Novel peptide probes to assess the tensional state of fibronectin fibers in cancer

The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed matrix in cell culture, tissue slices and in vivo.

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Autores principales:	Simon Arnoldini, Alessandra Moscaroli, Mamta Chabria, Manuel Hilbert, Samuel Hertig, Roger Schibli, Martin Béhé, Viola Vogel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8af98124e0cc41929238a7f5cc43757f
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spelling	oai:doaj.org-article:8af98124e0cc41929238a7f5cc43757f2021-12-02T14:40:34ZNovel peptide probes to assess the tensional state of fibronectin fibers in cancer10.1038/s41467-017-01846-02041-1723https://doaj.org/article/8af98124e0cc41929238a7f5cc43757f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01846-0https://doaj.org/toc/2041-1723The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed matrix in cell culture, tissue slices and in vivo.Simon ArnoldiniAlessandra MoscaroliMamta ChabriaManuel HilbertSamuel HertigRoger SchibliMartin BéhéViola VogelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Arnoldini Alessandra Moscaroli Mamta Chabria Manuel Hilbert Samuel Hertig Roger Schibli Martin Béhé Viola Vogel Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
description	The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed matrix in cell culture, tissue slices and in vivo.
format	article
author	Simon Arnoldini Alessandra Moscaroli Mamta Chabria Manuel Hilbert Samuel Hertig Roger Schibli Martin Béhé Viola Vogel
author_facet	Simon Arnoldini Alessandra Moscaroli Mamta Chabria Manuel Hilbert Samuel Hertig Roger Schibli Martin Béhé Viola Vogel
author_sort	Simon Arnoldini
title	Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
title_short	Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
title_full	Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
title_fullStr	Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
title_full_unstemmed	Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
title_sort	novel peptide probes to assess the tensional state of fibronectin fibers in cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8af98124e0cc41929238a7f5cc43757f
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Novel peptide probes to assess the tensional state of fibronectin fibers in cancer

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