OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of keratinocyte death, thereby implicating a functio...

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Autores principales: Esther Hoste, Kim Lecomte, Karl Annusver, Niels Vandamme, Jana Roels, Sophia Maschalidi, Lien Verboom, Hanna-Kaisa Vikkula, Mozes Sze, Lisette Van Hove, Kevin Verstaen, Arne Martens, Tino Hochepied, Yvan Saeys, Kodi Ravichandran, Maria Kasper, Geert van Loo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/8b051a56d99b49d783afe85a0b01f20a
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spelling oai:doaj.org-article:8b051a56d99b49d783afe85a0b01f20a2021-12-02T16:57:08ZOTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity10.1038/s41467-021-25944-22041-1723https://doaj.org/article/8b051a56d99b49d783afe85a0b01f20a2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25944-2https://doaj.org/toc/2041-1723OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of keratinocyte death, thereby implicating a function of OTULIN in keratinocyte homeostasis.Esther HosteKim LecomteKarl AnnusverNiels VandammeJana RoelsSophia MaschalidiLien VerboomHanna-Kaisa VikkulaMozes SzeLisette Van HoveKevin VerstaenArne MartensTino HochepiedYvan SaeysKodi RavichandranMaria KasperGeert van LooNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Esther Hoste
Kim Lecomte
Karl Annusver
Niels Vandamme
Jana Roels
Sophia Maschalidi
Lien Verboom
Hanna-Kaisa Vikkula
Mozes Sze
Lisette Van Hove
Kevin Verstaen
Arne Martens
Tino Hochepied
Yvan Saeys
Kodi Ravichandran
Maria Kasper
Geert van Loo
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
description OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of keratinocyte death, thereby implicating a function of OTULIN in keratinocyte homeostasis.
format article
author Esther Hoste
Kim Lecomte
Karl Annusver
Niels Vandamme
Jana Roels
Sophia Maschalidi
Lien Verboom
Hanna-Kaisa Vikkula
Mozes Sze
Lisette Van Hove
Kevin Verstaen
Arne Martens
Tino Hochepied
Yvan Saeys
Kodi Ravichandran
Maria Kasper
Geert van Loo
author_facet Esther Hoste
Kim Lecomte
Karl Annusver
Niels Vandamme
Jana Roels
Sophia Maschalidi
Lien Verboom
Hanna-Kaisa Vikkula
Mozes Sze
Lisette Van Hove
Kevin Verstaen
Arne Martens
Tino Hochepied
Yvan Saeys
Kodi Ravichandran
Maria Kasper
Geert van Loo
author_sort Esther Hoste
title OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
title_short OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
title_full OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
title_fullStr OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
title_full_unstemmed OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
title_sort otulin maintains skin homeostasis by controlling keratinocyte death and stem cell identity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/8b051a56d99b49d783afe85a0b01f20a
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