Diabetes and dyslipidemia: characterizing lipoprotein metabolism

GH Tomkin,1,2 D Owens1,2 1Diabetes Institute of Ireland, Beacon Hospital, 2Trinity College, University of Dublin, Dublin, Ireland Abstract: Premature atherosclerosis in diabetes accounts for much of the decreased life span. New treatments have reduced this risk considerably. This review explores the...

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Autores principales:	Tomkin GH, Owens D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Obesity type 2 diabetes dyslipidaemia low density lipoprotein LDL fibroblast growth (factor FGF) forkhead transcription factor (FOX)O1 farnesyl X transcription factors (FRX) Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8b09564257c546a59438a0c394a77c8c
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spelling	oai:doaj.org-article:8b09564257c546a59438a0c394a77c8c2021-12-02T06:51:19ZDiabetes and dyslipidemia: characterizing lipoprotein metabolism1178-7007https://doaj.org/article/8b09564257c546a59438a0c394a77c8c2017-07-01T00:00:00Zhttps://www.dovepress.com/diabetes-and-dyslipidemia-characterizing-lipoprotein-metabolism-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007GH Tomkin,1,2 D Owens1,2 1Diabetes Institute of Ireland, Beacon Hospital, 2Trinity College, University of Dublin, Dublin, Ireland Abstract: Premature atherosclerosis in diabetes accounts for much of the decreased life span. New treatments have reduced this risk considerably. This review explores the relationship among the disturbances in glucose, lipid, and bile salt metabolic pathways that occur in diabetes. In particular, excess nutrient intake and starvation have major metabolic effects, which have allowed us new insights into the disturbance that occurs in diabetes. Metabolic regulators such as the forkhead transcription factors, the farnesyl X transcription factors, and the fibroblast growth factors have become important players in our understanding of the dysregulation of metabolism in diabetes and overnutrition. The disturbed regulation of lipoprotein metabolism in both the intestine and the liver has been more clearly defined over the past few years, and the atherogenicity of the triglyceride-rich lipoproteins, and – in tandem – low levels of high-density lipoproteins, is seen now as very important. New information on the apolipoproteins that control lipoprotein lipase activity has been obtained. This is an exciting time in the battle to defeat diabetic atherosclerosis. Keywords: obesity, type 2 diabetes, dyslipidemia, low-density lipoprotein, fibroblast growth factor, forkhead transcription factor O1, farnesyl X transcription factors Tomkin GHOwens DDove Medical PressarticleObesitytype 2 diabetesdyslipidaemialow density lipoprotein LDLfibroblast growth (factor FGF) forkhead transcription factor (FOX)O1farnesyl X transcription factors (FRX)Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 333-343 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obesity type 2 diabetes dyslipidaemia low density lipoprotein LDL fibroblast growth (factor FGF) forkhead transcription factor (FOX)O1 farnesyl X transcription factors (FRX) Specialties of internal medicine RC581-951
spellingShingle	Obesity type 2 diabetes dyslipidaemia low density lipoprotein LDL fibroblast growth (factor FGF) forkhead transcription factor (FOX)O1 farnesyl X transcription factors (FRX) Specialties of internal medicine RC581-951 Tomkin GH Owens D Diabetes and dyslipidemia: characterizing lipoprotein metabolism
description	GH Tomkin,1,2 D Owens1,2 1Diabetes Institute of Ireland, Beacon Hospital, 2Trinity College, University of Dublin, Dublin, Ireland Abstract: Premature atherosclerosis in diabetes accounts for much of the decreased life span. New treatments have reduced this risk considerably. This review explores the relationship among the disturbances in glucose, lipid, and bile salt metabolic pathways that occur in diabetes. In particular, excess nutrient intake and starvation have major metabolic effects, which have allowed us new insights into the disturbance that occurs in diabetes. Metabolic regulators such as the forkhead transcription factors, the farnesyl X transcription factors, and the fibroblast growth factors have become important players in our understanding of the dysregulation of metabolism in diabetes and overnutrition. The disturbed regulation of lipoprotein metabolism in both the intestine and the liver has been more clearly defined over the past few years, and the atherogenicity of the triglyceride-rich lipoproteins, and – in tandem – low levels of high-density lipoproteins, is seen now as very important. New information on the apolipoproteins that control lipoprotein lipase activity has been obtained. This is an exciting time in the battle to defeat diabetic atherosclerosis. Keywords: obesity, type 2 diabetes, dyslipidemia, low-density lipoprotein, fibroblast growth factor, forkhead transcription factor O1, farnesyl X transcription factors
format	article
author	Tomkin GH Owens D
author_facet	Tomkin GH Owens D
author_sort	Tomkin GH
title	Diabetes and dyslipidemia: characterizing lipoprotein metabolism
title_short	Diabetes and dyslipidemia: characterizing lipoprotein metabolism
title_full	Diabetes and dyslipidemia: characterizing lipoprotein metabolism
title_fullStr	Diabetes and dyslipidemia: characterizing lipoprotein metabolism
title_full_unstemmed	Diabetes and dyslipidemia: characterizing lipoprotein metabolism
title_sort	diabetes and dyslipidemia: characterizing lipoprotein metabolism
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8b09564257c546a59438a0c394a77c8c
work_keys_str_mv	AT tomkingh diabetesanddyslipidemiacharacterizinglipoproteinmetabolism AT owensd diabetesanddyslipidemiacharacterizinglipoproteinmetabolism
_version_	1718399704284266496

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

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