Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions

Abstract Obesity, a growing health concern, is associated with an increased risk of morbidity and mortality. Chronic low-grade inflammation is implicated in obesity-driven metabolic complications. Peripheral focused ultrasound stimulation (pFUS) is an emerging non-invasive technology that modulates...

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Autores principales:	Tomás S. Huerta, Alex Devarajan, Tea Tsaava, Arvind Rishi, Victoria Cotero, Christopher Puleo, Jeffrey Ashe, Thomas R. Coleman, Eric H. Chang, Kevin J. Tracey, Sangeeta S. Chavan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b0194e0c2374c279c0e5276796cedd5
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spelling	oai:doaj.org-article:8b0194e0c2374c279c0e5276796cedd52021-12-02T13:34:57ZTargeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions10.1038/s41598-021-84330-62045-2322https://doaj.org/article/8b0194e0c2374c279c0e5276796cedd52021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84330-6https://doaj.org/toc/2045-2322Abstract Obesity, a growing health concern, is associated with an increased risk of morbidity and mortality. Chronic low-grade inflammation is implicated in obesity-driven metabolic complications. Peripheral focused ultrasound stimulation (pFUS) is an emerging non-invasive technology that modulates inflammation. Here, we reasoned that focused ultrasound stimulation of the liver may alleviate obesity-related inflammation and other comorbidities. After 8 weeks on a high-fat high-carbohydrate “Western” diet, C57BL/6J mice were subjected to either sham stimulation or focused ultrasound stimulation at the porta hepatis. Daily liver-focused ultrasound stimulation for 8 weeks significantly decreased body weight, circulating lipids and mitigated dysregulation of adipokines. In addition, liver-focused ultrasound stimulation significantly reduced hepatic cytokine levels and leukocyte infiltration. Our findings demonstrate the efficacy of hepatic focused ultrasound for alleviating obesity and obesity-associated complications in mice. These findings suggest a previously unrecognized potential of hepatic focused ultrasound as a possible novel noninvasive approach in the context of obesity.Tomás S. HuertaAlex DevarajanTea TsaavaArvind RishiVictoria CoteroChristopher PuleoJeffrey AsheThomas R. ColemanEric H. ChangKevin J. TraceySangeeta S. ChavanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomás S. Huerta Alex Devarajan Tea Tsaava Arvind Rishi Victoria Cotero Christopher Puleo Jeffrey Ashe Thomas R. Coleman Eric H. Chang Kevin J. Tracey Sangeeta S. Chavan Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions
description	Abstract Obesity, a growing health concern, is associated with an increased risk of morbidity and mortality. Chronic low-grade inflammation is implicated in obesity-driven metabolic complications. Peripheral focused ultrasound stimulation (pFUS) is an emerging non-invasive technology that modulates inflammation. Here, we reasoned that focused ultrasound stimulation of the liver may alleviate obesity-related inflammation and other comorbidities. After 8 weeks on a high-fat high-carbohydrate “Western” diet, C57BL/6J mice were subjected to either sham stimulation or focused ultrasound stimulation at the porta hepatis. Daily liver-focused ultrasound stimulation for 8 weeks significantly decreased body weight, circulating lipids and mitigated dysregulation of adipokines. In addition, liver-focused ultrasound stimulation significantly reduced hepatic cytokine levels and leukocyte infiltration. Our findings demonstrate the efficacy of hepatic focused ultrasound for alleviating obesity and obesity-associated complications in mice. These findings suggest a previously unrecognized potential of hepatic focused ultrasound as a possible novel noninvasive approach in the context of obesity.
format	article
author	Tomás S. Huerta Alex Devarajan Tea Tsaava Arvind Rishi Victoria Cotero Christopher Puleo Jeffrey Ashe Thomas R. Coleman Eric H. Chang Kevin J. Tracey Sangeeta S. Chavan
author_facet	Tomás S. Huerta Alex Devarajan Tea Tsaava Arvind Rishi Victoria Cotero Christopher Puleo Jeffrey Ashe Thomas R. Coleman Eric H. Chang Kevin J. Tracey Sangeeta S. Chavan
author_sort	Tomás S. Huerta
title	Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions
title_short	Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions
title_full	Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions
title_fullStr	Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions
title_full_unstemmed	Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions
title_sort	targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b0194e0c2374c279c0e5276796cedd5
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Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions

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