Novel peptide probes to assess the tensional state of fibronectin fibers in cancer

The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed matrix in cell culture, tissue slices and in vivo.

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Detalles Bibliográficos
Autores principales: Simon Arnoldini, Alessandra Moscaroli, Mamta Chabria, Manuel Hilbert, Samuel Hertig, Roger Schibli, Martin Béhé, Viola Vogel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8af98124e0cc41929238a7f5cc43757f
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Sumario:The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed matrix in cell culture, tissue slices and in vivo.