SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression

SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression

Abstract SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis. Here, we show that SMYD3 modulates another hallmark of cancer, DNA repair, by stimulating transcription of genes inv...

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Autores principales: Yun-Ju Chen, Cheng-Hui Tsai, Pin-Yu Wang, Shu-Chun Teng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8b12ae6cfb12445e9427d337286f3466
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spelling oai:doaj.org-article:8b12ae6cfb12445e9427d337286f34662021-12-02T11:40:50ZSMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression10.1038/s41598-017-03385-62045-2322https://doaj.org/article/8b12ae6cfb12445e9427d337286f34662017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03385-6https://doaj.org/toc/2045-2322Abstract SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis. Here, we show that SMYD3 modulates another hallmark of cancer, DNA repair, by stimulating transcription of genes involved in multiple steps of homologous recombination. Deficiency of SMYD3 induces DNA-damage hypersensitivity, decreases levels of repair foci, and leads to impairment of homologous recombination. Moreover, the regulation of homologous recombination-related genes is via the methylation of H3K4 at the target gene promoters. These data imply that, besides its reported oncogenic abilities, SMYD3 may maintain genome integrity by ensuring expression levels of HR proteins to cope with the high demand of restart of stalled replication forks in cancers.Yun-Ju ChenCheng-Hui TsaiPin-Yu WangShu-Chun TengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yun-Ju Chen
Cheng-Hui Tsai
Pin-Yu Wang
Shu-Chun Teng
SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
description Abstract SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis. Here, we show that SMYD3 modulates another hallmark of cancer, DNA repair, by stimulating transcription of genes involved in multiple steps of homologous recombination. Deficiency of SMYD3 induces DNA-damage hypersensitivity, decreases levels of repair foci, and leads to impairment of homologous recombination. Moreover, the regulation of homologous recombination-related genes is via the methylation of H3K4 at the target gene promoters. These data imply that, besides its reported oncogenic abilities, SMYD3 may maintain genome integrity by ensuring expression levels of HR proteins to cope with the high demand of restart of stalled replication forks in cancers.
format article
author Yun-Ju Chen
Cheng-Hui Tsai
Pin-Yu Wang
Shu-Chun Teng
author_facet Yun-Ju Chen
Cheng-Hui Tsai
Pin-Yu Wang
Shu-Chun Teng
author_sort Yun-Ju Chen
title SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
title_short SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
title_full SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
title_fullStr SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
title_full_unstemmed SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
title_sort smyd3 promotes homologous recombination via regulation of h3k4-mediated gene expression
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8b12ae6cfb12445e9427d337286f3466
work_keys_str_mv AT yunjuchen smyd3promoteshomologousrecombinationviaregulationofh3k4mediatedgeneexpression
AT chenghuitsai smyd3promoteshomologousrecombinationviaregulationofh3k4mediatedgeneexpression
AT pinyuwang smyd3promoteshomologousrecombinationviaregulationofh3k4mediatedgeneexpression
AT shuchunteng smyd3promoteshomologousrecombinationviaregulationofh3k4mediatedgeneexpression
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