Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study

Abstract Higher cortisol levels due to a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). Increased cortisol levels change both the brain morphology and function in MDD patients. The multivariate source-based morphometry (SBM) techn...

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Autores principales:	LeHoa Nguyen, Shingo Kakeda, Keita Watanabe, Asuka Katsuki, Koichiro Sugimoto, Natsuki Igata, Takahiro Shinkai, Osamu Abe, Yukunori Korogi, Atsuko Ikenouchi, Reiji Yoshimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8af2624420b54979aa1e3819b0e86dce
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spelling	oai:doaj.org-article:8af2624420b54979aa1e3819b0e86dce2021-12-02T11:57:58ZBrain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study10.1038/s41598-020-79220-22045-2322https://doaj.org/article/8af2624420b54979aa1e3819b0e86dce2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79220-2https://doaj.org/toc/2045-2322Abstract Higher cortisol levels due to a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). Increased cortisol levels change both the brain morphology and function in MDD patients. The multivariate source-based morphometry (SBM) technique has been applied to investigate neuroanatomical changes in some neuropsychiatric diseases, but not MDD. We aimed to examine the alterations in gray matter (GM) networks and their relationship with serum cortisol levels in first-episode, drug-naïve MDD patients using SBM. Forty-two patients with MDD and 39 controls were recruited via interviews. Morning serum cortisol levels were measured, and high-resolution T1-weighted imaging followed by SBM analysis was performed in all participants. The patients had significantly higher serum cortisol levels than the controls. We found two GM sources, which were significantly different between patients with MDD and controls (prefrontal network, p < .01; insula-temporal network, p < .01). Serum cortisol levels showed a statistically significant negative correlation with the loading coefficients of the prefrontal network (r = − 0.354, p = 0.02). In conclusion, increased serum cortisol levels were associated with reductions in the prefrontal network in the early stage of MDD, and SBM may be a useful approach for analyzing structural MRI data.LeHoa NguyenShingo KakedaKeita WatanabeAsuka KatsukiKoichiro SugimotoNatsuki IgataTakahiro ShinkaiOsamu AbeYukunori KorogiAtsuko IkenouchiReiji YoshimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q LeHoa Nguyen Shingo Kakeda Keita Watanabe Asuka Katsuki Koichiro Sugimoto Natsuki Igata Takahiro Shinkai Osamu Abe Yukunori Korogi Atsuko Ikenouchi Reiji Yoshimura Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study
description	Abstract Higher cortisol levels due to a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). Increased cortisol levels change both the brain morphology and function in MDD patients. The multivariate source-based morphometry (SBM) technique has been applied to investigate neuroanatomical changes in some neuropsychiatric diseases, but not MDD. We aimed to examine the alterations in gray matter (GM) networks and their relationship with serum cortisol levels in first-episode, drug-naïve MDD patients using SBM. Forty-two patients with MDD and 39 controls were recruited via interviews. Morning serum cortisol levels were measured, and high-resolution T1-weighted imaging followed by SBM analysis was performed in all participants. The patients had significantly higher serum cortisol levels than the controls. We found two GM sources, which were significantly different between patients with MDD and controls (prefrontal network, p < .01; insula-temporal network, p < .01). Serum cortisol levels showed a statistically significant negative correlation with the loading coefficients of the prefrontal network (r = − 0.354, p = 0.02). In conclusion, increased serum cortisol levels were associated with reductions in the prefrontal network in the early stage of MDD, and SBM may be a useful approach for analyzing structural MRI data.
format	article
author	LeHoa Nguyen Shingo Kakeda Keita Watanabe Asuka Katsuki Koichiro Sugimoto Natsuki Igata Takahiro Shinkai Osamu Abe Yukunori Korogi Atsuko Ikenouchi Reiji Yoshimura
author_facet	LeHoa Nguyen Shingo Kakeda Keita Watanabe Asuka Katsuki Koichiro Sugimoto Natsuki Igata Takahiro Shinkai Osamu Abe Yukunori Korogi Atsuko Ikenouchi Reiji Yoshimura
author_sort	LeHoa Nguyen
title	Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study
title_short	Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study
title_full	Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study
title_fullStr	Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study
title_full_unstemmed	Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study
title_sort	brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8af2624420b54979aa1e3819b0e86dce
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Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study

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