Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments

Polymeric biomaterials exhibit excellent physicochemical characteristics as a scaffold for cell and tissue engineering applications. Chemical modification of the polymers has been the primary mode of functionalization to enhance biocompatibility and regulate cellular behaviors such as cell adhesion,...

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Autores principales:	Youyi Tai, Aihik Banerjee, Robyn Goodrich, Lu Jin, Jin Nam
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polymeric scaffold multifunctional physical stimuli tissue engineering Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/8b09903f6a3d465d8ba5fe07f5dfb9d5
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spelling	oai:doaj.org-article:8b09903f6a3d465d8ba5fe07f5dfb9d52021-11-25T18:47:53ZDevelopment and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments10.3390/polym132238802073-4360https://doaj.org/article/8b09903f6a3d465d8ba5fe07f5dfb9d52021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3880https://doaj.org/toc/2073-4360Polymeric biomaterials exhibit excellent physicochemical characteristics as a scaffold for cell and tissue engineering applications. Chemical modification of the polymers has been the primary mode of functionalization to enhance biocompatibility and regulate cellular behaviors such as cell adhesion, proliferation, differentiation, and maturation. Due to the complexity of the in vivo cellular microenvironments, however, chemical functionalization alone is usually insufficient to develop functionally mature cells/tissues. Therefore, the multifunctional polymeric scaffolds that enable electrical, mechanical, and/or magnetic stimulation to the cells, have gained research interest in the past decade. Such multifunctional scaffolds are often combined with exogenous stimuli to further enhance the tissue and cell behaviors by dynamically controlling the microenvironments of the cells. Significantly improved cell proliferation and differentiation, as well as tissue functionalities, are frequently observed by applying extrinsic physical stimuli on functional polymeric scaffold systems. In this regard, the present paper discusses the current state-of-the-art functionalized polymeric scaffolds, with an emphasis on electrospun fibers, that modulate the physical cell niche to direct cellular behaviors and subsequent functional tissue development. We will also highlight the incorporation of the extrinsic stimuli to augment or activate the functionalized polymeric scaffold system to dynamically stimulate the cells.Youyi TaiAihik BanerjeeRobyn GoodrichLu JinJin NamMDPI AGarticlepolymeric scaffoldmultifunctionalphysical stimulitissue engineeringOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3880, p 3880 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymeric scaffold multifunctional physical stimuli tissue engineering Organic chemistry QD241-441
spellingShingle	polymeric scaffold multifunctional physical stimuli tissue engineering Organic chemistry QD241-441 Youyi Tai Aihik Banerjee Robyn Goodrich Lu Jin Jin Nam Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments
description	Polymeric biomaterials exhibit excellent physicochemical characteristics as a scaffold for cell and tissue engineering applications. Chemical modification of the polymers has been the primary mode of functionalization to enhance biocompatibility and regulate cellular behaviors such as cell adhesion, proliferation, differentiation, and maturation. Due to the complexity of the in vivo cellular microenvironments, however, chemical functionalization alone is usually insufficient to develop functionally mature cells/tissues. Therefore, the multifunctional polymeric scaffolds that enable electrical, mechanical, and/or magnetic stimulation to the cells, have gained research interest in the past decade. Such multifunctional scaffolds are often combined with exogenous stimuli to further enhance the tissue and cell behaviors by dynamically controlling the microenvironments of the cells. Significantly improved cell proliferation and differentiation, as well as tissue functionalities, are frequently observed by applying extrinsic physical stimuli on functional polymeric scaffold systems. In this regard, the present paper discusses the current state-of-the-art functionalized polymeric scaffolds, with an emphasis on electrospun fibers, that modulate the physical cell niche to direct cellular behaviors and subsequent functional tissue development. We will also highlight the incorporation of the extrinsic stimuli to augment or activate the functionalized polymeric scaffold system to dynamically stimulate the cells.
format	article
author	Youyi Tai Aihik Banerjee Robyn Goodrich Lu Jin Jin Nam
author_facet	Youyi Tai Aihik Banerjee Robyn Goodrich Lu Jin Jin Nam
author_sort	Youyi Tai
title	Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments
title_short	Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments
title_full	Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments
title_fullStr	Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments
title_full_unstemmed	Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments
title_sort	development and utilization of multifunctional polymeric scaffolds for the regulation of physical cellular microenvironments
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8b09903f6a3d465d8ba5fe07f5dfb9d5
work_keys_str_mv	AT youyitai developmentandutilizationofmultifunctionalpolymericscaffoldsfortheregulationofphysicalcellularmicroenvironments AT aihikbanerjee developmentandutilizationofmultifunctionalpolymericscaffoldsfortheregulationofphysicalcellularmicroenvironments AT robyngoodrich developmentandutilizationofmultifunctionalpolymericscaffoldsfortheregulationofphysicalcellularmicroenvironments AT lujin developmentandutilizationofmultifunctionalpolymericscaffoldsfortheregulationofphysicalcellularmicroenvironments AT jinnam developmentandutilizationofmultifunctionalpolymericscaffoldsfortheregulationofphysicalcellularmicroenvironments
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Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments

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