ANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES

Objective. The global emergence of antifungal resistance among Candida spp. is a growing threat to public health. Candida infections may resist antifungal drugs actions resulting in their therapeutic deficiency. Considering the increase rate of Candida infections and resistance to antifungal agents...

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Autor principal:	Olga Burduniuc
Formato:	article
Lenguaje:	EN RO RU
Publicado:	Association of Surgeons of the Republic of Moldova 2021
Materias:	antifungal susceptibility virulence factors Candida spp. Medicine R Surgery RD1-811
Acceso en línea:	https://doaj.org/article/8b01566329b94657b4dda19ee2f5c49e
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spelling	oai:doaj.org-article:8b01566329b94657b4dda19ee2f5c49e2021-11-04T06:37:46ZANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES10.5281/zenodo.56368571810-18521810-1879https://doaj.org/article/8b01566329b94657b4dda19ee2f5c49e2021-11-01T00:00:00Zhttps://artamedica.md/index.php/artamedica/article/view/157https://doaj.org/toc/1810-1852https://doaj.org/toc/1810-1879 Objective. The global emergence of antifungal resistance among Candida spp. is a growing threat to public health. Candida infections may resist antifungal drugs actions resulting in their therapeutic deficiency. Considering the increase rate of Candida infections and resistance to antifungal agents in the last decades, this study was conducted to evaluate the in vitro expression of different virulence factors among clinical isolates of Candida species, as well as to assay their susceptibility patterns against antifungal agents. Material and methods. Chromogenic media was used for Candida isolation. A total of 127 Candida isolates were identified by conventional methods, Vitek‑2 system. The antifungal susceptibility test was carried out by Vitek-2 system. Candida species were tested for virulence factors such as extracellular enzymes and biofilm formation by the standard phenotypic methods. Results. C. albicans continues to remain one of the most common opportunistic pathogenic fungi in humans. The authors highlighted the importance of research on understanding the mechanisms of antifungal resistance and its pathogenicity. The study demonstrates that C. albicans isolates were the most virulent and produce the highest number of extracellular enzymes: hemolysin, phospholipase, protease, esterase and catalase. The study showed the most effective antifungal agent was fucitozin (98.4%), while 29.4% isolates were resistant to fluconazole and 11.8% to voriconazole. Conclusion. C. albicans were the most virulent and produce the highest number of extracellular enzymes compared to non-albicans Candida isolates. The study showed the most effective antifungal agent was fucitozin. In conclusion, more locally relevant studies should be carried out to monitoring of the distribution and susceptibility profile. Olga BurduniucAssociation of Surgeons of the Republic of Moldovaarticleantifungal susceptibilityvirulence factorsCandida spp.MedicineRSurgeryRD1-811ENRORUArta Medica, Vol 79, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN RO RU
topic	antifungal susceptibility virulence factors Candida spp. Medicine R Surgery RD1-811
spellingShingle	antifungal susceptibility virulence factors Candida spp. Medicine R Surgery RD1-811 Olga Burduniuc ANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES
description	Objective. The global emergence of antifungal resistance among Candida spp. is a growing threat to public health. Candida infections may resist antifungal drugs actions resulting in their therapeutic deficiency. Considering the increase rate of Candida infections and resistance to antifungal agents in the last decades, this study was conducted to evaluate the in vitro expression of different virulence factors among clinical isolates of Candida species, as well as to assay their susceptibility patterns against antifungal agents. Material and methods. Chromogenic media was used for Candida isolation. A total of 127 Candida isolates were identified by conventional methods, Vitek‑2 system. The antifungal susceptibility test was carried out by Vitek-2 system. Candida species were tested for virulence factors such as extracellular enzymes and biofilm formation by the standard phenotypic methods. Results. C. albicans continues to remain one of the most common opportunistic pathogenic fungi in humans. The authors highlighted the importance of research on understanding the mechanisms of antifungal resistance and its pathogenicity. The study demonstrates that C. albicans isolates were the most virulent and produce the highest number of extracellular enzymes: hemolysin, phospholipase, protease, esterase and catalase. The study showed the most effective antifungal agent was fucitozin (98.4%), while 29.4% isolates were resistant to fluconazole and 11.8% to voriconazole. Conclusion. C. albicans were the most virulent and produce the highest number of extracellular enzymes compared to non-albicans Candida isolates. The study showed the most effective antifungal agent was fucitozin. In conclusion, more locally relevant studies should be carried out to monitoring of the distribution and susceptibility profile.
format	article
author	Olga Burduniuc
author_facet	Olga Burduniuc
author_sort	Olga Burduniuc
title	ANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES
title_short	ANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES
title_full	ANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES
title_fullStr	ANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES
title_full_unstemmed	ANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES
title_sort	antifungal susceptibility patterns and virulence factors of clinical candida spp. isolates
publisher	Association of Surgeons of the Republic of Moldova
publishDate	2021
url	https://doaj.org/article/8b01566329b94657b4dda19ee2f5c49e
work_keys_str_mv	AT olgaburduniuc antifungalsusceptibilitypatternsandvirulencefactorsofclinicalcandidasppisolates
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ANTIFUNGAL SUSCEPTIBILITY PATTERNS AND VIRULENCE FACTORS OF CLINICAL CANDIDA SPP. ISOLATES

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