Bi-directional cell-pericellular matrix interactions direct stem cell fate

Bi-directional cell-pericellular matrix interactions direct stem cell fate

3D hydrogels have provided information on the physical requirements of stem cell fate, but the contribution of interactions with the pericellular environment are under-explored. Here the authors show that pericellular matrix secreted by human bone marrow stromal cells (hMSC) embedded in a HA-based h...

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Autores principales: Silvia A. Ferreira, Meghna S. Motwani, Peter A. Faull, Alexis J. Seymour, Tracy T. L. Yu, Marjan Enayati, Dheraj K. Taheem, Christoph Salzlechner, Tabasom Haghighi, Ewa M. Kania, Oommen P. Oommen, Tarek Ahmed, Sandra Loaiza, Katarzyna Parzych, Francesco Dazzi, Oommen P. Varghese, Frederic Festy, Agamemnon E. Grigoriadis, Holger W. Auner, Ambrosius P. Snijders, Laurent Bozec, Eileen Gentleman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/8af8d8a81ddc405d9f52c6d4512ee247
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spelling oai:doaj.org-article:8af8d8a81ddc405d9f52c6d4512ee2472021-12-02T16:56:40ZBi-directional cell-pericellular matrix interactions direct stem cell fate10.1038/s41467-018-06183-42041-1723https://doaj.org/article/8af8d8a81ddc405d9f52c6d4512ee2472018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06183-4https://doaj.org/toc/2041-17233D hydrogels have provided information on the physical requirements of stem cell fate, but the contribution of interactions with the pericellular environment are under-explored. Here the authors show that pericellular matrix secreted by human bone marrow stromal cells (hMSC) embedded in a HA-based hydrogel contribute to hMSC fate.Silvia A. FerreiraMeghna S. MotwaniPeter A. FaullAlexis J. SeymourTracy T. L. YuMarjan EnayatiDheraj K. TaheemChristoph SalzlechnerTabasom HaghighiEwa M. KaniaOommen P. OommenTarek AhmedSandra LoaizaKatarzyna ParzychFrancesco DazziOommen P. VargheseFrederic FestyAgamemnon E. GrigoriadisHolger W. AunerAmbrosius P. SnijdersLaurent BozecEileen GentlemanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Silvia A. Ferreira
Meghna S. Motwani
Peter A. Faull
Alexis J. Seymour
Tracy T. L. Yu
Marjan Enayati
Dheraj K. Taheem
Christoph Salzlechner
Tabasom Haghighi
Ewa M. Kania
Oommen P. Oommen
Tarek Ahmed
Sandra Loaiza
Katarzyna Parzych
Francesco Dazzi
Oommen P. Varghese
Frederic Festy
Agamemnon E. Grigoriadis
Holger W. Auner
Ambrosius P. Snijders
Laurent Bozec
Eileen Gentleman
Bi-directional cell-pericellular matrix interactions direct stem cell fate
description 3D hydrogels have provided information on the physical requirements of stem cell fate, but the contribution of interactions with the pericellular environment are under-explored. Here the authors show that pericellular matrix secreted by human bone marrow stromal cells (hMSC) embedded in a HA-based hydrogel contribute to hMSC fate.
format article
author Silvia A. Ferreira
Meghna S. Motwani
Peter A. Faull
Alexis J. Seymour
Tracy T. L. Yu
Marjan Enayati
Dheraj K. Taheem
Christoph Salzlechner
Tabasom Haghighi
Ewa M. Kania
Oommen P. Oommen
Tarek Ahmed
Sandra Loaiza
Katarzyna Parzych
Francesco Dazzi
Oommen P. Varghese
Frederic Festy
Agamemnon E. Grigoriadis
Holger W. Auner
Ambrosius P. Snijders
Laurent Bozec
Eileen Gentleman
author_facet Silvia A. Ferreira
Meghna S. Motwani
Peter A. Faull
Alexis J. Seymour
Tracy T. L. Yu
Marjan Enayati
Dheraj K. Taheem
Christoph Salzlechner
Tabasom Haghighi
Ewa M. Kania
Oommen P. Oommen
Tarek Ahmed
Sandra Loaiza
Katarzyna Parzych
Francesco Dazzi
Oommen P. Varghese
Frederic Festy
Agamemnon E. Grigoriadis
Holger W. Auner
Ambrosius P. Snijders
Laurent Bozec
Eileen Gentleman
author_sort Silvia A. Ferreira
title Bi-directional cell-pericellular matrix interactions direct stem cell fate
title_short Bi-directional cell-pericellular matrix interactions direct stem cell fate
title_full Bi-directional cell-pericellular matrix interactions direct stem cell fate
title_fullStr Bi-directional cell-pericellular matrix interactions direct stem cell fate
title_full_unstemmed Bi-directional cell-pericellular matrix interactions direct stem cell fate
title_sort bi-directional cell-pericellular matrix interactions direct stem cell fate
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8af8d8a81ddc405d9f52c6d4512ee247
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