Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China

Junxiu Cai,1,2,* Yan Zhang,3,* Rebiya Nuli,4 Yangyi Zhang,5 Manfutong Abudusemaiti,5 Aizhatiguli Kadeer,6 Xiaoli Tian,5 Hui Xiao5 1Department of Occupational and Environmental Health, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 2Medic...

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Autores principales:	Cai J, Zhang Y, Nuli R, Abudusemaiti M, Kadeer A, Tian X, Xiao H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Type 2 diabetes mellitus dietary patterns TCF7L2 polymorphism Uyghur Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8b1069f193b943388efb3bd6f0c85703
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spelling	oai:doaj.org-article:8b1069f193b943388efb3bd6f0c857032021-12-02T02:20:20ZInteraction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China1178-7007https://doaj.org/article/8b1069f193b943388efb3bd6f0c857032019-02-01T00:00:00Zhttps://www.dovepress.com/interaction-between-dietary-patterns-and-tcf7l2-polymorphisms-on-type--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Junxiu Cai,1,2,* Yan Zhang,3,* Rebiya Nuli,4 Yangyi Zhang,5 Manfutong Abudusemaiti,5 Aizhatiguli Kadeer,6 Xiaoli Tian,5 Hui Xiao5 1Department of Occupational and Environmental Health, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 2Medical Department, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 3Department of Pathology, Basic Medical Science Institute, International Education College, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 4Department of Human Parasitology, Basic Medical Science Institute, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 5Department of Nutrition and Food Hygiene, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 6Department of Epidemiology and Statistics, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China *These authors contributed equally to this work Purpose: This study aimed to characterize dietary patterns in the Uyghur population and examined the relationship between dietary pattern, TCF7L2 single-nucleotide polymorphisms (SNPs), and the risk of type 2 diabetes mellitus (T2DM).Patients and methods: Dietary patterns were defined using factor analysis, and associations between dietary patterns were evaluated using multivariate logistic regression analyses. Genotyping of seven SNPs of TCF7L2 (rs11196205, rs12255372, rs12573128, rs4506565, rs7895340, rs7901695, and rs7903146) was conducted, and the association between these seven SNPs and the risk of T2DM was evaluated. Interactions between SNPs, homeostasis model assessment-insulin resistance, and dietary patterns were also analyzed.Results: A total of 828 participants were enrolled in this study, including 491 people with T2DM and 337 healthy controls. Five dietary patterns were defined, and the results indicated that the “fruit” and “vegetables” dietary patterns were associated with a significant decrease in the risk of T2DM, whereas the “meats” and “grains” dietary patterns were associated with an increased risk of T2DM. Moreover, the “dairy product” dietary pattern showed no association with the risk of T2DM. Furthermore, our results revealed that the TCF7L2 SNP, rs12573128, is associated with an increased risk of T2DM. SNPs rs4506565 and rs7903146 significantly interacted with dietary pattern.Conclusion: Our studies suggest that dietary pattern and genetic polymorphisms of TCF7L2 are associated with the development of T2DM in the Uyghur population of China. Keywords: type 2 diabetes mellitus, dietary patterns, TCF7L2, polymorphism, Uyghur  Cai JZhang YNuli RZhang YAbudusemaiti MKadeer ATian XXiao HDove Medical PressarticleType 2 diabetes mellitusdietary patternsTCF7L2polymorphismUyghurSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 239-255 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes mellitus dietary patterns TCF7L2 polymorphism Uyghur Specialties of internal medicine RC581-951
spellingShingle	Type 2 diabetes mellitus dietary patterns TCF7L2 polymorphism Uyghur Specialties of internal medicine RC581-951 Cai J Zhang Y Nuli R Zhang Y Abudusemaiti M Kadeer A Tian X Xiao H Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China
description	Junxiu Cai,1,2,* Yan Zhang,3,* Rebiya Nuli,4 Yangyi Zhang,5 Manfutong Abudusemaiti,5 Aizhatiguli Kadeer,6 Xiaoli Tian,5 Hui Xiao5 1Department of Occupational and Environmental Health, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 2Medical Department, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 3Department of Pathology, Basic Medical Science Institute, International Education College, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 4Department of Human Parasitology, Basic Medical Science Institute, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 5Department of Nutrition and Food Hygiene, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 6Department of Epidemiology and Statistics, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China *These authors contributed equally to this work Purpose: This study aimed to characterize dietary patterns in the Uyghur population and examined the relationship between dietary pattern, TCF7L2 single-nucleotide polymorphisms (SNPs), and the risk of type 2 diabetes mellitus (T2DM).Patients and methods: Dietary patterns were defined using factor analysis, and associations between dietary patterns were evaluated using multivariate logistic regression analyses. Genotyping of seven SNPs of TCF7L2 (rs11196205, rs12255372, rs12573128, rs4506565, rs7895340, rs7901695, and rs7903146) was conducted, and the association between these seven SNPs and the risk of T2DM was evaluated. Interactions between SNPs, homeostasis model assessment-insulin resistance, and dietary patterns were also analyzed.Results: A total of 828 participants were enrolled in this study, including 491 people with T2DM and 337 healthy controls. Five dietary patterns were defined, and the results indicated that the “fruit” and “vegetables” dietary patterns were associated with a significant decrease in the risk of T2DM, whereas the “meats” and “grains” dietary patterns were associated with an increased risk of T2DM. Moreover, the “dairy product” dietary pattern showed no association with the risk of T2DM. Furthermore, our results revealed that the TCF7L2 SNP, rs12573128, is associated with an increased risk of T2DM. SNPs rs4506565 and rs7903146 significantly interacted with dietary pattern.Conclusion: Our studies suggest that dietary pattern and genetic polymorphisms of TCF7L2 are associated with the development of T2DM in the Uyghur population of China. Keywords: type 2 diabetes mellitus, dietary patterns, TCF7L2, polymorphism, Uyghur
format	article
author	Cai J Zhang Y Nuli R Zhang Y Abudusemaiti M Kadeer A Tian X Xiao H
author_facet	Cai J Zhang Y Nuli R Zhang Y Abudusemaiti M Kadeer A Tian X Xiao H
author_sort	Cai J
title	Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China
title_short	Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China
title_full	Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China
title_fullStr	Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China
title_full_unstemmed	Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China
title_sort	interaction between dietary patterns and tcf7l2 polymorphisms on type 2 diabetes mellitus among uyghur adults in xinjiang province, china
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8b1069f193b943388efb3bd6f0c85703
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Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China

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