CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS

Abstract. We have observed eighty-nine patients with chronic recurrent infections of upper respiratory tract. Multiple immune parameters were evaluated during remissions of the disease. Increase in relative and absolute CD3+CD4+CD25+, CD3+HLA-DR+, CD3+CD16/CD56+ counts of blood lymphocytes, as well...

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Autores principales:	I. A. Novikova, T. S. Petrenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immune profiling recurrent upper respiratory tract infection Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8af4ef35534d40ee91787c062ffd555f
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spelling	oai:doaj.org-article:8af4ef35534d40ee91787c062ffd555f2021-11-18T08:03:40ZCLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS1563-06252313-741X10.15789/1563-0625-2012-4-5-423-428https://doaj.org/article/8af4ef35534d40ee91787c062ffd555f2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/377https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have observed eighty-nine patients with chronic recurrent infections of upper respiratory tract. Multiple immune parameters were evaluated during remissions of the disease. Increase in relative and absolute CD3+CD4+CD25+, CD3+HLA-DR+, CD3+CD16/CD56+ counts of blood lymphocytes, as well as higher concentrations of circulating immune complexes (CIC), along with decreased serum IgM and IgG levels were observed among the patients, as compared with appropriate parameters of control group. However, the major lymphocyte subsets did not differ between patients and controls. Hence, a content of CD3+CD16/CD56+ lymphocytes proved to be the most informative immunological parameter in the patients, since their levels directly correlate with duration of the disease and exacerbation rates. Meanwhile, CD3+СD16/СD56+cell counts show a negative correlation with the total numbers of B-lymphocytes and IgM concentrations in peripheral blood.I. A. NovikovaT. S. PetrenkoSPb RAACIarticleimmune profilingrecurrent upper respiratory tract infectionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 423-428 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune profiling recurrent upper respiratory tract infection Immunologic diseases. Allergy RC581-607
spellingShingle	immune profiling recurrent upper respiratory tract infection Immunologic diseases. Allergy RC581-607 I. A. Novikova T. S. Petrenko CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS
description	Abstract. We have observed eighty-nine patients with chronic recurrent infections of upper respiratory tract. Multiple immune parameters were evaluated during remissions of the disease. Increase in relative and absolute CD3+CD4+CD25+, CD3+HLA-DR+, CD3+CD16/CD56+ counts of blood lymphocytes, as well as higher concentrations of circulating immune complexes (CIC), along with decreased serum IgM and IgG levels were observed among the patients, as compared with appropriate parameters of control group. However, the major lymphocyte subsets did not differ between patients and controls. Hence, a content of CD3+CD16/CD56+ lymphocytes proved to be the most informative immunological parameter in the patients, since their levels directly correlate with duration of the disease and exacerbation rates. Meanwhile, CD3+СD16/СD56+cell counts show a negative correlation with the total numbers of B-lymphocytes and IgM concentrations in peripheral blood.
format	article
author	I. A. Novikova T. S. Petrenko
author_facet	I. A. Novikova T. S. Petrenko
author_sort	I. A. Novikova
title	CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS
title_short	CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS
title_full	CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS
title_fullStr	CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS
title_full_unstemmed	CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS
title_sort	clinical value of immune profiling in patients with recurrent upper respiratory tract infections
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8af4ef35534d40ee91787c062ffd555f
work_keys_str_mv	AT ianovikova clinicalvalueofimmuneprofilinginpatientswithrecurrentupperrespiratorytractinfections AT tspetrenko clinicalvalueofimmuneprofilinginpatientswithrecurrentupperrespiratorytractinfections
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CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS

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