Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome

Background. Atypical hemolytic uremic syndrome (aHUS) is an important cause of acute kidney injury in children. It is primarily caused by dysregulation of the complement alternative pathway due to genetic mutations, mainly in complement factor H genes, or due to anti-factor H autoantibodies (anti-FH...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shereen Shawky, Hesham Safouh, Mona Gamal, Mohammed M. Abbas, Azza Aboul-Enein, Toshihiro Sawai, Yosra Fahmy, Heba Selim
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/8b0e4b27900e422fa8ee55ee2fe4894b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b0e4b27900e422fa8ee55ee2fe4894b
record_format	dspace
spelling	oai:doaj.org-article:8b0e4b27900e422fa8ee55ee2fe4894b2021-11-29T00:56:04ZAnti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome2090-215810.1155/2021/6904858https://doaj.org/article/8b0e4b27900e422fa8ee55ee2fe4894b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6904858https://doaj.org/toc/2090-2158Background. Atypical hemolytic uremic syndrome (aHUS) is an important cause of acute kidney injury in children. It is primarily caused by dysregulation of the complement alternative pathway due to genetic mutations, mainly in complement factor H genes, or due to anti-factor H autoantibodies (anti-FH), leading to uncontrolled overactivation of the complement system. Early diagnosis and treatment of autoimmune HUS (AI-HUS) is essential and leads to a favorable outcome. Methods. Fifty pediatric HUS patients and 50 age- and sex-matched controls were included in the study. Patients were subjected to full history taking, clinical examination, and laboratory testing. All candidates were subjected to an assessment of anti-FH in serum by a homemade enzyme-linked immunosorbent assay technique. Results. A high frequency of serum anti-FH was detected in our aHUS patients. The disease onset of AI-HUS was mainly observed in March and April, with significantly higher rates in school-aged males. All patients who started immunosuppressives early together with plasmapheresis upon detection of their anti-FH had complete renal function recovery. Conclusion. The high frequency of AI-HUS revealed in Egyptian HUS children in our study highlights the importance of implementing anti-FH testing in Egypt to provide early recognition for immediate proper management, including early immunosuppressive therapy, and hence improving patient outcomes.Shereen ShawkyHesham SafouhMona GamalMohammed M. AbbasAzza Aboul-EneinToshihiro SawaiYosra FahmyHeba SelimHindawi LimitedarticleDiseases of the genitourinary system. UrologyRC870-923ENInternational Journal of Nephrology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Shereen Shawky Hesham Safouh Mona Gamal Mohammed M. Abbas Azza Aboul-Enein Toshihiro Sawai Yosra Fahmy Heba Selim Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome
description	Background. Atypical hemolytic uremic syndrome (aHUS) is an important cause of acute kidney injury in children. It is primarily caused by dysregulation of the complement alternative pathway due to genetic mutations, mainly in complement factor H genes, or due to anti-factor H autoantibodies (anti-FH), leading to uncontrolled overactivation of the complement system. Early diagnosis and treatment of autoimmune HUS (AI-HUS) is essential and leads to a favorable outcome. Methods. Fifty pediatric HUS patients and 50 age- and sex-matched controls were included in the study. Patients were subjected to full history taking, clinical examination, and laboratory testing. All candidates were subjected to an assessment of anti-FH in serum by a homemade enzyme-linked immunosorbent assay technique. Results. A high frequency of serum anti-FH was detected in our aHUS patients. The disease onset of AI-HUS was mainly observed in March and April, with significantly higher rates in school-aged males. All patients who started immunosuppressives early together with plasmapheresis upon detection of their anti-FH had complete renal function recovery. Conclusion. The high frequency of AI-HUS revealed in Egyptian HUS children in our study highlights the importance of implementing anti-FH testing in Egypt to provide early recognition for immediate proper management, including early immunosuppressive therapy, and hence improving patient outcomes.
format	article
author	Shereen Shawky Hesham Safouh Mona Gamal Mohammed M. Abbas Azza Aboul-Enein Toshihiro Sawai Yosra Fahmy Heba Selim
author_facet	Shereen Shawky Hesham Safouh Mona Gamal Mohammed M. Abbas Azza Aboul-Enein Toshihiro Sawai Yosra Fahmy Heba Selim
author_sort	Shereen Shawky
title	Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome
title_short	Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome
title_full	Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome
title_fullStr	Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome
title_full_unstemmed	Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome
title_sort	anti-factor h antibodies in egyptian children with hemolytic uremic syndrome
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/8b0e4b27900e422fa8ee55ee2fe4894b
work_keys_str_mv	AT shereenshawky antifactorhantibodiesinegyptianchildrenwithhemolyticuremicsyndrome AT heshamsafouh antifactorhantibodiesinegyptianchildrenwithhemolyticuremicsyndrome AT monagamal antifactorhantibodiesinegyptianchildrenwithhemolyticuremicsyndrome AT mohammedmabbas antifactorhantibodiesinegyptianchildrenwithhemolyticuremicsyndrome AT azzaaboulenein antifactorhantibodiesinegyptianchildrenwithhemolyticuremicsyndrome AT toshihirosawai antifactorhantibodiesinegyptianchildrenwithhemolyticuremicsyndrome AT yosrafahmy antifactorhantibodiesinegyptianchildrenwithhemolyticuremicsyndrome AT hebaselim antifactorhantibodiesinegyptianchildrenwithhemolyticuremicsyndrome
_version_	1718407718969016320

Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome

Ejemplares similares