SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
Abstract SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis. Here, we show that SMYD3 modulates another hallmark of cancer, DNA repair, by stimulating transcription of genes inv...
Guardado en:
Autores principales: | Yun-Ju Chen, Cheng-Hui Tsai, Pin-Yu Wang, Shu-Chun Teng |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/8b12ae6cfb12445e9427d337286f3466 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structural and functional profiling of the human histone methyltransferase SMYD3.
por: Kenneth W Foreman, et al.
Publicado: (2011) -
ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
por: Arun Kanakkanthara, et al.
Publicado: (2019) -
SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases
por: Weijun Wu, et al.
Publicado: (2021) -
K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
por: Han-Tsang Wu, et al.
Publicado: (2016) -
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
por: Nina M. S. Gustafsson, et al.
Publicado: (2018)