	Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture
title_full	Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture
title_fullStr	Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture
title_full_unstemmed	Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture
title_sort	doxycycline-embedded nanofibrous membranes help promote healing of tendon rupture
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/8af1bd25a05a42a1967a0f37c80bd755
work_keys_str_mv	AT wengcj doxycyclineembeddednanofibrousmembraneshelppromotehealingoftendonrupture AT leed doxycyclineembeddednanofibrousmembraneshelppromotehealingoftendonrupture AT hoj doxycyclineembeddednanofibrousmembraneshelppromotehealingoftendonrupture AT liusj doxycyclineembeddednanofibrousmembraneshelppromotehealingoftendonrupture
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Doxycycline-Embedded Nanofibrous Membranes Help Promote Healing of Tendon Rupture

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