The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors

Abstract Healthy lifestyle interventions and drug therapies are proven to have a positive preventative influence on normal glucose regulation in prediabetes. However, little is known on the specific role that these factors play on reversion to normal glycemia according to type of prediabetes. We use...

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Autores principales:	Carolina Giráldez-García, Lucía Cea-Soriano, Romana Albaladejo, Josep Franch-Nadal, Manel Mata-Cases, Javier Díez-Espino, Sara Artola, Rosario Serrano, Enrique Regidor, for the PREDAPS Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b06e911094f47fb88a1eb840622937b
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spelling	oai:doaj.org-article:8b06e911094f47fb88a1eb840622937b2021-12-02T15:38:10ZThe heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors10.1038/s41598-021-87838-z2045-2322https://doaj.org/article/8b06e911094f47fb88a1eb840622937b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87838-zhttps://doaj.org/toc/2045-2322Abstract Healthy lifestyle interventions and drug therapies are proven to have a positive preventative influence on normal glucose regulation in prediabetes. However, little is known on the specific role that these factors play on reversion to normal glycemia according to type of prediabetes. We used data from the Observational prospective cohort study, The Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes from 2012 to 2015. A total of 1184 individuals aged 30–74 years old were included and classified based on the ADA in three mutually exclusive groups using either fasting plasma glucose (FPG) levels (from 100 to 125 mg/dl, FPG group), HbA1c (5.7–6.4%, HbA1c group) or both impaired parameters. Information on lifestyle factors and biochemical parameters were collected at baseline. Reversion to normal glucose regulation was calculated at third year of follow-up. Relationship of lifestyle factor and type of prediabetes with reversion were estimated using odds ratios (ORs) with 95% confidence intervals (95% CIs) adjusting by different groups of confounders. Proportion of reversion rates were 31% for FPG group, 31% for HbA1c group and 7.9% for both altered parameters group, respectively. Optimal life style factors such as BMI < 25 kg/m2[OR (95% CI): 1.90 (1.20–3.01)], high adherence to Mediterranean diet 1.78 (1.21–2.63) and absence of abdominal obesity 1.70 (1.19–2.43) were the strongest predictors for reversion to normal glucose. However, those did not modify the ORs of reversion to normal glucose. Taking as reference those with both impaired parameters, subjects with FPG impairment (FPG group) had an OR of 4.87 (3.10–7.65) and 3.72 (2.39–5.78) for HbA1c group. These estimates remained almost the same after further adjustment for biochemical parameters and lifestyle factors (4.55(2.84–7.28) and 3.09 (1.92–4.97), respectively). Optimal lifestyle factors showed to be a positive predictor for reversion to normal glucose regulation however, the differences of reversion risk according type of prediabetes are not explained by lifestyle factors.Carolina Giráldez-GarcíaLucía Cea-SorianoRomana AlbaladejoJosep Franch-NadalManel Mata-CasesJavier Díez-EspinoSara ArtolaRosario SerranoEnrique Regidorfor the PREDAPS Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carolina Giráldez-García Lucía Cea-Soriano Romana Albaladejo Josep Franch-Nadal Manel Mata-Cases Javier Díez-Espino Sara Artola Rosario Serrano Enrique Regidor for the PREDAPS Study Group The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors
description	Abstract Healthy lifestyle interventions and drug therapies are proven to have a positive preventative influence on normal glucose regulation in prediabetes. However, little is known on the specific role that these factors play on reversion to normal glycemia according to type of prediabetes. We used data from the Observational prospective cohort study, The Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes from 2012 to 2015. A total of 1184 individuals aged 30–74 years old were included and classified based on the ADA in three mutually exclusive groups using either fasting plasma glucose (FPG) levels (from 100 to 125 mg/dl, FPG group), HbA1c (5.7–6.4%, HbA1c group) or both impaired parameters. Information on lifestyle factors and biochemical parameters were collected at baseline. Reversion to normal glucose regulation was calculated at third year of follow-up. Relationship of lifestyle factor and type of prediabetes with reversion were estimated using odds ratios (ORs) with 95% confidence intervals (95% CIs) adjusting by different groups of confounders. Proportion of reversion rates were 31% for FPG group, 31% for HbA1c group and 7.9% for both altered parameters group, respectively. Optimal life style factors such as BMI < 25 kg/m2[OR (95% CI): 1.90 (1.20–3.01)], high adherence to Mediterranean diet 1.78 (1.21–2.63) and absence of abdominal obesity 1.70 (1.19–2.43) were the strongest predictors for reversion to normal glucose. However, those did not modify the ORs of reversion to normal glucose. Taking as reference those with both impaired parameters, subjects with FPG impairment (FPG group) had an OR of 4.87 (3.10–7.65) and 3.72 (2.39–5.78) for HbA1c group. These estimates remained almost the same after further adjustment for biochemical parameters and lifestyle factors (4.55(2.84–7.28) and 3.09 (1.92–4.97), respectively). Optimal lifestyle factors showed to be a positive predictor for reversion to normal glucose regulation however, the differences of reversion risk according type of prediabetes are not explained by lifestyle factors.
format	article
author	Carolina Giráldez-García Lucía Cea-Soriano Romana Albaladejo Josep Franch-Nadal Manel Mata-Cases Javier Díez-Espino Sara Artola Rosario Serrano Enrique Regidor for the PREDAPS Study Group
author_facet	Carolina Giráldez-García Lucía Cea-Soriano Romana Albaladejo Josep Franch-Nadal Manel Mata-Cases Javier Díez-Espino Sara Artola Rosario Serrano Enrique Regidor for the PREDAPS Study Group
author_sort	Carolina Giráldez-García
title	The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors
title_short	The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors
title_full	The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors
title_fullStr	The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors
title_full_unstemmed	The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors
title_sort	heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b06e911094f47fb88a1eb840622937b
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The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors

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