Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer

Here, the authors use whole exome sequencing to determine the effect of tumor mutational burden (TMB) and chromosomal aneuploidy (ANE) on survival outcomes of non-small cell lung cancer patients undergoing radiotherapy. The authors find that a higher TMB and lower ANE were correlated with better sur...

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Autores principales:	Qingzhu Jia, Qian Chu, Anmei Zhang, Jing Yu, Fangfang Liu, Kaiyu Qian, Yu Xiao, Xue Wang, Ying Yang, Yi Zhao, Ji He, Guanghui Li, Yisong Y. Wan, Conghua Xie, Bo Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8b0b7a3e0aa74c93b93c8d76f943e280
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spelling	oai:doaj.org-article:8b0b7a3e0aa74c93b93c8d76f943e2802021-12-02T14:16:06ZMutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer10.1038/s42003-021-01657-62399-3642https://doaj.org/article/8b0b7a3e0aa74c93b93c8d76f943e2802021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01657-6https://doaj.org/toc/2399-3642Here, the authors use whole exome sequencing to determine the effect of tumor mutational burden (TMB) and chromosomal aneuploidy (ANE) on survival outcomes of non-small cell lung cancer patients undergoing radiotherapy. The authors find that a higher TMB and lower ANE were correlated with better survival outcomes and that these factors interact synergistically.Qingzhu JiaQian ChuAnmei ZhangJing YuFangfang LiuKaiyu QianYu XiaoXue WangYing YangYi ZhaoJi HeGuanghui LiYisong Y. WanConghua XieBo ZhuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Qingzhu Jia Qian Chu Anmei Zhang Jing Yu Fangfang Liu Kaiyu Qian Yu Xiao Xue Wang Ying Yang Yi Zhao Ji He Guanghui Li Yisong Y. Wan Conghua Xie Bo Zhu Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer
description	Here, the authors use whole exome sequencing to determine the effect of tumor mutational burden (TMB) and chromosomal aneuploidy (ANE) on survival outcomes of non-small cell lung cancer patients undergoing radiotherapy. The authors find that a higher TMB and lower ANE were correlated with better survival outcomes and that these factors interact synergistically.
format	article
author	Qingzhu Jia Qian Chu Anmei Zhang Jing Yu Fangfang Liu Kaiyu Qian Yu Xiao Xue Wang Ying Yang Yi Zhao Ji He Guanghui Li Yisong Y. Wan Conghua Xie Bo Zhu
author_facet	Qingzhu Jia Qian Chu Anmei Zhang Jing Yu Fangfang Liu Kaiyu Qian Yu Xiao Xue Wang Ying Yang Yi Zhao Ji He Guanghui Li Yisong Y. Wan Conghua Xie Bo Zhu
author_sort	Qingzhu Jia
title	Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer
title_short	Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer
title_full	Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer
title_fullStr	Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer
title_full_unstemmed	Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer
title_sort	mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b0b7a3e0aa74c93b93c8d76f943e280
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Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer

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